Results 61 to 70 of about 476,853 (295)
The Journal of Poultry Science, 2013 The present study was designed to evaluate whether plum (Prunus mume Siebold and Zucc., PM) products affect growth performance, digestive enzymes, enteric microflora and inflammatory cytokines in growing broiler chicks.
Insurk Jang +2 more
doaj +1 more source
Trypsin inhibitor activity in grass pea seeds (Lathyrus sativus L.) [PDF]
, 2023 Grass pea (Lathyrus sativus) is a valuable grain legume known for its high protein content and rich essential amino acid profile. Its exceptional characteristics such as drought tolerance, high adaptability to extreme conditions, disease resistance, and ...
Isakov, Milada +13 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
, 2019 Nanopore technology is promising for the next-generation of nucleic acid–based diagnosis. However, sequence reservation could still be hardly achieved in low-concentration. Herein, we propose a trypsin-activated catalysis reaction for amplified detection,
Yi Wan (296606) +17 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
NMR solution structure of a chymotrypsin inhibitor from the Taiwan cobra Naja naja atra [PDF]
, 2013 The Taiwan cobra (Naja naja atra) chymotrypsin inhibitor (NACI) consists of 57 amino acids and is related to other Kunitz-type inhibitors such as bovine pancreatic trypsin inhibitor (BPTI) and Bungarus fasciatus fraction IX (BF9), another chymotrypsin ...
Chang, Long-Sen +7 more
core +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Structural information of trypsin isozyme GT-B from grass carp (Ctenopharyngodon idellus) intestines
浙江大学学报. 农业与生命科学版, 2008 In order to learn the correlation between chemical composition, structure and properties of grass carp intestine trypsin isozyme GT-B, the composition of amino acids, characteristic of ultraviolet absorption, and secondary structural units of this enzyme
LIU Zhong-yi +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source