Results 61 to 70 of about 3,419,991 (153)

Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib

Chemistry and Biology, 2011
Summary Proteasomes degrade the majority of proteins in mammalian cells, are involved in the regulation of multiple physiological functions, and are established targets of anti-cancer drugs. The proteasome has three types of active sites.
A. Mirabella, Alexandre A. Pletnev, Sondra L. Downey, B. Florea, T. Shabaneh, M. Britton, M. Verdoes, D. Filippov, H. Overkleeft, A. Kisselev   +9 more
semanticscholar   +1 more source

Inhibitory effect of various recombinant corn trypsin inhibitor variants against trypsin

Zanco Journal of Medical Sciences
Background and objective: Trypsin is best known for playing a role in enteric digestion, among the most commonly examined serine proteases. Trypsin is expressed extra-pancreatically by a number of cancer types (for instance, Ovarian cancer), and it is ...
Badraldin Kareem Hamad
doaj   +1 more source

Trypsin Inhibitor in Guar Meal

Experimental Biology and Medicine, 1966
SummaryThe presence of trypsin inhibitor in Guar meal has been demonstrated by the trypsin-hemoglobin digestion procedure. The level of inhibition is concentration dependent. The inhibitor is destroyed by heating and is apparently not dialyzable, which may be indicative of a macromolecular nature.
J R, Couch, C R, Creger, Y K, Bakshi
openaire   +2 more sources

Streptomyces lavendulae Protease Inhibitor: Purification, Gene Overexpression, and 3-Dimensional Structure

Journal of Chemistry, 2015
Protease inhibitors trypsin (STI1, Streptomyces trypsin inhibitor 1) has been identified, purified by ammonium sulfate precipitation and Sephadex G-100 gel filtration. SDS-PAGE of protease inhibitor showed molecular weight of approximately 10 KDa.
D. E. El-Hadedy, El-Sayed E. Mostafa, Moataza M. Saad   +2 more
doaj   +1 more source

Oligosaccharides, phytate and trypsin inhibitors in sweet lupine seeds (Lupinus angustifolius L.) and commercial products derived from them

Discover Food
Lupine seeds (Lupinus angustifolius) are increasingly recognized as a valuable source of plant-based protein for human nutrition. Similar to other legumes, lupines contain antinutrients.
Benno F. Zimmermann, Timo Heinrichs, Hedwig Heuser, Ismail-Hakkı Acır, Ute Schweiggert-Weisz   +4 more
doaj   +1 more source

A trypsin-like serine protease is involved in pseudorabies virus invasion through the basement membrane barrier of porcine nasal respiratory mucosa

Veterinary Research, 2011
Several alphaherpesviruses breach the basement membrane during mucosal invasion. In the present study, the role of proteases in this process was examined.
Glorieux Sarah, Favoreel Herman W, Steukers Lennert, Vandekerckhove Annelies P, Nauwynck Hans J   +4 more
doaj   +1 more source

The Reactive Site of Trypsin Inhibitors

Journal of Biological Chemistry, 1966
Virgin soybean trypsin inhibitor has 1 NH2-terminal aspartic acid or asparagine residue and no COOH-terminal residues that can be released by carboxypeptidase B. Upon incubation with 1 mole % of trypsin for 24 hours at pH 3.75, virgin inhibitor is converted to a modified inhibitor which has 2 NH2 terminals aspartic acid or asparagine and isoleucine ...
K, Ozawa, M, Laskowski
openaire   +2 more sources

Trypsin inhibitor from starchy endosperm of rye seeds

Acta Societatis Botanicorum Poloniae, 2015
A method for the preparation of a trypsin inhibitor from starchy endosperm of rye seeds is described. Isolation and purification comprised the following steps: salting out of the water-soluble proteins at pH 4.5 with ammonium sulphate (0.4 saturation ...
A. Pawłowski
doaj   +1 more source

Blood Digestion by Trypsin-Like Serine Proteases in the Replete Lyme Disease Vector Tick, Ixodes scapularis

Insects, 2020
Ixodes scapularis is the major vector of Lyme disease in the Eastern United States. Each active life stage (larva, nymph, and adult) takes a blood meal either for developing and molting to the next stage (larvae and nymphs) or for oviposition (adult ...
Jeremiah Reyes, Cuauhtemoc Ayala-Chavez, Arvind Sharma, Michael Pham, Andrew B. Nuss, Monika Gulia-Nuss   +5 more
doaj   +1 more source

A Simple, Quantitative Method for Titration of Trypsin and Trypsin Inhibitors.

Experimental Biology and Medicine, 1949
SummaryA technically simple, rapid method for the quantitative titration of trypsin or similar proteolytic enzymes, and of protease inhibitors, suitable for critical tests on a large scale is described. The procedure utilizes technics familiar to serologists, rather than to skilled biochemists only, and gives definitive, reproducible results that can ...
K L, BURDON, R P, MUDD
openaire   +2 more sources