Results 91 to 100 of about 476,853 (295)

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Effect of ultraviolet irradiation on susceptibility of serum albumins to trypsin

, 1964
Ultraviolet irradiation converts bovine serum albumin (BSA) and rabbit serum albumin (RS A) into forms much more rapidly hydrolysed by trypsin than the original proteins.
Kleczkowski, A.
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Towards a Quantitative Description of Proteolysis: Contribution of Demasking and Hydrolysis Steps to Proteolysis Kinetics of Milk Proteins

Foods
The hydrolysis of proteins by proteases (proteolysis) plays a significant role in biology and food science. Despite the importance of proteolysis, a universal quantitative model of this phenomenon has not yet been created.
Mikhail M. Vorob’ev
doaj   +1 more source

Some Properties of Low-Molecular Trypsin Inhibitor from Cabbage Seed (Brassica oleracea) [PDF]

, 1993
P(論文)Some properties of the purifled low-molecular trypsin inhibitor (LMTI) from cabbage seed (Brassica oleracea) were investigated. The purified LMTl was homogeneous on the reverse phase HPLC.The molecular weight was about 5,000 and the isoelectoric ...
牛澤, 良美, ワタナベ, サトル, MORISUE, YUUKO, KITAO, SATOSHI, 11305, WATANABE, SATORU, 北尾, 悟, 森末, 裕子, 11289, 11300, 11288, キタオ, サトシ, 11302, 11301, 11304, 11303, 11290, 11292, 11291, ウメダ, ミチコ, 11294, 11293, 11296, 11295, 福澤, 美喜男, モリスエ, ユウコ, UMEDA, MICHIKO, USHIZAWA, YOSHIMI, ウシザワ, ヨシミ, 11298, 11297, 梅田, 美智子, フクザワ, ミキオ, 11299, 渡邉, 悟, FUKUZAWA, MIKIO   +35 more
core  

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Discovery of PD-L1 Peptide Inhibitors from Ascidian Enzymatic Hydrolysates by Affinity Ultrafiltration Coupled to NanoLC-MS/MS

Marine Drugs
Anti-PD-1 and anti-PD-L1 antibodies have achieved great clinical success in cancer immunotherapy, and peptide and small molecule inhibitors of PD-1/PD-L1 binding also attract much attention.
Qiuyang Huang, Xiaoling Zang, Xinyu Jin, Qian Liu, Xin Zhang, Xinyu Li, Lizhen Zhao, Zhihua Lv   +7 more
doaj   +1 more source

Hubungan antara inhibitor enzim pada Sengon dengan pertumbuhan larva Boktor dalam Artificial Diet [PDF]

, 2011
INTRODUCTION. Sengon (Paraserianthes falcataria (L) Nielsen) is widely planted for reforestation programs, especially in establishment of community forest as its timber is utilized for constrction, package box, lighter as well as raw material of pulp and
Flowrensia, Laura
core  

Engineered Nanotopography to Modulate Growth and Signaling of Neuronal Networks

Advanced Functional Materials, EarlyView.
This study examines the interaction between neurons and nanoscale topographies on engineered substrates. Neurons cultured on nanowires, nanopillars and nanoneedles exhibit enhanced neurite outgrowth, form more organized neuronal circuits, and display improved synaptic connectivity, compared to flat substrates.
Hao Nguyen Tran, Kalyan Shobhana, Zlatan Trifunovic, Dan Smith, Michael Stuiber, Chennupati Jagadish, Mirella Dottori, Andrea J. O'Connor, Vini Gautam   +8 more
wiley   +1 more source

Biomimetic Core–Shell Liposome Nanoparticles Deplete Lipoproteins and Enhance the Purity of Extracellular Vesicles from Human Blood

Advanced Functional Materials, EarlyView.
Lipoprotein‐mimicking nanoparticles (SL‐NPs), comprising Fe3O4@SiO2 cores coated with liposomal bilayers, selectively capture lipoproteins through protein corona formation. The resulting SL‐NP‐lipoprotein complexes can be removed by low‐speed centrifugation, thereby enhancing the purity of small extracellular vesicles (sEVs) isolated from human serum ...
Man‐Di Wang, Andrew J. Perciaccante, David Inman, Bong Hwan Sung, Alissa M. Weaver, Suzanne M. Ponik, Ying Ge, Song Jin   +7 more
wiley   +1 more source