Results 21 to 30 of about 54,903 (309)

The Dual Role of the 16mer Motif Within the 3' Untranslated Region of the Variant Surface Glycoprotein of Trypanosoma brucei. [PDF]

Mol Microbiol
A fully conserved 16mer motif is required in the silent VSG to trigger efficient silencing of the expression site (ES)‐resident VSG and a successful exchange of the VSG coat. ABSTRACT The variant surface glycoprotein (VSG) of African trypanosomes is essential for the survival of bloodstream form parasites.
Bakari-Soale M, Batram C, Zimmermann H, Jones NG, Engstler M.   +4 more
europepmc   +2 more sources

Extravascular Dermal Trypanosomes in Suspected and Confirmed Cases of gambiense Human African Trypanosomiasis

Clinical Infectious Diseases, 2020
Background The diagnosis of gambiense human African trypanosomiasis (gHAT) typically involves 2 steps: a serological screen, followed by the detection of living trypanosome parasites in the blood or lymph node aspirate.
M. Camara, Alseny M’mah Soumah, H. Ilboudo, C. Travaillé, C. Clucas, Anneli Cooper, Nono-Raymond Kuispond Swar, Oumou M. Camara, I. Sadissou, Estefanía Calvo Alvarez, A. Crouzols, J. Bart, V. Jamonneau, M. Camara, A. MacLeod, B. Bucheton, B. Rotureau   +16 more
semanticscholar   +1 more source

Detection of Trypanosoma Infection in Dromedary Camels by Using Different Diagnostic Techniques in Northern Oman

Animals, 2022
Camel trypanosomoses is considered a devastating disease with severe health consequences that can be caused by different hemoprotozoan parasites. Camel samples (388) from the five regions in Northern Oman were assessed using a thin blood film.
Amal Al-Kharusi, Elshafie Ibrahim Elshafie, Senan Baqir, Asim Faraz, Aliya Al-Ansari, Pamela Burger, Osman Mahgoub, Kaadhia Al-Kharousi, Halima Al-Duhli, Mohammed Al-Sinani, Raqiya Al-Hatali, Derek Roberts   +11 more
doaj   +1 more source

Mosquito Trypanosomes [PDF]

Journal of Hygiene, 1906
In a previous paper on Bird Trypanosomes it was pointed out that these organisms grew readily in the test-tube on blood agar and that the resulting forms resembled the flagellates which Schaudinn found in the gut of mosquitoes which had fed on owls infected with Halteridium and with H. Ziemanni.
F G, Novy, W J, Macneal, H N, Torrey
openaire   +2 more sources

Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Trypanothione synthetase (TryS) produces N1,N8-bis(glutathionyl)spermidine (or trypanothione) at the expense of ATP. Trypanothione is a metabolite unique and essential for survival and drug-resistance of trypanosomatid parasites. In this study, we report
Andrea Medeiros, Diego Benítez, Ricarda S. Korn, Vinicius C. Ferreira, Exequiel Barrera, Federico Carrión, Otto Pritsch, Sergio Pantano, Conrad Kunick, Camila I. de Oliveira, Oliver C. F. Orban, Marcelo A. Comini   +11 more
doaj   +1 more source

Assessing the Tsetse Fly Microbiome Composition and the Potential Association of Some Bacteria Taxa with Trypanosome Establishment

Microorganisms, 2022
The tsetse flies, biological vectors of African trypanosomes, harbour a variety of bacteria involved in their vector competence that may help in developing novel vector control tools.
Calmes Ursain Bouaka Tsakeng, Tito Tresor Melachio Tanekou, Steve Feudjio Soffack, Inaki Tirados, Cedrique Noutchih, Flobert Njiokou, Jude Daiga Bigoga, Charles Sinclair Wondji   +7 more
doaj   +1 more source

Trypanosome Glycosylphosphatidylinositol Biosynthesis [PDF]

The Korean Journal of Parasitology, 2009
Trypanosoma brucei, a protozoan parasite, causes sleeping sickness in humans and Nagana disease in domestic animals in central Africa. The trypanosome surface is extensively covered by glycosylphosphatidylinositol (GPI)-anchored proteins known as variant surface glycoproteins and procyclins.
Yeonchul, Hong, Taroh, Kinoshita
openaire   +2 more sources

To the Skin and Beyond: The Immune Response to African Trypanosomes as They Enter and Exit the Vertebrate Host

Frontiers in Immunology, 2020
African trypanosomes are single-celled extracellular protozoan parasites transmitted by tsetse fly vectors across sub-Saharan Africa, causing serious disease in both humans and animals.
Omar A Alfituri, Juan F. Quintana, A. MacLeod, P. Garside, R. Benson, J. Brewer, N. Mabbott, L. Morrison, P. Capewell   +8 more
semanticscholar   +1 more source

Prevalence and Association of Trypanosomes and Sodalis glossinidius in Tsetse Flies from the Kafue National Park in Zambia

Tropical Medicine and Infectious Disease, 2023
Tsetse flies are obligate hematophagous vectors of animal and human African trypanosomosis. They cyclically transmit pathogenic Trypanosoma species. The endosymbiont Sodalis glossinidius is suggested to play a role in facilitating the susceptibility of ...
Simegnew Adugna Kallu, Joseph Ndebe, Yongjin Qiu, Ryo Nakao, Martin C. Simuunza   +4 more
doaj   +1 more source

The long and winding road of reverse genetics in Trypanosoma cruzi

Microbial Cell, 2021
Trypanosomes are early divergent protists with distinctive features among eukaryotic cells. Together with Trypanosoma brucei and Leishmania spp., Trypanosoma cruzi has been one of the most studied members of the group.
Miguel A. Chiurillo, Noelia Lander
doaj   +1 more source