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Mitochondrial ribosomes in a trypanosome
Biochemical and Biophysical Research Communications, 2003The nature, and even the existence, of trypanosome mitochondrial ribosomes has been the subject of some debate. We investigated this further in the insect trypanosome, Crithidia fasciculata. In sucrose gradients of parasite lysates, mitochondrial ribosomal RNA co-sediments at approximately 35S with nascent peptides synthesized in the presence of the ...
Ivor, Tittawella +2 more
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The trypanosome flagellar pocket
Nature Reviews Microbiology, 2009Trypanosomes are important disease agents and excellent models for the study of evolutionary cell biology. The trypanosome flagellar pocket is a small invagination of the plasma membrane where the flagellum exits the cytoplasm and participates in many cellular processes.
Mark C, Field, Mark, Carrington
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Antigenic Variation in Trypanosomes
The American Journal of Tropical Medicine and Hygiene, 1977Abstract The several species of African trypanosomes pathogenic to man and domestic livestock may evade the immune response through a process of antigenic variation. This phenomenon is the major obstacle to immunization. Variation may be recognized in the form of sequential changes in the serological characteristics of the trypanosome
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The African trypanosome genome
International Journal for Parasitology, 2000The haploid nuclear genome of the African trypanosome, Trypanosoma brucei, is about 35 Mb and varies in size among different trypanosome isolates by as much as 25%. The nuclear DNA of this diploid organism is distributed among three size classes of chromosomes: the megabase chromosomes of which there are at least 11 pairs ranging from 1 Mb to more than
N M, El-Sayed +4 more
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1999
Abstract As mentioned, the trypanosomes are closely related to the leishmaniae, and their zoologic classification follows the same lines (see Chapter 4; Corliss, 1994). Trypanosomes are known in general as the blood flagellates, and under natural conditions they occur in humans and many other species of animals.
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Abstract As mentioned, the trypanosomes are closely related to the leishmaniae, and their zoologic classification follows the same lines (see Chapter 4; Corliss, 1994). Trypanosomes are known in general as the blood flagellates, and under natural conditions they occur in humans and many other species of animals.
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Cultivation of Mammalian Trypanosomes*
The Journal of Protozoology, 1964SYNOPSIS. Cultivation of the mammalian trypanosomes can be accomplished in the following artificial environments: monophasic and diphasic blood agar, dialysate, undefined, and partially defined liquid media, semisolid media, avian embryos, and tissue cultures.
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Infecting Triatomines with Trypanosomes
2020The infection of triatomines with trypanosomes can be performed with different forms of the parasite, and the procedure is important not only for vector-parasite interaction studies but also for maintaining the infectivity of parasite strains, which guarantees more realistic biological and molecular investigations.
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Deformation of erythrocytes by trypanosomes
Experimental Cell Research, 1965The movements of Trypanosoma brucei are briefly described. The deformation of mouse erythrocytes by this organism is illustrated and the magnitude of the deforming force calculated.
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Antigenic variation in trypanosomes
Nature, 1978In its mammalian host, Trypanosoma brucei is able to change the antigenic character of its glycoprotein surface coat and so evade the host's immune response. This phenotypic change seems to occur spontaneously in 1 in 10,000 individuals but is not due to genetic mutation: host antibody is not necessary for its induction but plays a selective part in ...
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Antigens of African Trypanosomes
1985The African trypanosomes present their hosts with the best characterised antigens in parasitology — the variant surface glycoproteins, or VSGs. The structure of the genes encoding VSGs and the mechanism by which the expression of these genes is regulated have been studied intensively (reviewed in Steinert and Pays 1985). Research in this area is at the
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