Results 11 to 20 of about 1,367,511 (214)

The history of African trypanosomiasis [PDF]

Parasites & Vectors, 2008
The prehistory of African trypanosomiasis indicates that the disease may have been an important selective factor in the evolution of hominids. Ancient history and medieval history reveal that African trypanosomiasis affected the lives of people living in
Steverding Dietmar
doaj   +4 more sources

Human African trypanosomiasis [PDF]

The Lancet, 2010
Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies. Almost all cases are due to Trypanosoma brucei gambiense, which is indigenous to west and central Africa.
Brun, R., Blum, J., Chappuis, F., Burri, C.   +3 more
openaire   +5 more sources

African Trypanosomiasis Gambiense, Italy

Emerging Infectious Diseases, 2005
African trypanosomiasis caused by Trypanosoma brucei gambiense has not been reported in Italy. We report 2 cases diagnosed in the summer of 2004. Theses cases suggest an increased risk for expatriates working in trypanosomiasis-endemic countries.
Zeno Bisoffi, Anna Beltrame, Geraldo Monteiro, Alessandra Arzese, Stefania Marocco, Giada Rorato, Mariella Anselmi, Pierluigi Viale   +7 more
doaj   +6 more sources

Probing 5‐Nitroimidazole‐Triazole Hybrids as Potential Anti‐Kinetoplastid Agents: Synthesis and In Vitro Efficacy [PDF]

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Liandi Ferreira, Gideon D. Badenhorst, Janine Aucamp, Keisuke Suganuma, David D. N’Da   +4 more
wiley   +2 more sources

Identification of New Anti‐Trypanosoma brucei Leads: An Integrated CRK12‐Guided Virtual Screen With Experimental Validation [PDF]

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
An integrated computational‐experimental workflow enabled CRK12‐guided hit discovery against Trypanosoma brucei under limited structural and ligand data. The workflow of virtual screening and anti‐T. brucei bioassays identified 4 hit compounds, including three low‐micromolar leads (IC50 = 1.47, 0.81, and 1.33 μM). ABSTRACT Human African trypanosomiasis
Qin Li, Chenggong Fu, Jiayi Luo, Qianqian Zhang, Lingling Wang, Xiaomeng Liu, Jiayue Qiu, Xiaoqing Gong, Henry H. Y. Tong, Xiaojun Yao, Dehua Lai, Huanxiang Liu   +11 more
wiley   +2 more sources

The Pathogenesis of African Trypanosomiasis

Annual Review of Pathology: Mechanisms of Disease, 2023
African trypanosomes are bloodstream protozoan parasites that infect mammals including humans, where they cause sleeping sickness. Long-lasting infection is required to favor parasite transmission between hosts. Therefore, trypanosomes have developed strategies to continuously escape innate and adaptive responses of the immune system, while also ...
Pays, Etienne, Radwanska, Magdalena, Magez, Stefan   +2 more
openaire   +4 more sources

Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human african trypanosomiasis [PDF]

, 2011
Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites Trypanosoma brucei (T.b.) gambiense or T.b.rhodesiense and is invariably fatal if untreated.
McCabe, C., Jones, A., Kennedy, P. G. E., Gibaud, S., Barrett, M. P., Rodgers, J., Bradley, B., Gettinby, G.   +7 more
core   +5 more sources

Epidemiology of human African trypanosomiasis

Clinical Epidemiology, 2014
Jose R Franco,1 Pere P Simarro,1 Abdoulaye Diarra,2 Jean G Jannin1 1World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland; 2World Health Organization, Inter Country Support ...
Franco JR, Simarro PP, Diarra A, Jannin JG   +3 more
doaj   +1 more source

Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis. [PDF]

PLoS Neglected Tropical Diseases, 2013
Genetic-modification strategies are currently being developed to reduce the transmission of vector-borne diseases, including African trypanosomiasis. For tsetse, the vector of African trypanosomiasis, a paratransgenic strategy is being considered: this ...
Jan Medlock, Katherine E Atkins, David N Thomas, Serap Aksoy, Alison P Galvani   +4 more
doaj   +1 more source

A molecular mechanism for eflornithine resistance in African trypanosomes [PDF]

, 2010
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei.
Creek, Darren, Burchmore, Richard J S, Vincent, Isabel M, Watson, David G, Barrett, Michael P, Kamleh, Mohammed A, Woods, Debra J, Wong, Pui Ee   +7 more
core   +5 more sources