Results 131 to 140 of about 712,349 (416)

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

Advanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang, Lijuan Zhang, Jiaorong Tan, Fei Li, Yishan Jin, Limei He, Xin Yang   +6 more
wiley   +1 more source

Mogroside IIE Inhibits Digestive Enzymes via Suppression of Interleukin 9/Interleukin 9 Receptor Signalling in Acute Pancreatitis

Frontiers in Pharmacology, 2020
The incidence of pancreatitis (AP) is increasing and there is no specific treatment available. Intracellular digestive enzyme activation is a key event in the pathogenesis of AP downstream of cytosolic calcium overload and impaired autophagy.
Juan Xiao, Juan Xiao, Juan Xiao, Kai Huang, Houmin Lin, Zhijia Xia, Jing Zhang, Dianpeng Li, Junfei Jin, Junfei Jin, Junfei Jin, Junfei Jin   +11 more
doaj   +1 more source

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

Influence of Bean Trypsin Inhibitors on Thromboplastic Properties of Trypsin and Hypochlorite Treated Trypsin.

Experimental Biology and Medicine, 1954
SummarySoy and navy bean trypsin inhibitors considerably reduce the incidence of fatal trypsin embolism in rabbits with the retention of marked thromboplastic activity by the inhibitor-enzyme complex. The thromboplastic effect is observed with little or no proteolytic activity and the relative protection against embolism is apparent even with extensive
openaire   +3 more sources

Getting intimate with trypsin, the leading protease in proteomics.

Mass spectrometry reviews (Print), 2013
Nowadays, mass spectrometry-based proteomics is carried out primarily in a bottom-up fashion, with peptides obtained after proteolytic digest of a whole proteome lysate as the primary analytes instead of the proteins themselves.
E. Vandermarliere, Michael Mueller, L. Martens   +2 more
semanticscholar   +1 more source

3D In Vitro Glioma‐Neuron‐Astrocyte Biomimetic Composites Recapitulate Key Molecular Mechanisms Linked to Glioblastoma Multiforme Pathophysiology

Advanced Functional Materials, EarlyView.
Glioblastoma multiforme is the most devastating and incurable brain tumor. To better study this disease, a 3D model is developed using a hyaluronic acid‐based hydrogel combined with a multicellular approach. This model recapitulates in vivo brain stiffness, cell‐extracellular matrix and cell‐cell interactions and the tumor's hijacking function with the
Mateo S. Andrade Mier, Esra Türker, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Panthipa Suwannakot, Benedikt Gantert, Abhinav Singh, Vanessa Moessler, Annemarie Sodmann, Nicoletta Murenu, Joachim Schenk, Natascha Schaefer, Torsten Blunk, Aldo R. Boccaccini, Tessa C. Lühmann, Jörg Tessmar, Jeremy M. Crook, Eva Tomaskovic‐Crook, Paul D. Dalton, Gregor Lang, Robert Blum, Reiner Strick, Silvia Budday, Katrin G. Heinze, Carmen Villmann   +26 more
wiley   +1 more source

The Potential of Hydrolysate from Rabbit Meat Protein as an Angiotensin Converting Enzyme Inhibitor

Buletin Peternakan, 2019
This research aimed to investigate the rabbit meat hydrolysate potential as an angiotensin-converting enzyme (ACE) inhibitor. Indonesian local rabbit meats were used in this study.
Edy Permadi, Jamhari Jamhari, Edi Suryanto, Zaenal Bachruddin, Yuny Erwanto   +4 more
doaj   +1 more source

Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing

Advanced Functional Materials, EarlyView.
Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan, Ling Li, Celine J. Agnes, Bettina M. Willie, Maryam Tabrizian   +4 more
wiley   +1 more source

Sustained Release of Proteins Using Region‐Specific Tunable Degradability in Hydrogels through 3D Photopatterning and Complimentary Labile Bond Chemistry

Advanced Functional Materials, EarlyView.
A series of ultraviolet‐ and near‐infrared radiation sensitive photoactivatable hydrogels are developed that can be controlled spatiotemporally down to µm precisions using one‐ and two‐photon uncaging. The latent hydroxylamine‐, hydrazine‐, and amine uncaged moieties are used to photopattern a series of diverse proteins displaying complimentary ...
Tove Kivijärvi, Carmine P. Cerrato, Taha Behroozi Kohlan, Paul O’Callaghan, Johan Kreuger, Marie Arsenian‐Henriksson, Anna Finne‐Wistrand   +6 more
wiley   +1 more source

Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency

EMBO Molecular Medicine, 2013
Alpha‐1‐anti‐trypsin deficiency is the most common genetic cause of liver disease in children and liver transplantation is currently the only available treatment.
Nunzia Pastore, K. Blomenkamp, Fabio Annunziata, Pasquale Piccolo, P. Mithbaokar, Rosa Maria Sepe, Francesco Vetrini, D. Palmer, P. Ng, E. Polishchuk, Simona Iacobacci, R. Polishchuk, J. Teckman, A. Ballabio, N. Brunetti‐Pierri   +14 more
semanticscholar   +1 more source