Results 51 to 60 of about 8,341 (178)
Microbial Cell FactoriesBackground Trypsinogen and chymotrypsinogen are serine proteases with potential therapeutic applications in cancer. However, due to ethical, safety and variability concerns, their clinical use has been limited by the reliance on bovine or porcine ...
Aitor González-Titos +7 more
doaj +1 more source
AEG‐AESPANC‐OPGE‐SIED‐SPG Ibero‐Latin American Guidelines on Acute Pancreatitis (iLATAM‐AP)
United European Gastroenterology Journal, Volume 14, Issue 5, June 2026.ABSTRACT Introduction Acute pancreatitis (AP) is a major cause of gastrointestinal hospitalizations worldwide. Although typically self‐limiting, up to one‐third of cases develop complications associated with increased morbidity and mortality. Despite recent advances that have improved outcomes, clinical heterogeneity necessitates updated, evidence ...
Karina Cárdenas‐Jaén +44 more
wiley +1 more source
Mass spectrometric detection of tyrosine sulfation in human pancreatic trypsinogens, but not in tumor‐associated trypsinogen [PDF]
The FEBS Journal, 2007 Trypsinogen‐1 and ‐2 are well‐characterized enzymes that are expressed in the pancreas and also in several other tissues. Many cancers produce trypsinogen isoenzymes that differ from the pancreatic ones with respect to substrate specificity and isoelectric point.
Outi, Itkonen +6 more
openaire +2 more sources
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Clearance of cerebral Aβ was primarily mediated by the brain endothelial transporters including LRP1. The regulatory mechanism of LRP1 expression remained unclear. METHODS LRP1 in brain endothelial cells treated with pro‐CTSD were analyzed by western blot.
Zhi‐Jun Li +12 more
wiley +1 more source
Pest Management Science, Volume 82, Issue 5, Page 4632-4647, May 2026.XXXX Abstract BACKGROUND Spodoptera frugiperda, commonly known as the fall armyworm, is a highly economically significant pest that affects various crops, resulting in substantial losses in productivity. Managing this pest primarily relies on chemical insecticides; however, the repeated development of resistance to these chemicals has rendered them ...
Daniel Guimarães Silva Paulo +9 more
wiley +1 more source
Haematologica, 2019 Asparaginase-associated pancreatitis is a life-threatening toxicity to childhood acute lymphoblastic leukemia treatment. To elucidate genetic predisposition and asparaginase-associated pancreatitis pathogenesis, ten trial groups contributed remission ...
Benjamin O. Wolthers +23 more
doaj +1 more source
Clinical Transplantation, Volume 40, Issue 5, May 2026.ABSTRACT Background Total pancreatectomy with islet auto‐transplantation (TPIAT) alleviates pain and preserves islet function in patients with severe pancreatitis. Although approximately one third of recipients achieve insulin independence, spontaneous hypoglycemia has been observed in this population. Its frequency, risk factors, and management remain
Azza Hassaan +10 more
wiley +1 more source
SVU - International Journal of Medical SciencesBackground: Acute pancreatitis is one of the most serious complications of ERCP. Early diagnosis of post-ERCP pancreatitis (PEP) helps physicians to provide intensive care and possible medical treatment as early as possible.
Ahlam Mohammed Sabra +4 more
doaj +1 more source
Trypsinogen activation peptide induces HMGB1 release from rat pancreatic acinar cells
Open Medicine, 2017 The development of acute pancreatitis (AP) is associated with intracellular events in pancreatic cells, as well as with early and late inflammatory responses; however, their underlying mechanisms remain unclear.
Wang Guoliang +6 more
doaj +1 more source
Preclinical testing of dabigatran in trypsin-dependent pancreatitis
JCI Insight, 2022 Pancreatitis, the inflammatory disorder of the pancreas, has no specific therapy. Genetic, biochemical, and animal model studies revealed that trypsin plays a central role in the onset and progression of pancreatitis.
Zsófia Gabriella Pesei +5 more
doaj +1 more source