Cleavage of endogenous gamma ENaC and elevated abundance of alpha ENaC are associated with increased Na+ transport in response to apical fluid volume expansion in human H441 airway epithelial cells [PDF]
, 2011 Using human H441 airway epithelial cells cultured at air–liquid interface (ALI), we have uniquely correlated the functional response to apical fluid volume expansion with the abundance and cleavage of endogenous α- and γENaC proteins in the apical ...
Baines, DL, Selvanathar, IA, Tan, CD
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Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies
FEBS Open Bio, EarlyView.Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa +13 more
wiley +1 more source
The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes [PDF]
, 2010 The cuticle of parasitic nematodes performs many critical functions and is essential for proper development and for protection from the host immune response.
Antony P. Page +43 more
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FEBS Open Bio, EarlyView.Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki +11 more
wiley +1 more source
Alimentos e Nutrição, 2011 The trypsin inhibitor, an antinutritional factor, which is abundant in dycotiledoneous and monocotyledoneous, is usually inactivated by heating treatment.
Kelli Cristina PAIVA +2 more
doaj
MOLECULAR PROFILE, PURITY AND PRESENCE OF TRYPSIN INHIBITORS IN COWPEA PROTEIN ISOLATES
Revista Caatinga, 2018 The most-used preparation process of protein isolates (PI) involves the isoelectric precipitation of the protein. Heating shortens the preparation time but this procedure may affect the purity, yield, molecular profile of the protein, and the activity of
KAROLINE DE MACÊDO GONÇALVES FROTA +3 more
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FEBS Open Bio, EarlyView.In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley +1 more source
Acta Universitatis Sapientiae: Alimentaria, 2018 We have developed a new procedure for reducing soy trypsin inhibitor activity by means of heat treatment combined with chemical methods, through which soy trypsin inhibitor activity decreases to the tenth or twentieth part of the original value.
Csapó J., Albert Cs.
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The Diversity of Four Anti-nutritional Factors in Common Bean
Horticultural Plant Journal, 2016 Anti-nutritional factors such as lectins, saponin, trypsin inhibitor and phytic acid are endogenous substances in the common bean (Phaseolus vulgaris L.).
Rui Shang +7 more
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Fehérje-kölcsönhatások szerkezeti alapjainak feltárása és a kölcsönhatás szelektív gátlása irányított evolúciós eljárásokkal = Deciphering the structural basis of protein-protein interactions and their selective inhibition via directed evolutionary methods [PDF]
, 2012 Fő célom az volt, hogy meghonosítsam az irányított fehérjeevolúció szemléletét, és legsikeresebb technológiáját, a fágbemutatást. Egyrészt azt kutattuk, mi szabja meg a proteáz inhibitorok affinitását és specifitását.
Gráf, László +2 more
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