Results 31 to 40 of about 2,867 (194)

Exploring Endogenous Tryptamines: Overlooked Agents Against Fibrosis in Chronic Disease? A Narrative Review

Livers
Long regarded as illicit substances with no clinical value, N-dimethylated tryptamines—such as N,N-dimethyltryptamine, 5-methoxy-N,N-dimethyltryptamine, and bufotenine—have been found to produce naturally in a wide variety of species, including humans ...
Hunter W. Korsmo
doaj   +1 more source

5-MeO-DALT: the freebase of N,N-diallyl-5-methoxytryptamine

IUCrData, 2020
The title compound {systematic name: N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-(prop-2-en-1-yl)prop-2-en-1-amine), C17H22N2O, has a single tryptamine molecule in the asymmetric unit.
Andrew R. Chadeayne, Duyen N. K. Pham, James A. Golen, David R. Manke   +3 more
doaj   +1 more source

Quaternary tryptammonium salts: N,N-dimethyl-N-n-propyltryptammonium (DMPT) iodide and N-allyl-N,N-dimethyltryptammonium (DMALT) iodide

Acta Crystallographica Section E: Crystallographic Communications, 2020
The solid-state structures of two quaternary trytpammonium salts, namely, N,N-dimethyl-N-n-propyltryptammonium (DMPT) iodide [systematic name: 2-(1H-indol-3-yl)-N,N-dimethyl-N-propylazanium iodide], C15H23N2+·I−, and N-allyl-N,N-dimethyltryptammonium ...
Andrew R. Chadeayne, Duyen N. K. Pham, James A. Golen, David R. Manke   +3 more
doaj   +1 more source

Organocatalytic asymmetric synthesis of bioactive hexahydropyrrolo[2,3-b]indole-containing tetrasubstituted allenes bearing multiple chiral elements

Tetrahedron Chem, 2022
An organocatalytic asymmetric construction of hexahydropyrrolo[2,3-b]indole-containing tetrasubstituted allene scaffolds bearing both axial chirality and central chirality has been established via a cascade 1,8-addition/dearomatization-cyclization ...
Jing-Yi Wang, Shuming Zhang, Xian-Yang Yu, Yu-Hao Wang, Hong-Lin Wan, Shu Zhang, Wei Tan, Feng Shi   +7 more
doaj   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Correlation of Tryptamine-Induced Convulsions in Rats with Brain Tryptamine Concentration

Experimental Biology and Medicine, 1960
SummaryNormal rat brain tryptamine concentration was 0.032 ± 0.002 μg/g (mean ± S.E.M.). Oral administration of 0.72 mg/ kg of tranylcypromine (trans 2-phenylcyclopropylamine) or 25 mg/kg of iproniazid (1-isonicotinyl-2-isopropyl hydrazine) had no apparent effect upon normal rat brain tryptamine concentration. Sixty to 75 seconds after i.v.
H, GREEN, J L, SAWYER
openaire   +2 more sources

Single‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development

Advanced Science, EarlyView.
Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng   +9 more
wiley   +1 more source

N-Methyl-N-propyltryptamine (MPT)

IUCrData, 2019
The title compound {systematic name: [2-(1H-indol-3-yl)ethyl](methyl)propylamine}, C14H20N2, has a single molecule in the asymmetric unit. The molecules in the unit cell are held together in infinite one-dimensional chains along [010] through N—H...N ...
Andrew R. Chadeayne, James A. Golen, David R. Manke   +2 more
doaj   +1 more source

Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production

Frontiers in Immunology, 2021
The liver is the central hub for processing and maintaining homeostatic levels of dietary nutrients especially essential amino acids such as tryptophan (Trp).
Soumya R. Mohapatra, Ahmed Sadik, Suraj Sharma, Gernot Poschet, Hagen M. Gegner, Tobias V. Lanz, Tobias V. Lanz, Tobias V. Lanz, Philippe Lucarelli, Ursula Klingmüller, Ursula Klingmüller, Michael Platten, Michael Platten, Ines Heiland, Christiane A. Opitz, Christiane A. Opitz   +15 more
doaj   +1 more source

Durch anomere Amide ermöglichte divergente Synthese unsymmetrischer Harnstoffe, Carbamate, Thioester und Amide aus Aldehyden

Angewandte Chemie, EarlyView.
Eine divergente Aldehyd‐Funktionalisierungssequenz, ermöglicht durch ein anomeres Amid, erlaubt den Ein‐Topf‐Zugang zu unsymmetrischen Harnstoffen, Carbamaten, Thiocarbamaten, Thioestern und Amiden. Entscheidend für diese Transformation ist die Bildung von N‐Boc‐Hydroxamat‐Intermediaten, die als Plattformen für eine orthogonale Aktivierung über Lossen ...
Jasper L. Tyler, Meiyi Zeng, Julius Wiener, Marie‐Christin Leusmann, Colin Stein, Constantin G. Daniliuc, Frank Glorius   +6 more
wiley   +1 more source