SummarySoy and navy bean trypsin inhibitors considerably reduce the incidence of fatal trypsin embolism in rabbits with the retention of marked thromboplastic activity by the inhibitor-enzyme complex. The thromboplastic effect is observed with little or no proteolytic activity and the relative protection against embolism is apparent even with extensive
openaire +3 more sources
Getting intimate with trypsin, the leading protease in proteomics.
Nowadays, mass spectrometry-based proteomics is carried out primarily in a bottom-up fashion, with peptides obtained after proteolytic digest of a whole proteome lysate as the primary analytes instead of the proteins themselves.
E. Vandermarliere+2 more
semanticscholar +1 more source
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash+6 more
wiley +1 more source
Characterisation of serine proteinase inhibitors in dry seeds of cultivated pasture grass species : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Plant Biology and Biotechnology at Massey University, Palmerston North, New Zealand [PDF]
Content removed due to copyright restriction: Tasneem, M., Cornford, C. A., & McManus, M. T. (1994). Characterization of serine proteinase inhibitors in dry seeds of cultivated pasture grass species. Seed Science Research, 4(3), 335-345.
Tasneem, Mohammad
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Action of plant proteinase inhibitors on enzymes of physiopathological importance
Obtained from leguminous seeds, various plant proteins inhibit animal proteinases, including human, and can be considered for the development of compounds with biological activity.
Maria Luiza V. Oliva, Misako U. Sampaio
doaj +1 more source
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh+7 more
wiley +1 more source
Ribonucleoparticle-independent transport of proteins into mammalian microsomes [PDF]
There are at least two different mechanisms for the transport of secretory proteins into the mammalian endoplasmic reticulum. Both mechanisms depend on the presence of a signal peptide on the respective precursor protein and involve a signal peptide ...
Cobet, Werner W. E.+8 more
core +2 more sources
Alpha‐1‐anti‐trypsin deficiency is the most common genetic cause of liver disease in children and liver transplantation is currently the only available treatment.
Nunzia Pastore+14 more
semanticscholar +1 more source
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda+9 more
wiley +1 more source
Preparation Of Conjugated Thermo-Sensitive Poly (Nipam) For Affinity Precipitation Of Enzyme [PDF]
Affinity precipitation is a recent technique for the purification of enzyme. The precipitation is based upon the interaction between a target enzyme and ligand which binds to the enzyme in a specific manner.
Syaubari, Syaubari
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