Results 61 to 70 of about 5,000 (229)

Toward personalized healthcare: Advances in two‐dimensional nanomaterial‐based flexible electrochemical sensors for physiological monitoring

open access: yesBMEMat, EarlyView.
This review provides an overview of the properties, composites and application of two‐dimensional (2D) nanomaterials for wearable electrochemical biosensors. Also, the challenges and future prospects of utilizing 2D nanomaterials in wearable electrochemical biosensor applications are discussed.
Kou Zhang   +8 more
wiley   +1 more source

Construction of a predictive model for the design of triptamin analogues with potential activity in Parkinson's and Alzheimer's diseases

open access: yesInformatics in Medicine Unlocked, 2023
A growing public health issue has been caused by the diagnosis of neurodegenerative pathologies in millions of people. These conditions are caused by the progressive degeneration of brain cells, which results in the loss of synaptic connections between ...
Santiago Pirela-Ocando   +2 more
doaj   +1 more source

A copper-catalyzed arylation of tryptamines for the direct synthesis of aryl pyrroloindolines [PDF]

open access: yes, 2012
An operationally simple, copper-catalyzed arylation of N-tosyltryptamines provides direct access to C3-aryl pyrroloindolines. A range of electron-donating and electron-withdrawing substituents is tolerated on both the indole backbone and the aryl ...
Chuang, Kangway V.   +2 more
core   +1 more source

The Relationship Between Premorbid Weight Status and Eating Disorder Onset in Adolescents: A Longitudinal Study

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Adolescents with higher weight status (HWS; body mass index > 85th percentile adjusted for age and sex) are at greater risk of eating disorders (ED). This study examined factors associated with HWS adolescents' increased risk and how weight status interacts with other risk factors to influence ED onset. Method Australian adolescents (
Gabriela Tavella   +5 more
wiley   +1 more source

Consecutive Four-Component Coupling-Addition Aza-Anellation PictetSpengler Synthesis of Tetrahydro-β-Carbolines: An Optimized Michael Addition and Computational Study on the Aza-Anellation Step

open access: yesOrganics, 2023
Starting from acid chlorides, alkynes, tryptamines, and acryloyl chloride, 21 densely substituted tetrahydro-β-carbolines were prepared in a four-component, one-pot reaction.
Kai Ries   +2 more
doaj   +1 more source

Toxicology and Analysis of Psychoactive Tryptamines [PDF]

open access: yesInternational Journal of Molecular Sciences, 2020
Our understanding of tryptamines is poor due to the lack of data globally. Tryptamines currently are not part of typical toxicology testing regimens and their contribution to drug overdoses may be underestimated. Although their prevalence was low, it is increasing.
Sara Malaca   +5 more
openaire   +2 more sources

Formal Synthesis of the Akuammiline Alkaloid (±)‐Strictamine via a (4 + 2) Annulation Reaction With a Donor–Acceptor Cyclobutane

open access: yesHelvetica Chimica Acta, EarlyView.
We report a concise formal synthesis of (±)‐strictamine via a silylium‐catalyzed (4 + 2) annulation of a donor–acceptor cyclobutane, achieved in 13 steps from tryptamine. ABSTRACT The akuammiline alkaloids are complex monoterpene indole natural products with a rigid cage‐like architecture and diverse biological activities.
Clément Tanguy   +2 more
wiley   +1 more source

Analytical characterization of N,N-diallyltryptamine (DALT) and 16 ring-substituted derivatives [PDF]

open access: yes
Many N,N-dialkylated tryptamines show psychoactive properties in humans and the number of derivatives involved in multidisciplinary areas of research has grown over the last few decades.
Brandt, SD   +7 more
core   +1 more source

Proposal of 5-methoxy-N-methyl-N-isopropyltryptamine consumption biomarkers through identification of in vivo metabolites from mice [PDF]

open access: yes, 2017
New psychoactive substances (NPS) are a new breed of synthetically produced substances designed to mimic the effects of traditional illegal drugs. Synthetic cannabinoids and synthetic cathinones are the two most common groups, which try to mimic the ...
Barneo-Muñoz, Manuela   +5 more
core   +2 more sources

Molecular imprinting for neurology: Materials, applications, and limitations

open access: yesIbrain, EarlyView.
Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma   +3 more
wiley   +1 more source

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