Results 41 to 50 of about 2,854 (189)

Rumors of Psychedelics, Psychotropics and Related Derivatives in Vachellia and Senegalia in Contrast with Verified Records in Australian Acacia

open access: yesPlants, 2022
There are almost 1000 species of Acacia sensu stricto in Australia, while the 44 species and 4 subspecies in southern Africa were taxonomically revised in the year 2011 to Senegalia and Vachellia.
Nicholas J. Sadgrove
doaj   +1 more source

TWO KINDS OF TRYPTAMINE RECEPTOR [PDF]

open access: yesBritish Journal of Pharmacology and Chemotherapy, 1957
There are two kinds of tryptamine receptor in the guinea‐pig ileum, namely the M receptors which can be blocked with morphine and the D receptors which can be blocked with dibenzyline. Atropine, an atropine‐like drug, cocaine, and methadone inhibit effects due to the M receptors, even after dibenzyline, but have no additional effect after morphine ...
J H, GADDUM, Z P, PICARELLI
openaire   +3 more sources

Bis(4-acetoxy-N,N-dimethyltryptammonium) fumarate: a new crystalline form of psilacetin, an alternative to psilocybin as a psilocin prodrug

open access: yesActa Crystallographica Section E: Crystallographic Communications, 2019
The title compound (systematic name: bis{2-[4-(acetyloxy)-1H-indol-3-yl]ethan-1-aminium} but-2-enedioate), 2C14H19N2O2+·C4H2O42−, has a single protonated psilacetin cation and one half of a fumarate dianion in the asymmetric unit.
Andrew R. Chadeayne   +2 more
doaj   +1 more source

Construction of a predictive model for the design of triptamin analogues with potential activity in Parkinson's and Alzheimer's diseases

open access: yesInformatics in Medicine Unlocked, 2023
A growing public health issue has been caused by the diagnosis of neurodegenerative pathologies in millions of people. These conditions are caused by the progressive degeneration of brain cells, which results in the loss of synaptic connections between ...
Santiago Pirela-Ocando   +2 more
doaj   +1 more source

Foxy, a Designer Tryptamine Hallucinogen* [PDF]

open access: yesJournal of Analytical Toxicology, 2003
Foxy is slang for 5-methoxy-N,N-diisopropyltryptamine. It has hallucinogenic properties, similar to other tryptamine compounds, and is mildly euphoric. This case report describes a 21-year-old Caucasian man who ingested a pill called Foxy containing an unknown amount of drug.
Robert, Meatherall, Pankaj, Sharma
openaire   +2 more sources

Monitoring and Mitigation Strategies for Hazardous Compounds in Chinese Rice Wine (Huangjiu): A Comprehensive Review

open access: yesFood Safety and Health, EarlyView.
This review elucidates the formation pathways and detection technologies for ethyl carbamate, biogenic amines, and higher alcohols in Huangjiu. It concludes that integrated control frameworks are essential to decouple safety risks from the metabolic processes responsible for flavor development.
Lulu Liu   +5 more
wiley   +1 more source

Consecutive Four-Component Coupling-Addition Aza-Anellation PictetSpengler Synthesis of Tetrahydro-β-Carbolines: An Optimized Michael Addition and Computational Study on the Aza-Anellation Step

open access: yesOrganics, 2023
Starting from acid chlorides, alkynes, tryptamines, and acryloyl chloride, 21 densely substituted tetrahydro-β-carbolines were prepared in a four-component, one-pot reaction.
Kai Ries   +2 more
doaj   +1 more source

Microbial keystone taxa and metabolic signatures in centenarians regulate intestinal homeostasis during aging

open access: yesiMeta, EarlyView.
Clostridium scindens and its metabolite indole‐3‐acetic acid (IAA) are identified as a keystone taxon and metabolic signature in centenarians. Clostridium scindens enhances microbial network stability and produces IAA via its own amidase (AMIE) and aldehyde dehydrogenase (ALDH), thus promoting intestinal homeostasis by activating the aryl hydrocarbon ...
Wei‐Chuan Lin   +13 more
wiley   +1 more source

PRESSOR EFFECTS OF TRYPTAMINE ANALOGUES [PDF]

open access: yesBritish Journal of Pharmacology, 1976
Methylation of tryptamine in the 1‐position had little effect on the potency of the drug as a pressor agent in the intact anaesthetized rat. In contrast, substitution of a benzo[b]thiophene ring system for the indole ring decreased the pressor activity. Pretreatment of the animals with reserpine reduced the pressor effect of tryptamine and its benzo[b]
T R, Bosin, E J, Hixson, R P, Maickel
openaire   +2 more sources

5‐Methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial

open access: yesAddiction, EarlyView.
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden   +10 more
wiley   +1 more source

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