Addiction, EarlyView.Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden +10 more
wiley +1 more source
4-Hydroxy-N,N-diisopropyltryptammonium hydrofumarate
IUCrDataThe solid-state structure of the title salt, C16H25N2O+·C4H3O4− {systematic name: [2-(4-hydroxy-1H-indol-3-yl)ethyl]bis(propan-2-yl)azanium (2E)-3-carboxyprop-2-enoate}, is reported.
Marilyn Naeem +3 more
doaj +1 more source
Market Analysis of Synthetic Drugs: Amphetamine-type Stimulants, New Psychoactive Substances [PDF]
, 2017 An estimated quarter of a billion people, or around 5 per cent of the global adult population, used drugs at least once in 2015. Even more worrisome is the fact that about 29.5 million of those drug users, or 0.6 per cent of the global adult population ...
core
Addiction, EarlyView.Abstract Background and aims While the health hazards of synthetic cannabinoid receptor agonists (SCRAs) are often approximated using in vitro pharmacological parameters as surrogate, this approach fails to consider pharmacokinetic and pharmacodynamic complexity.
Michaela J. Sommer +3 more
wiley +1 more source
Metabolism of the new psychoactive substances N,N-diallyltryptamine (DALT) and 5-methoxy-DALT and their detectability in urine by GC-MS, LC-MS (n) , and LC-HR-MS-MS [PDF]
N,N-Diallyltryptamine (DALT) and 5-methoxy-DALT (5-MeO-DALT) are synthetic tryptamine derivatives commonly referred to as so-called new psychoactive substances (NPS).
Brandt, SD +4 more
core +1 more source
Trends in fentanyl‐containing drug samples seized by law enforcement agencies across Canada
Addiction, EarlyView.Abstract Background and aims Canada's drug toxicity crisis has been largely attributed to a volatile fentanyl‐dominated unregulated drug supply with increasing reports of fentanyl detected in combination with benzodiazepines, stimulants and xylazine.
Shaleesa Ledlie +6 more
wiley +1 more source
Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels [PDF]
, 2018 Drugs do not act solely by canonical ligand–receptor binding interactions. Amphiphilic drugs partition into membranes, thereby perturbing bulk lipid bilayer properties and possibly altering the function of membrane proteins.
Aldrich, Richard W. +12 more
core +2 more sources
Artificial Organs, EarlyView.Stroke induces mitochondrial dysfunction and motor disorders. FES combined with physical exercises can help restore mitochondrial function by regulating the formation of reactive oxygen species and, consequently, contributing to functional recovery. ABSTRACT Background Stroke is commonly accompanied by motor disorders secondary to the initial injury ...
A. Larrea +5 more
wiley +1 more source
Effect of oral tryptamines on the gut microbiome of rats—a preliminary study [PDF]
PeerJBackground Psilocybin and related tryptamines have come into the spotlight in recent years as potential therapeutics for depression. Research on the mechanisms of these effects has historically focused on the direct effects of these drugs on neural ...
Mengyang Xu +4 more
doaj +2 more sources
C7-Derivatization of C3-Alkylindoles Including Tryptophans and Tryptamines [PDF]
, 2014 A versatile strategy for C7-selective boronation of tryptophans, tryptamines, and 3-alkylindoles by way of a single-pot C2/C7-diboronation–C2-protodeboronation sequence is described. The combination of a mild iridium-catalyzed C2/C7-diboronation followed
Amaike, Kazuma +5 more
core +2 more sources