Results 21 to 30 of about 39,396 (251)

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Molecules, 2016
Glucose-6-phosphate dehydrogenase (G6PDH) plays a housekeeping role in cell metabolism by generating reducing power (NADPH) and fueling the production of nucleotide precursors (ribose-5-phosphate).
Cecilia Ortiz, Francesca Moraca, Andrea Medeiros, Maurizio Botta, Niall Hamilton, Marcelo A. Comini   +5 more
doaj   +1 more source

Activation of endocytosis as an adaptation to the mammalian host by trypanosomes [PDF]

, 2007
Immune evasion in African trypanosomes is principally mediated by antigenic variation, but rapid internalization of surface-bound immune factors may contribute to survival.
Field, Mark C, Gibson, Wendy, Matthews, Keith, Natesan, Senthil Kumar A, Peacock, Lori   +4 more
core   +2 more sources

The CAF1-NOT complex of trypanosomes [PDF]

Frontiers in Genetics, 2014
In African trypanosomes, there is no control of transcription initiation by RNA polymerase II at the level of individual protein-coding genes. Transcription is polycistronic, and individual mRNAs are excised by trans-splicing and polyadenylation. As a consequence, trypanosomes are uniquely reliant on post-transcriptional mechanisms for control of gene ...
Esteban Erben, Christine Clayton, Chaitali Chakraborty   +2 more
openaire   +4 more sources

The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes

eLife, 2016
The role of mammalian skin in harbouring and transmitting arthropod-borne protozoan parasites has been overlooked for decades as these pathogens have been regarded primarily as blood-dwelling organisms.
Paul Capewell, Christelle Cren-Travaillé, Francesco Marchesi, Pamela Johnston, Caroline Clucas, Robert A Benson, Taylor-Anne Gorman, Estefania Calvo-Alvarez, Aline Crouzols, Grégory Jouvion, Vincent Jamonneau, William Weir, M Lynn Stevenson, Kerry O'Neill, Anneli Cooper, Nono-raymond Kuispond Swar, Bruno Bucheton, Dieudonné Mumba Ngoyi, Paul Garside, Brice Rotureau, Annette MacLeod   +20 more
doaj   +1 more source

Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Trypanothione synthetase (TryS) produces N1,N8-bis(glutathionyl)spermidine (or trypanothione) at the expense of ATP. Trypanothione is a metabolite unique and essential for survival and drug-resistance of trypanosomatid parasites. In this study, we report
Andrea Medeiros, Diego Benítez, Ricarda S. Korn, Vinicius C. Ferreira, Exequiel Barrera, Federico Carrión, Otto Pritsch, Sergio Pantano, Conrad Kunick, Camila I. de Oliveira, Oliver C. F. Orban, Marcelo A. Comini   +11 more
doaj   +1 more source

Metabolite-dependent regulation of gene expression in trypanosoma brucei [PDF]

, 2013
Mechanisms regulating gene expression in trypanosomatid protozoa differ significantly from those in other eukaryotes. Transcription of the genome appears to be more or less constitutive with the polyadenylation and trans-splicing of large polycistronic ...
Archer, Batey, Besteiro, Birkholtz, Breaker, Carter, Clayton, Coustou, De Gaudenzi, Ebikeme, Fairlamb, Hendriks, Jacob, Jensen, Kabani, Lamour, Mangold, Martinez-Calvillo, Nguyen, Perez-Leal, Persson, Phillips, Stuart, Veitch, Vincent, Ward, Willert, Willert, Willert, Wirtz, Wurst, Wurst, Xiao, Xiao, Zhang   +34 more
core   +1 more source

α-d-Glucopyranosyl-(1→2)-[6-O-(l-tryptophanyl)-β-d-fructofuranoside]

Molbank, 2019
The Mycobacterium sp. BRS2A-AR2 is an endophyte of the mangrove plant Rhizophora racemosa G. Mey., which grows along the banks of the River Butre, in the Western Region of Ghana.
Kwaku Kyeremeh, Samuel Kwain, Gilbert Mawuli Tetevi, Anil Sazak Camas, Mustafa Camas, Aboagye Kwarteng Dofuor, Hai Deng, Marcel Jaspars   +7 more
doaj   +1 more source

Influence of the Draining Lymph Nodes and Organized Lymphoid Tissue Microarchitecture on Susceptibility to Intradermal Trypanosoma brucei Infection

Frontiers in Immunology, 2020
Infection of the mammalian host with African trypanosomes begins when the tsetse fly vector injects the parasites into the skin dermis during blood feeding.
Omar A. Alfituri, Barry M. Bradford, Edith Paxton, Liam J. Morrison, Neil A. Mabbott   +4 more
doaj   +1 more source

Trypanosomes at the Gates [PDF]

Science, 2005
L ike many colleagues, I sometimes thought I'd never see the day when three small parasites would be so celebrated. After all, why should people outside of the small cohort of dedicated scientists and sponsors pay any attention to these “Tritryps”— Trypanosoma brucei, Trypanosoma cruzi , and Leishmania major —whose genomes appear in this issue of ...
openaire   +3 more sources

Infections With Extracellular Trypanosomes Require Control by Efficient Innate Immune Mechanisms and Can Result in the Destruction of the Mammalian Humoral Immune System

Frontiers in Immunology, 2020
Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game animals around the world. Through co-evolution with the mammalian immune system, trypanosomes have developed defense mechanisms that allow them to thrive in blood,
Stefan Magez, Stefan Magez, Stefan Magez, Joar Esteban Pinto Torres, Emmanuel Obishakin, Emmanuel Obishakin, Magdalena Radwanska, Magdalena Radwanska   +7 more
doaj   +1 more source