Results 61 to 70 of about 39,396 (251)

Bioactivity profiles of progressively ring‐fluorinated cyclohexyl motifs in the WKYMVm peptide as formylpeptide FPR2 agonists and in keto‐piperazines as anti‐trypanosome agents.

ChemBioChem, Accepted Article.
A series of all‐cis ring fluorinated cyclohexylalanines with progressively increasing levels of vicinal fluorines, as well as 4‐fluorophenylalanine and pentafluoroarylphenylalanine were introduced into the WKYMVm peptide in place of its tyrosine residue, for assays against the G‐protein coupled formylpeptide receptor, FPR2.
David O'Hagan, Mengfan He, Christina M Thomson, Dawn Thompson, Vytautus Kuodis, Terence K. Smith, Sergio Dall'Angelo   +6 more
wiley   +1 more source

The haemoculture of Trypanosoma minasense chagas, 1908

Memorias do Instituto Oswaldo Cruz, 1996
Trypanosoma minasense was isolated for the first time in blood axenic culture from a naturally infected marmoset, Callithrix penicillata, from Brazil.
Mariangela Ziccardi, Ricardo Lourenço-de-Oliveira, Ricardo Nogueira   +2 more
doaj   +1 more source

Molecular epidemiology of African sleeping sickness [PDF]

, 2009
Human sleeping sickness in Africa, caused by Trypanosoma brucei spp. raises a number of questions. Despite the widespread distribution of the tsetse vectors and animal trypanosomiasis, human disease is only found in discrete foci which periodically give ...
A. TAIT, G. HIDE, Gibson, Hide, Mehlitz, Morrison   +5 more
core   +2 more sources

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Immune priming of honey bees protects against a major microsporidian pathogen

Pest Management Science, EarlyView.
We immune‐primed honey bees at two developmental stages in the laboratory and the field with heat‐killed Nosema ceranae spores. When subsequently fed live spores, immune‐primed adults had lower infection levels. Abstract BACKGROUND Honey bees face significant threats from pathogens like Nosema ceranae, a microsporidian parasite that contributes to ...
James C. Nieh, Matthew Endler, Andrey Rubanov, Alexander Neskovic, Xianbing Xie, Honghong Li, Zachary Y. Huang   +6 more
wiley   +1 more source

Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity [PDF]

, 2009
Antigenic variation is an immune evasion strategy that has evolved in viral, bacterial and protistan pathogens. In the African trypanosome this involves stochastic switches in the composition of a variant surface glycoprotein (VSG) coat, using a massive ...
Marcello, Lucio, McCulloch, Richard, Morrison, Liam J.   +2 more
core   +1 more source

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis

Insect Science, EarlyView.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +1 more source

The Trypanosoma brucei AIR9-like protein is cytoskeleton-associated and is required for nucleus positioning and accurate cleavage furrow placement [PDF]

, 2012
AIR9 is a cytoskeleton-associated protein in Arabidopsis thaliana with roles in cytokinesis and cross wall maturation, and reported homologues in land plants and excavate protists, including trypanosomatids.
Almeida Costa, Cristina, Gibson, Wendy, Hammarton, Tansy, May, Sophie, Peacock, Lori, Robinson, Derrick, Robinson, Derrick R, Tetley, Laurence   +7 more
core   +2 more sources

tRNA Biology in Trypanosomes

CHIMIA, 2019
Besides their medical importance, the parasitic protozoan Trypanosoma brucei and its relatives are experimentally highly accessible model systems for many cell biological processes. Trypanosomes are phylogenetically essentially unrelated to the popular model eukaryotes, such as yeast and animals, and thus show several unique features, many of
Shikha, Shikha, Brogli, Rebecca, Schneider, André, Polacek, Norbert   +3 more
openaire   +5 more sources

Effect of Spiroplasma infection on the mating behavior of Glossina fuscipes fuscipes

Insect Science, EarlyView.
Abstract Tsetse flies are insects of significant public health and zoonotic importance as they are the main vectors of African trypanosomes. To date, an effective vaccine is unavailable and efforts to limit the spread of the disease primarily rely on controlling the tsetse populations.
Giulia Fiorenza, Riccardo Piccinno, Daniel J. Bruzzese, Francesca Scolari, Gloria Milanesi, Claudio Casali, Ludvik M. Gomulski, Francesco Lescai, Federico Forneris, Giuliano Gasperi, Kiswend‐sida M. Dera, Chantel de Beer, Adly M.M. Abd‐Alla, Serap Aksoy, Anna R. Malacrida   +14 more
wiley   +1 more source