Results 71 to 80 of about 8,341 (178)

Recent insights about autophagy in pancreatitis

eGastroenterology
Acute pancreatitis is a common inflammatory gastrointestinal disease without any successful treatment. Pancreatic exocrine acinar cells have high rates of protein synthesis to produce and secrete large amounts of digestive enzymes. When the regulation of
Xiaowen Ma, Shaogui Wang, Wen-Xing Ding, Hong-Min Ni, Sydney Kim   +4 more
doaj   +1 more source

Noninvasive rapid urinary trypsinogen‐2 dipstick test for early exclusion of post‐endoscopic retrograde cholangiopancreatography pancreatitis within hours after endoscopic retrograde cholangiopancreatography: Clinical diagnosis and considerations

DEN Open
Objective Few reports have explored the application of urinary trypsinogen‐2 measurement in the early diagnosis of post‐endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, and none have demonstrated the benefits of noninvasive testing ...
Kazuki Hama, Atsushi Sofuni, Ryosuke Nakatsubo, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Shuntaro Mukai, Kenjiro Yamamoto, Akio Katanuma, Takao Itoi   +9 more
doaj   +1 more source

Heterozygous Spink1 Deficiency Promotes Trypsin-dependent Chronic Pancreatitis in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Heterozygous SPINK1 mutations are strong risk factors for chronic pancreatitis in humans, yet heterozygous disruption of mouse Spink1 yielded no pancreatic phenotype.
Alexandra Demcsák, Miklós Sahin-Tóth
doaj   +1 more source

Translational arrest due to cytoplasmic redox stress delays adaptation to growth on methanol and heterologous protein expression in a typical fed-batch culture of Pichia pastoris.

PLoS ONE, 2015
ResultsWe have followed a typical fed-batch induction regime for heterologous protein production under the control of the AOX1 promoter using both microarray and metabolomic analysis.
Bryn Edwards-Jones, Rochelle Aw, Geraint R Barton, Gregory D Tredwell, Jacob G Bundy, David J Leak   +5 more
doaj   +1 more source

The action of enterokinase on trypsinogen [PDF]

Biochimica et Biophysica Acta, 1956
Ikuo Yamashina, Börje Östman, John G. Ormerod, Einar Stenhagen, B. Thorell   +4 more
openaire   +3 more sources

CONCERNING TRYPSINOGEN [PDF]

Proceedings of the National Academy of Sciences, 1965
openaire   +2 more sources

Heat Shock Proteins and Autophagy in Rats with Cerulein-Induced Acute Pancreatitis

Gut and Liver, 2011
Background/AimsHeat shock proteins (HSPs) protect rats from cerulein-induced acute pancreatitis (AP) by preventing the subcellular redistribution of cathepsin B and the activation of trypsinogen.
doaj   +1 more source

The Molecular Weight of Trypsinogen

Journal of Biological Chemistry, 1961
C M, KAY, L B, SMILLIE, F A, HILDERMAN
openaire   +2 more sources

Activation of Trypsinogen by Plasmin.

Experimental Biology and Medicine, 1967
M V, Goldblat, D L, Kline, J H, Milstone
openaire   +2 more sources

Research progress on the mechanisms of cathepsin B in pancreatitis

生物医学转化
Cathepsin B (CTSB) is a key lysosomal cysteine protease that plays a critical role in the pathogenesis and progression of pancreatitis. CTSB not only activates trypsinogen to induce acinar cell self-digestion, but also enhances the pro-inflammatory ...
Liu Xuan, Xu Xiaofan, Wang Yuanchen, Wang Lei, Zou Wenbin   +4 more
doaj   +1 more source