Results 11 to 20 of about 14,002 (136)

α-d-Glucopyranosyl-(1→2)-[6-O-(l-tryptophanyl)-β-d-fructofuranoside]

Molbank, 2019
The Mycobacterium sp. BRS2A-AR2 is an endophyte of the mangrove plant Rhizophora racemosa G. Mey., which grows along the banks of the River Butre, in the Western Region of Ghana.
Kwaku Kyeremeh, Samuel Kwain, Gilbert Mawuli Tetevi, Anil Sazak Camas, Mustafa Camas, Aboagye Kwarteng Dofuor, Hai Deng, Marcel Jaspars   +7 more
doaj   +1 more source

Structure, Properties, and Function of Glycosomes in Trypanosoma cruzi

Frontiers in Cellular and Infection Microbiology, 2020
Glycosomes are peroxisome-related organelles that have been identified in kinetoplastids and diplonemids. The hallmark of glycosomes is their harboring of the majority of the glycolytic enzymes.
Wilfredo Quiñones, Héctor Acosta, Camila Silva Gonçalves, Maria Cristina M. Motta, Melisa Gualdrón-López, Paul A. M. Michels   +5 more
doaj   +1 more source

Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Trypanothione synthetase (TryS) produces N1,N8-bis(glutathionyl)spermidine (or trypanothione) at the expense of ATP. Trypanothione is a metabolite unique and essential for survival and drug-resistance of trypanosomatid parasites. In this study, we report
Andrea Medeiros, Diego Benítez, Ricarda S. Korn, Vinicius C. Ferreira, Exequiel Barrera, Federico Carrión, Otto Pritsch, Sergio Pantano, Conrad Kunick, Camila I. de Oliveira, Oliver C. F. Orban, Marcelo A. Comini   +11 more
doaj   +1 more source

(E)-5-(Methoxyimino)-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

Molbank, 2021
(E)-5-(Methoxyimino)-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one was prepared by a condensation reaction from 3,4-dihydro-1H-benzo[b]azepin-2,5-dione and O-methylhydroxylamine.
Irina Ihnatenko, Peter G. Jones, Conrad Kunick   +2 more
doaj   +1 more source

The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes

eLife, 2016
The role of mammalian skin in harbouring and transmitting arthropod-borne protozoan parasites has been overlooked for decades as these pathogens have been regarded primarily as blood-dwelling organisms.
Paul Capewell, Christelle Cren-Travaillé, Francesco Marchesi, Pamela Johnston, Caroline Clucas, Robert A Benson, Taylor-Anne Gorman, Estefania Calvo-Alvarez, Aline Crouzols, Grégory Jouvion, Vincent Jamonneau, William Weir, M Lynn Stevenson, Kerry O'Neill, Anneli Cooper, Nono-raymond Kuispond Swar, Bruno Bucheton, Dieudonné Mumba Ngoyi, Paul Garside, Brice Rotureau, Annette MacLeod   +20 more
doaj   +1 more source

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Molecules, 2016
Glucose-6-phosphate dehydrogenase (G6PDH) plays a housekeeping role in cell metabolism by generating reducing power (NADPH) and fueling the production of nucleotide precursors (ribose-5-phosphate).
Cecilia Ortiz, Francesca Moraca, Andrea Medeiros, Maurizio Botta, Niall Hamilton, Marcelo A. Comini   +5 more
doaj   +1 more source

Shared species of crocodilian trypanosomes carried by tabanid flies in Africa and South America, including the description of a new species from caimans, Trypanosoma kaiowa n. sp.

Parasites & Vectors, 2019
Background The genus Trypanosoma Gruby, 1843 is constituted by terrestrial and aquatic phylogenetic lineages both harboring understudied trypanosomes from reptiles including an increasing diversity of crocodilian trypanosomes.
Bruno R. Fermino, Fernando Paiva, Laerte B. Viola, Carla M. F. Rodrigues, Herakles A. Garcia, Marta Campaner, Carmen S. A. Takata, Desie Sheferaw, John J. Kisakye, Agapitus Kato, Carlos A. G. S. Jared, Marta M. G. Teixeira, Erney P. Camargo   +12 more
doaj   +1 more source

Tissue tropism in parasitic diseases [PDF]

Open Biology, 2019
Parasitic diseases, such as sleeping sickness, Chagas disease and malaria, remain a major cause of morbidity and mortality worldwide, but particularly in tropical, developing countries.
Sara Silva Pereira, Sandra Trindade, Mariana De Niz, Luisa M. Figueiredo   +3 more
doaj   +1 more source

Molecular Detection of Trypanosoma spp. in Questing and Feeding Ticks (Ixodidae) Collected from an Endemic Region of South-West Australia

Pathogens, 2021
A growing number of indigenous trypanosomes have been reported to naturally infect a variety of Australian wildlife with some species of Trypanosoma implicated in the population decline of critically endangered marsupials.
Anna-Sheree Krige, R. C. Andrew Thompson, Anke Seidlitz, Sarah Keatley, Julia Wayne, Peta L. Clode   +5 more
doaj   +1 more source

Expanding the applications of a bioluminescent mouse infection model of acute African trypanosomiasis

Frontiers in Chemical Biology
IntroductionIn vivo imaging technology based on bioluminescence has contributed to the study of different pathophysiological conditions involving inherited or transmissible diseases.
Diego Benítez, Cecilia Ortíz, Estefania Dibello, Estefania Dibello, Marcelo A. Comini   +4 more
doaj   +1 more source