Results 111 to 120 of about 5,000 (229)

The Endogenous Hallucinogen and Trace Amine N,N-Dimethyltryptamine (DMT) Displays Potent Protective Effects against Hypoxia via Sigma-1 Receptor Activation in Human Primary iPSC-Derived Cortical Neurons and Microglia-Like Immune Cells [PDF]

, 2016
N,N-dimethyltryptamine (DMT) is a potent endogenous hallucinogen present in the brain of humans and other mammals. Despite extensive research, its physiological role remains largely unknown.
Djurovic, Srdjan, Frecska, Ede, Kovács, Attila István, Rajnavölgyi, Éva, Riba, Jordi, Szabó, Attila   +5 more
core   +1 more source

AlkaPlorer: A database‐driven explorer for natural alkaloids and derivatives

Journal of Integrative Plant Biology, EarlyView.
The alkaloid database AlkaPlorer integrates over 130,000 compounds across 12,250 species. By linking chemical structures with biological and evolutionary data, it reveals how these molecules evolve and function. This platform serves as a vital resource for AI‐driven discovery in plant metabolism and modern drug development. ABSTRACT Alkaloids, renowned
Jiahao Li, Tao Zeng, Hongquan Xu, Xu Kang, Minghui Liang, Ruibo Wu   +5 more
wiley   +1 more source

The use of a quantitative structure-activity relationship (QSAR) model to predict GABA-A receptor binding of newly emerging benzodiazepines [PDF]

, 2018
The illicit market for new psychoactive substances is forever expanding. Benzodiazepines and their derivatives are one of a number of groups of these substances and thus far their number has grown year upon year.
Haegeman, Caroline, Haider, Shozeb, Manchester, Kieran R., Maskell, Peter D., Waters, Laura   +4 more
core   +5 more sources

Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene‐Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus

Plant Biotechnology Journal, EarlyView.
ABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Bofu Deng, Qing Miao, Chaoqin Ou, Yuanbing Pan, Hang Liu, Xueqing Fu, Ling Li, Yuliang Wang, Kexuan Tang, Qifang Pan   +9 more
wiley   +1 more source

Asymmetric fluorinative dearomatization of tryptamine derivatives

Chemical Communications, 2017
An asymmetric fluorinative dearomatization reaction of tryptamine derivatives was developed by using a chiral anion phase transfer catalytic system.
Xiao-Wei Liang, Chuan Liu, Wei Zhang, Shu-Li You   +3 more
openaire   +3 more sources

Glucuronoyl Esterase of Pathogenic Phanerochaete carnosa Induces Immune Responses in Aspen Independently of Its Enzymatic Activity

Plant Biotechnology Journal, EarlyView.
ABSTRACT Microbial enzymes expressed in plants add new functionalities but occasionally trigger undesirable immune responses. Phanerochaete carnosa glucuronoyl esterase (PcGCE) hydrolyses the bond between lignin and 4‐O‐methyl‐α‐D‐glucuronic acid substituent of glucuronoxylan.
Evgeniy N. Donev, Marta Derba‐Maceluch, Xiao‐Kun Liu, Henri Colyn Bwanika, Izabela Dobrowolska, Mohit Thapa, Joanna Leśniewska, Jan Šimura, Alex Yi‐Lin Tsai, Konrad S. Krajewski, Dan Boström, Leszek A. Kleczkowski, Maria E. Eriksson, Karin Ljung, Emma R. Master, Ewa J. Mellerowicz   +15 more
wiley   +1 more source

Enzymatic oxidation of substituted tryptamines catalysed by monoamine oxidase

Nukleonika, 2014
The enzymatic deamination of 5-fl uorotryptamine and 5-hydroxytryptamine, 5-HT, catalysed by enzyme monoamine oxidase A (MAO-A, EC 1.4.3.4) was investigated using the kinetic (KIE) and solvent (SIE) isotope effects methods.
Dragulska Sylwia, Kańska Marianna
doaj   +1 more source

Tandem MADS‐Box Genes FUL2 and MADS1 Form a Regulatory Module to Repress Serotonin Biosynthesis via Direct ASMT5 Activation in Tomato Fruit

Plant Biotechnology Journal, EarlyView.
ABSTRACT The regulation of serotonin metabolism during fruit development and ripening remains poorly understood, despite its potential roles in plant defence and human nutrition. Here, we demonstrated that the MADS‐box transcription factor FUL2 acts as a key repressor of serotonin accumulation in tomato by forming a functional module with MADS1. CRISPR‐
Yaping Xu, Huimin Jia, Dengguo Tang, Lijun Zhang, Xinqin Liu, Junjie Rong, Yunai Lv, Zhaobo Lang, Qingfeng Niu   +8 more
wiley   +1 more source

Three Closely Related Spodoptera Species Similarly Affect Gene Expression and Phytohormone Levels but Differentially Induce Volatile Emissions in Maize

Plant, Cell &Environment, EarlyView.
ABSTRACT Plants can perceive specific elicitors in the oral secretions (OS) of herbivorous insects and respond by increasing their defences. Whether plants can discriminate among similar herbivorous insect species and differentially modulate their defence responses against them is largely unknown.
Wenfeng Ye, Sara Leite Dias, Marine Mamin, Carla C. M. Arce, Ted C. J. Turlings   +4 more
wiley   +1 more source

Metagenomic and biogenic amine changes in cassava fermentation for tucupi production using Pediococcus acidilactici starter culture

Journal of the Science of Food and Agriculture, Volume 106, Issue 4, Page 2424-2436, 15 March 2026.
Abstract BACKGROUND The use of starter cultures is essential for producing fermented foods with desirable standardized characteristics and for preventing pathogens. Pediococcus acidilactici, isolated from cocoa fermentation, was used in the production of tucupi, a widely appreciated sauce made from the juice of cassava root (manipueira) in the ...
Danielle Gama Brício, Maria Beatriz A Gloria, José Augusto Pires Bitencourt, Leandro Araujo Argôlo, Rafaela de Lima Ribeiro, Ilzane Abreu da Silva, Rosinelson da Silva Pena, Alessandra Santos Lopes, Gilson CA Chagas Junior, Nelson Rosa Ferreira   +9 more
wiley   +1 more source