Results 21 to 30 of about 5,575 (182)

A literature review of economic evaluations for a neglected tropical disease : human African trypanosomiasis ("sleeping sickness") [PDF]

, 2015
Human African trypanosomiasis (HAT) is a disease caused by infection with the parasite Trypanosoma brucei gambiense or T. b. rhodesiense. It is transmitted to humans via the tsetse fly.
Sutherland, C. S., Joshua Yukich, Tediosi, F., C. Simone Sutherland (689448), C Simone Sutherland, Ron Goeree (201687), Fabrizio Tediosi (247282), TEDIOSI, FABRIZIO, Ron Goeree, Goerre, R., Yukich, Joshua, Sutherland, C. Simone, Yukich, J., C. Simone Sutherl, Fabrizio Tediosi, Joshua Yukich (44606), Goeree, Ron   +16 more
core   +1 more source

APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis

eLife, 2017
Reduced susceptibility to infectious disease can increase the frequency of otherwise deleterious alleles. In populations of African ancestry, two apolipoprotein-L1 (APOL1) variants with a recessive kidney disease risk, named G1 and G2, occur at high ...
Anneli Cooper, Hamidou Ilboudo, V Pius Alibu, Sophie Ravel, John Enyaru, William Weir, Harry Noyes, Paul Capewell, Mamadou Camara, Jacqueline Milet, Vincent Jamonneau, Oumou Camara, Enock Matovu, Bruno Bucheton, Annette MacLeod   +14 more
doaj   +1 more source

Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis [PDF]

, 2011
Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites <i>Trypanosoma brucei</i> (<i>T.b.</i>) <i>gambiense</i> or <i>T.b.rhodesiense</i> and is ...
Jones, A., Michael P. Barrett, Peter G E Kennedy, Bradley Barbara, Bradley, Barbara, Barrett, M. P., McCabe Christopher, Peter G. E. Kennedy, Bradley, B., Rodgers, Jean, Gettinby, George, Gettinby George, Kennedy Peter G. E., McCabe, Chris, Amy Jones, Kennedy, Peter G. E., Barrett, Michael P., Michael P Barrett, Kennedy, Peter G.E., George Gettinby, Gibaud, Stephane, Barbara Bradley, McCabe, C., Mccabe, Christopher, Jean Rodgers, Kennedy, P. G. E., Gibaud, S., Stéphane Gibaud, Rodgers, J., Rodgers Jean, Jones Amy, Jones, Amy, Christopher McCabe, Barrett Michael P., Gibaud Stéphane, Gettinby, G.   +35 more
core   +1 more source

Breeding of African sheep reared under low-input/output smallholder production systems for trypanotolerance [PDF]

Veterinary World, 2022
Trypanosomiasis is a disease caused by unicellular protozoan parasites. Small ruminants succumb to trypanosomiasis in areas of high tsetse fly challenge, resulting in serious economic loss often to farmers in low-input smallholder systems.
Dikeledi P. Malatji
doaj   +1 more source

Prevalence and under-detection of gambiense human African trypanosomiasis during mass screening sessions in Uganda and Sudan [PDF]

, 2012
BACKGROUND: Active case detection through mass community screening is a major control strategy against human African trypanosomiasis (HAT, sleeping sickness) caused by T. brucei gambiense.
Haydon Daniel T, Chappuis, F., Cox, A.P., Cox Andrew P, Checchi Francesco, Haydon, D.T., Priotto Gerardo, Priotto, Gerardo, Checchi, Francesco, Chandramohan, Daniel, Priotto, G., Haydon, Daniel T, Cox, Andrew P, Checchi, F., Chandramohan, D., Chappuis, François, Chappuis François, Chandramohan Daniel   +17 more
core   +1 more source

Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis [PDF]

, 2013
There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the need for patient hospitalization, thus reducing healthcare costs of HAT.
Arlene S. Bridges (301008), Shelley Ching, Bridges, Arlene S., Raymond E Mdachi, Brun Reto, Wang Michael Zhuo, Wang, Michael Zhuo, Wolf, Kristina K., Ching, Shelley, Arlene S Bridges, Mutuku James N., Murilla, Grace A., Paine, Mary F., Boykin, David W., James N Mutuku, Richard R Tidwell, Mohamed A Ismail, John K. Thuita (148377), Liu, Qiang, Tidwell, Richard R., Hall, James E., Mary F. Paine (148396), John K Thuita, Bridges Arlene S., Ismail Mohamed A., Mdachi, Raymond E., Qiang Liu (166143), Mdachi Raymond E., David W. Boykin (148406), Reto Brun, Reto Brun (41511), Ching Shelley, Hall, James Edwin, Shelley Ching (148404), Tidwell Richard R., Chen, Yao, Mohamed A. Ismail (418629), Boykin David W., Mutuku, James N., James Edwin Hall, Qiang Liu, Grace A Murilla, Hall James Edwin, Raymond E. Mdachi (148398), Mary F Paine, Liu Qiang, Kristina K. Wolf (418627), Michael Zhuo Wang, Thutia, John K., David W Boykin, Yao Chen (149006), Grace A. Murilla (148401), Ismail, Mohamed A., Michael Zhuo Wang (418631), Murilla Grace A., Wolf Kristina K., Kristina K Wolf, James Edwin Hall (418630), Thuita John K., James N. Mutuku (418628), Brun, Reto, Yao Chen, Thuita, John K., Richard R. Tidwell (148409), Paine Mary F., Chen Yao   +65 more
core   +1 more source

Pharmacological investigations on current and new drugs for treatment of human African trypanosomiasis [PDF]

, 1999
Trypanosomiasis remains a major threat to humans in sub-Saharan Africa with 55-60 million people in 36 countries at risk of infection with T.b. gambiense or T.b. rhodesiense.
Keiser, Jennifer
core   +1 more source

Human African Trypanosomiasis Transmission, Kinshasa, Democratic Republic of Congo

Emerging Infectious Diseases, 2006
To investigate the epidemiology of human African trypanosomiasis (sleeping sickness) in Kinshasa, Democratic Republic of Congo, 2 entomologic surveys were conducted in 2005.
Gustave Simo, Philemon Mansinsa Diabakana, Victor Kande Betu Ku Mesu, Emile Zola Manzambi, Gaelle Ollivier, Tazoacha Asonganyi, Gerard Cuny, Pascal Grébaut   +7 more
doaj   +1 more source

A doença de Chagas: repercussões de uma descoberta científica brasileira em Portugal, 1909-1924

Ler História, 2022
Currently, Chagas disease, or human American trypanosomiasis, affects around 900 people in Portugal, mostly Brazilian immigrants, the main foreign population residing in the country.
Ewerton Luiz Figueiredo Moura da Silva
doaj   +1 more source

Trypanosoma brucei Tim50 Possesses PAP Activity and Plays a Critical Role in Cell Cycle Regulation and Parasite Infectivity

mBio, 2021
African trypanosomiasis is a neglected tropical disease caused by the parasitic protozoan Trypanosoma bruceiT.
Anuj Tripathi, Ujjal K. Singha, Ayorinde Cooley, Taneisha Gillyard, Evan Krystofiak, Siddharth Pratap, Jamaine Davis, Minu Chaudhuri   +7 more
doaj   +1 more source