Results 51 to 60 of about 901,103 (252)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
N-Terminal Amino Acid Sequence of Trypsin Inhibitor from Rape Seeds (Brassica campestris) [PDF]
, 1999 P(論文)N-Terminal amino acid sequence of trypsin inhibitor I (TI-I) from rape seeds was analysed. TI-I was estimated to be hetero-oligomer because the presence of a few N-terminal amino acids were obtained by the analysis of Edman degradation.
ワタナベ, サトル +23 more
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PLoS ONE, 2013 Inhibitors of peptidases isolated from leguminous seeds have been studied for their pharmacological properties. The present study focused on purification, biochemical characterization and anti-inflammatory and anticoagulant evaluation of a novel Kunitz ...
Richele J A Machado +11 more
doaj +1 more source
Biochemistry and Biophysics Reports, 2016 New trypsin inhibitors Z-Lys-COCHO and Z-Lys-H have been synthesised. Ki values for Z-Lys-COCHO, Z-Lys-COOH, Z-Lys-H and Z-Arg-COOH have been determined. The glyoxal group (–COCHO) of Z-Lys-COCHO increases binding ~300 fold compared to Z-Lys-H.
Jennifer A. Cleary, J. Paul G. Malthouse
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Inheritance of qualitative and quantitative trypsin inhibitor variants in Pisum
, 1994 A trypsin inhibitor locus (Tri) has been mapped close to Vc-2 on Pisum (pea) linkage group 5 using recombinant inbred lines derived from crosses of genotypes showing qualitative variation in seed trypsin inhibitors.
Welham, T. +3 more
core +1 more source
Journal of the Indonesian Tropical Animal Agriculture, 2019 This study was aimed to explore their potency of protein-bioactive of native ducks-meat after enzymatic hydrolysis by Bacillus-cereus TD5B-protease, Pepsin, and Trypsin as an angiotensin-converting enzyme (ACE) inhibitor. The samples: ducks-meats from 10
A. Winarti +4 more
doaj +1 more source
Trypsin inhibition by ferrocene [PDF]
Acta Periodica Technologica, 2005 Many transition metals and their complexes show inhibitory effect on someproteolytic enzymes, including trypsin. Their inhibitory activity is based on the direct binding to the active site of trypsin, mimicking formation of a five-coordinate transition ...
Kukrić Zoran Z., Žabić Mirjana M.
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Some Properties of Low-Molecular Trypsin Inhibitor from Cabbage Seed (Brassica oleracea) [PDF]
, 1993 P(論文)Some properties of the purifled low-molecular trypsin inhibitor (LMTI) from cabbage seed (Brassica oleracea) were investigated. The purified LMTl was homogeneous on the reverse phase HPLC.The molecular weight was about 5,000 and the isoelectoric ...
牛澤, 良美 +35 more
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