Results 21 to 30 of about 14,355 (116)

Regulator experiences of trials during Ebola epidemics in Sierra Leone, Guinea, and the Democratic Republic of the Congo

Tropical Medicine &International Health, Volume 30, Issue 6, Page 539-546, June 2025.
Abstract Introduction During the 2014–2016 Ebola epidemic in West Africa and the Ebola outbreaks between 2018 and 2020 in the Democratic Republic of Congo, vaccines and other tools for prevention and treatment had to be taken through trials in exceptional circumstances using accelerated processes.
Kambale Kasonia, Frank Baiden, Frédéric Le Marcis, Bruno Lapika, Joel Kiyulu, Henri Kimina, Freddy Bikioli, Fanny Attas, Anthony Mansaray, Rose Burns, Elysée Nouvet, Séverine Thys, Antea Paviotti, Daniela Manno, Mukeh Kenneth Fahnbulleh, Bailah Leigh, Mohamed Samai, Brian Greenwood, Shelley Lees, Patrick Mitashi Mulopo, Deborah Watson‐Jones   +20 more
wiley   +1 more source

Risk Evaluation and Mitigation Strategies for Newly Detected Mysterious Dinga Dinga Virus Infection in Africa: A Narrative Review

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aims The Dinga Dinga Virus (DDV) has emerged as a mysterious disease gripping women in Uganda, raising alarm due to its unusual and distressing “dancing” like symptoms. These symptoms, characterized by involuntary movements resembling dance, suggest possible neurological involvement, though the exact pathogen remains ...
Sabrina Sharmin, Salsabil Islam, Md. Aminul Haque, Md. Rabiul Islam   +3 more
wiley   +1 more source

Tick Species Infesting Livestock in Three Bioclimatic Areas of Senegal: Bioecology, Prevalence of Tick Infestation, Associated Categorical Factors and Crimean‐Congo Haemorrhagic Fever Virus Infection

Veterinary Medicine and Science, Volume 11, Issue 3, May 2025.
Ticks were collected between October 2020 and November 2022, from cattle, goats and sheep in the Sahelian, Sudano‐Sahelian and Sudanian zones, and tested for CCHFV infection. A total of 3632 animals were examined and 35.3% (95% CI: 33.8–36.9) found tick‐infested.
Aliou Khoule, Déthié Ngom, Mouhamet Faye, Ousseynou Sene, Aminata Badji, Elhadji Ndiaye, Gamou Fall, Ibrahima Dia, Mawlouth Diallo, Diawo Diallo   +9 more
wiley   +1 more source

Exploring Aspartate Transcarbamoylase: A Promising Broad‐Spectrum Target for Drug Development

ChemBioChem, Volume 26, Issue 7, April 1, 2025.
Pyrimidine biosynthesis is a pivotal process shared by both eukaryotes and prokaryotes. This review examines the applications and advantages of a series of inhibitors specifically designed to target aspartate transcarbamylase within the de novo biosynthetic pathway of the malarial parasite.
Siyao Chen, Queenie Mondile, XiaoChen Du, Chao Wang, Mayur Mukim, Carsten Wrenger, Alexander S. S. Dömling, Özlem Tastan Bishop, Matthew R. Groves   +8 more
wiley   +1 more source

Trypanosomiasis and the brain

Parasitology, 2009
SUMMARYNeurological involvement following trypanosome infection has been recognised for over a century. However, there are still many unanswered questions concerning the mechanisms used by the parasite to gain entry to the CNS and the pathogenesis of the resulting neuroinflammatory reaction.
openaire   +3 more sources

From fat storage to immune hubs: the emerging role of adipocytes in coordinating the immune response to infection

The FEBS Journal, Volume 292, Issue 8, Page 1868-1883, April 2025.
Traditionally, adipocytes have been viewed as energy storage units, which upregulate inflammatory factors in response to obesity. However, emerging evidence demonstrates that adipocytes are highly responsive to systemic infection, and upregulate cytokines and antimicrobial compounds in response.
Matthew C. Sinton, Shingo Kajimura
wiley   +1 more source

Production of Protease Inhibitor With Penicillium sp. — Optimization of the Medium for Growth in Pellet Form and Cytotoxicity Testing

Engineering in Life Sciences, Volume 25, Issue 3, March 2025.
ABSTRACT Penicillium sp. (IBWF 040‐09) produces a protease inhibitor that can potentially be used against the main protease of human African trypanosomiasis. Since the target substance is formed intracellularly (under nutrient limitation), the fungal pellet is preferred compared to the free mycelia in bioreactor cultivation.
Winda Soerjawinata, Shila Prajapati, Isabelle Barth, Xiaohua Lu, Roland Ulber, Thomas Efferth, Percy Kampeis   +6 more
wiley   +1 more source

Assessment of Willingness to Vaccinate Animals, Pay for Vaccination and Its Contributing Factors in Negele‐Arsi, Shashemene and Hawassa, Ethiopia

Veterinary Medicine and Science, Volume 11, Issue 2, March 2025.
•Vaccines prevent various infectious diseases. However, WTV and WTP for vaccination hindered by multiple challenges. •Overall, 38% of respondents reported as WTV, 36% reported as WTP, whereas 75% chose drugs as a control method over vaccines. •Inaccessibility, high price of vaccines and harm caused by vaccines were noted as a challenge.
Alazar Mekonnen Teffera, Yoseph Cherinet Megerssa   +1 more
wiley   +1 more source

Roads diverged in a wood: Proteins and RNAs encoded by cytochrome b (CYTB) gene in health and disease

Clinical and Translational Discovery, Volume 5, Issue 1, February 2025.
The latest groundbreaking study uncovers a dual translation pattern of the CYTB gene, which uses a standard genetic codon at the cytosolic ribosome to encode a novel protein CYTB‐187AA. The CYTB gene also generates long non‐coding RNAs that are engaged in a variety of physiological and pathological processes.
Cijie Du, Baodan Chen, Yile Huang, Wenxi Liang, Ying Hua Su, Xingguo Liu   +5 more
wiley   +1 more source

Trypanosomiasis Expedition to the Congo [PDF]

The American Journal of the Medical Sciences, 1905
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Williams, Memoi r, Norgate
openaire   +2 more sources