Results 21 to 30 of about 14,002 (136)

Blood and intestinal parasites of squirrels (Rodentia: Sciuridae) in Amazonian Brazil

Memorias do Instituto Oswaldo Cruz, 2004
We report the result of an examination for blood and intestinal protozoa in 12 specimens of the red squirrel Sciurus spadiceus (Rodentia: Sciuridae) from Birroque, municipality of Plácido de Castro, state of Acre, Brazil.
Ralph Lainson, Maria do Carmo de Oliveira Brígido, Fernando Tobias Silveira   +2 more
doaj   +1 more source

Development of bioluminescent reporter Trypanosoma cruzi and bioassay for compound screening

Frontiers in Chemical Biology
Trypanosoma cruzi is the etiologic agent of Chagas’ disease, a debilitating and mortal zoonotic illness that threatens the lives of several millions of people in the American continent. The acute phase is underdiagnosed and there is no curative treatment
Cristina Quiroga, Marcelo Incerti, Diego Benitez, Eduardo Manta, Andrea Medeiros, Andrea Medeiros, Marcelo A. Comini   +6 more
doaj   +1 more source

Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei

Journal of Lipid Research, 2007
Trypanosoma brucei (TB) cultured in rat blood, bovine serum, or lipid-depleted serum generated distinct differences in cholesterol availability. Whereas cell proliferation of the parasite was relatively unaffected by cholesterol availability, the ratios ...
Wenxu Zhou, George A.M. Cross, W. David Nes   +2 more
doaj   +1 more source

Influence of the Draining Lymph Nodes and Organized Lymphoid Tissue Microarchitecture on Susceptibility to Intradermal Trypanosoma brucei Infection

Frontiers in Immunology, 2020
Infection of the mammalian host with African trypanosomes begins when the tsetse fly vector injects the parasites into the skin dermis during blood feeding.
Omar A. Alfituri, Barry M. Bradford, Edith Paxton, Liam J. Morrison, Neil A. Mabbott   +4 more
doaj   +1 more source

The Lipid Raft Proteome of African Trypanosomes Contains Many Flagellar Proteins

Pathogens, 2017
Lipid rafts are liquid-ordered membrane microdomains that form by preferential association of 3-β-hydroxysterols, sphingolipids and raft-associated proteins often having acyl modifications.
Aabha I. Sharma, Cheryl L. Olson, David M. Engman   +2 more
doaj   +1 more source

Infections With Extracellular Trypanosomes Require Control by Efficient Innate Immune Mechanisms and Can Result in the Destruction of the Mammalian Humoral Immune System

Frontiers in Immunology, 2020
Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game animals around the world. Through co-evolution with the mammalian immune system, trypanosomes have developed defense mechanisms that allow them to thrive in blood,
Stefan Magez, Stefan Magez, Stefan Magez, Joar Esteban Pinto Torres, Emmanuel Obishakin, Emmanuel Obishakin, Magdalena Radwanska, Magdalena Radwanska   +7 more
doaj   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome

The FEBS Journal, EarlyView.
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
Corinne von Känel, Salome Aeschlimann, Michaela Husová, Silke Oeljeklaus, Philip Stettler, Achim Schnaufer, Bettina Warscheid, Alena Zíková, André Schneider   +8 more
wiley   +1 more source

A multigene family encoding surface glycoproteins in Trypanosoma congolense

Microbial Cell, 2017
Trypanosoma congolense, the causative agent of the most important livestock disease in Africa, expresses specific surface proteins involved in its parasitic lifestyle. Unfortunately, the complete repertoire of such molecules is far from being deciphered.
Magali Thonnus, Amandine Guéri, Loïc Rivière   +2 more
doaj   +1 more source

An updated checklist of Culicoides Latreille, 1809 biting midges from the highlands of eastern Democratic Republic of the Congo Une liste mise à jour des moucherons piqueurs de Culicoides Latreille, 1809 des hautes terres de l'est de la République démocratique du Congo

Medical and Veterinary Entomology, EarlyView.
The highlands of eastern Democratic Republic of the Congo (DRC) are home to critically endangered eastern gorillas (Gorilla beringei). Climate change could increase the abundance and distribution of Culicoides‐borne diseases. We utilized morphological and molecular techniques to identify Culicoides spp.
Alisa Kubala, Kristin Warren, Rudolf Meiswinkel, Michael Cranfield, Ian Robertson, Lian Yeap, Rebecca Vaughan‐Higgins, Radar Nishuli, Eddy Kambale Syaluha, Jean‐Paul Kabemba Lukusa, Martin Kabuyaya Balyananzi, Yvonne‐Marie Linton   +11 more
wiley   +1 more source