Results 31 to 40 of about 14,002 (136)

Trypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and Macrophages

Frontiers in Immunology, 2019
African trypanosomes, such as Trypanosoma brucei (T. brucei), are protozoan parasites of the mammalian vasculature and central nervous system that are best known for causing fatal human sleeping sickness.
Nicole K. Campbell, David G. Williams, Hannah K. Fitzgerald, Paul J. Barry, Clare C. Cunningham, Derek P. Nolan, Aisling Dunne, Aisling Dunne   +7 more
doaj   +1 more source

Comparative evaluation of the attractiveness of new polyethylene screens versus West African tiny target for the control of tsetse flies

Medical and Veterinary Entomology, EarlyView.
The material has no significant difference in captures (non‐shiny cotton‐polyester screens vs. the shiny polyethylene screens), but the vertical screen attracted significantly more G. tachinoides for each type of material. Full white horizontal screen was significantly lower than the reference WATT.
Ernest Wendemanegde Salou, Geoffrey Gimonneau, Wilfrid Yoni, Issiaka Barry, Viral Shah, Marc Desquesnes   +5 more
wiley   +1 more source

Glycosomal Phosphoenolpyruvate Carboxykinase CRISPR/Cas9‐Deletion and Its Role in Trypanosoma cruzi Metacyclogenesis and Infectivity in Mammalian Host

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Effects of PEPCK deficiency in Trypanosoma cruzi bioenergetics and life stages. ABSTRACT Trypanosoma cruzi, the causative agent of Chagas disease, possesses glycosomes—unique organelles that house key metabolic enzymes, several of which are promising therapeutic targets.
Carolina S. D. Vieira, Wei Wang, Fernando Sanchez‐Valdez, Jihyun Lim, Brooke E. White, Camilla G. S. Souza, Rick L. Tarleton, Marcia C. Paes, Natalia P. A. Nogueira   +8 more
wiley   +1 more source

Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

International Journal for Parasitology: Drugs and Drug Resistance
Earlier evidences showed that diglycosyl diselenides are active against the infective stage of African trypanosomes (top hits IC50 0.5 and 1.5 μM) but poorly selective (selectivity index 38-folds vs. murine and human macrohages).
Estefanía Dibello, Natalia Oddone, Jaime Franco, Tünde-Zita Illyés, Andrea Medeiros, Attila Kiss, Fanni Hőgye, Katalin E. Kövér, László Szilágyi, Marcelo A. Comini   +9 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, Volume 600, Issue 5, Page 591-611, March 2026.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The Spliced Leader RNA Silencing (SLS) Pathway in Trypanosoma brucei Is Induced by Perturbations of Endoplasmic Reticulum, Golgi Complex, or Mitochondrial Protein Factors: Functional Analysis of SLS-Inducing Kinase PK3

mBio, 2021
In the parasite Trypanosoma brucei, the causative agent of human African sleeping sickness, all mRNAs are trans-spliced to generate a common 5′ exon derived from the spliced leader (SL) RNA.
Uthman Okalang, Bar Mualem Bar-Ner, K. Shanmugha Rajan, Nehemya Friedman, Saurav Aryal, Katarina Egarmina, Ronen Hope, Netaly Khazanov, Hanoch Senderowitz, Assaf Alon, Deborah Fass, Shulamit Michaeli   +11 more
doaj   +1 more source

Stunning Intricacies of RNA Editing Complexes RECC, RESC, and REH2C: Functional Organization, Developmental Regulation, and Evolutionary History in Kinetoplastid Protists

WIREs RNA, Volume 17, Issue 2, March/April 2026.
U‐indel RNA editing targets mRNA:gRNA duplexes through three key complexes that collectively govern assembly, specificity, catalysis, and developmental regulation. Modern tools, including artificial intelligence, analyze the organization, dynamics, and evolution of the remarkable holo‐editosome, opening new avenues in RNA biology and therapy.
Suzanne M. McDermott, Julius Lukeš, Laurie K. Read, Reza Salavati, Achim Schnaufer, Sara L. Zimmer, Jason Carnes, Alasdair Ivens, Naghmeh Poorinmohammad, Nicholas J. Savill, Dave Speijer, Ken Stuart, Kristína Záhonová, Poorya Mirzavand Borujeni, Zihao Chen, Cody Goode, Sunil Kumar Sharma, Lars O’Hara, Jorge Cruz‐Reyes   +18 more
wiley   +1 more source

The haemoculture of Trypanosoma minasense chagas, 1908

Memorias do Instituto Oswaldo Cruz, 1996
Trypanosoma minasense was isolated for the first time in blood axenic culture from a naturally infected marmoset, Callithrix penicillata, from Brazil.
Mariangela Ziccardi, Ricardo Lourenço-de-Oliveira, Ricardo Nogueira   +2 more
doaj   +1 more source

Molecular Detection and Characterization of Trypanosomes Infecting Traditionally Managed Cattle in the Tropic Warm Sub-Humid Zone of Nigeria

Folia Veterinaria, 2022
Traditionally managed cattle constitutes the main source of animal protein to humans in Nigeria. However, seasonal migration in search of pasture exposes them to several vector-borne infections such as the African Animal Trypanosomosis (AAT), which ...
Kamani J., Yakubu R. A., Nnabuife H. E., Msheliza E. G., Bwala F. H., Weka P. R.   +5 more
doaj   +1 more source

Widespread Detection of Amphibian Pathogens in Frog‐Biting Midges (Corethrellidae): Implications for Xenosurveillance

Biotropica, Volume 58, Issue 2, March 2026.
Amphibian populations worldwide face threats from emerging infectious diseases. We screened frog‐biting midges (Corethrella spp.) from Central and South America for Batrachochytrium dendrobatidis, Ranaviruses, and Trypanosoma spp. using qPCR. All three pathogens were detected, indicating that Corethrella may act as vectors and represent promising tools
Jonas Virgo, Maximilian Sigl, Thomas Eltz, Maximilian Schweinsberg   +3 more
wiley   +1 more source