Results 51 to 60 of about 54,903 (309)

A single test approach for accurate and sensitive detection and taxonomic characterization of Trypanosomes by comprehensive analysis of internal transcribed spacer 1 amplicons

PLoS Neglected Tropical Diseases, 2019
To improve our knowledge on the epidemiological status of African trypanosomiasis, better tools are required to monitor Trypanosome genotypes circulating in both mammalian hosts and tsetse fly vectors.
A. Gaithuma, J. Yamagishi, A. Martinelli, K. Hayashida, Naoko Kawai, Megasari Marsela, C. Sugimoto   +6 more
semanticscholar   +1 more source

Tissue tropism in parasitic diseases [PDF]

Open Biology, 2019
Parasitic diseases, such as sleeping sickness, Chagas disease and malaria, remain a major cause of morbidity and mortality worldwide, but particularly in tropical, developing countries.
Sara Silva Pereira, Sandra Trindade, Mariana De Niz, Luisa M. Figueiredo   +3 more
doaj   +1 more source

Expanding the applications of a bioluminescent mouse infection model of acute African trypanosomiasis

Frontiers in Chemical Biology
IntroductionIn vivo imaging technology based on bioluminescence has contributed to the study of different pathophysiological conditions involving inherited or transmissible diseases.
Diego Benítez, Cecilia Ortíz, Estefania Dibello, Estefania Dibello, Marcelo A. Comini   +4 more
doaj   +1 more source

Blood and intestinal parasites of squirrels (Rodentia: Sciuridae) in Amazonian Brazil

Memorias do Instituto Oswaldo Cruz, 2004
We report the result of an examination for blood and intestinal protozoa in 12 specimens of the red squirrel Sciurus spadiceus (Rodentia: Sciuridae) from Birroque, municipality of Plácido de Castro, state of Acre, Brazil.
Ralph Lainson, Maria do Carmo de Oliveira Brígido, Fernando Tobias Silveira   +2 more
doaj   +1 more source

Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death

eLife, 2018
Tryparedoxin peroxidases, distant relatives of glutathione peroxidase 4 in higher eukaryotes, are responsible for the detoxification of lipid-derived hydroperoxides in African trypanosomes.
Marta Bogacz, R. Krauth-Siegel
semanticscholar   +1 more source

Molecular Detection of Trypanosoma spp. in Questing and Feeding Ticks (Ixodidae) Collected from an Endemic Region of South-West Australia

Pathogens, 2021
A growing number of indigenous trypanosomes have been reported to naturally infect a variety of Australian wildlife with some species of Trypanosoma implicated in the population decline of critically endangered marsupials.
Anna-Sheree Krige, R. C. Andrew Thompson, Anke Seidlitz, Sarah Keatley, Julia Wayne, Peta L. Clode   +5 more
doaj   +1 more source

Development of bioluminescent reporter Trypanosoma cruzi and bioassay for compound screening

Frontiers in Chemical Biology
Trypanosoma cruzi is the etiologic agent of Chagas’ disease, a debilitating and mortal zoonotic illness that threatens the lives of several millions of people in the American continent. The acute phase is underdiagnosed and there is no curative treatment
Cristina Quiroga, Marcelo Incerti, Diego Benitez, Eduardo Manta, Andrea Medeiros, Andrea Medeiros, Marcelo A. Comini   +6 more
doaj   +1 more source

Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei

Journal of Lipid Research, 2007
Trypanosoma brucei (TB) cultured in rat blood, bovine serum, or lipid-depleted serum generated distinct differences in cholesterol availability. Whereas cell proliferation of the parasite was relatively unaffected by cholesterol availability, the ratios ...
Wenxu Zhou, George A.M. Cross, W. David Nes   +2 more
doaj   +1 more source

Simplifying microfluidic separation devices towards field-detection of blood parasites [PDF]

, 2016
With our sights set on a simple and inexpensive diagnostics device based on extraction and enrichment of parasites from human blood, we present a device design that relies on a combination of multiple different deterministic lateral displacement arrays ...
Barrett, M.P., Beech, J.P., Holm, S.H., Tegenfeldt, J.O.   +3 more
core   +3 more sources

Codon choice directs constitutive mRNA levels in trypanosomes

eLife, 2018
Selective transcription of individual protein coding genes does not occur in trypanosomes and the cellular copy number of each mRNA must be determined post-transcriptionally.
Janaina de Freitas Nascimento, S. Kelly, J. Sunter, M. Carrington   +3 more
semanticscholar   +1 more source