Results 71 to 80 of about 1,553 (208)

Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma

, 2014
BackgroundTryptase, a major secretory product of human mast cells has been implicated as a key mediator of allergic inflammation. Genetic variation in the tryptases is extensive, and ?-tryptase, an allelic variant of the more extensively studied ...
A. F. Walls, Abdelmotelb, A.M., Holloway, J.W., S. J. Barton, Rose-Zerilli, M.J., A. M. Abdelmotelb, Barton, S.J., M. J. Rose‐Zerilli, J. W. Holloway, Holgate, S.T., S. T. Holgate, Walls, A.F.   +11 more
core   +1 more source

Mast cell tryptase, a potent inflammatory mediator, requires heparin for enzymatic activation [PDF]

, 2007
Mast cell tryptase, a tetrameric serine protease stored in mast cell granules in complex with heparin proteoglycan or chondroitin sulphate proteoglycan, is an important effector molecule in inflammatory reactions like allergies and asthma.
Lindahl, Susanne
core   +1 more source

Tryptase Locus Variation Contributes to Normal‐Range Basal Serum Tryptase Variability and Is Associated With Anaphylaxis

Clinical &Experimental Allergy, EarlyView.
Tryptase locus variation explains normal‐range baseline serum tryptase differences and is associated with Hymenoptera venom anaphylaxis, independent of clonal mast cell disease and HαT. ABSTRACT Background Increased basal serum tryptase level (BST) is associated with anaphylaxis.
Manca Svetina, Jonathan J. Lyons, Peter Kopač, Julij Šelb, Mitja Košnik, Matija Rijavec, Peter Korošec   +6 more
wiley   +1 more source

Proteolytic enzymes of thermophilic bacteria-part I

, 1946
1. The thermophilic bacteria Bacillus thermophilus, B. aerothermophilus andB. thermoacidurans produce powerful proteinases which can be detected in the culture filtrates. 2.
Chopra, N. N., N. N. Chopra
core   +1 more source

Impact of Hymenoptera venom allergy and the effects of specific venom immunotherapy on mast cell metabolites in sensitized children

Annals of Agricultural and Environmental Medicine, 2014
introduction and objective. Mast cells (MC) are effector cells during severe systemic reactions (SR) to Hymenoptera stings. Venom specific immunotherapy (VIT) is the treatment of choice for prevention of SR to stings. Tryptase and prostaglandin D[sub]2[
Ewa Cichocka-Jarosz, Marek Sanak, Andrzej Szczeklik , Piotr Brzyski, Jacek J. Pietrzyk   +4 more
doaj  

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, EarlyView.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source

ICSH Guidance on Bone Marrow Examination and Reporting

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Examination of the bone marrow (BM) remains fundamental to the diagnosis, classification, prognostication, and monitoring of hematolymphoid and other disorders affecting blood cell production. Since publication of the International Council for Standardization in Haematology (ICSH) guideline in 2008, advances in diagnostic technologies, disease
Wendy N. Erber, Alexandar Tzankov, Olga Pozdnyakova, Hiromichi Matsushita, Gina Zini, Leonie Saft, on behalf of the International Council for Standardization in Haematology   +6 more
wiley   +1 more source

Algorithms in Allergy: Diagnosis of Hypereosinophilic Syndromes, 2026 Update

Allergy, EarlyView.
Guillaume Lefèvre, Florence Roufosse, Giacomo Emmi, Andreas Reiter, Emmanuel Ledoult, Jean‐Emmanuel Kahn   +5 more
wiley   +1 more source

Management of chronic urticaria: Current status and future prospect

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Chronic urticaria is driven by mast cell activation through autoimmune, inflammatory, and neuroimmune pathways. A structured approach combining diagnosis, patient‐reported outcomes, stepwise therapy, treatment optimization, monitoring and emerging targeted agents may improve disease control and enable more personalized management.
Andaç Salman, Mona Al‐Ahmad, Maryam Al‐Nesf, Chia‐Yu Chu, Luis Felipe Ensina, Ana M. Gimenez‐Arnau, Margarida Gonçalo, Clive Grattan, Michihiro Hide, Pavel Kolkhir, Martin Metz, Iman Nasr, Romi Saini, Simon Francis Thomsen, Torsten Zuberbier, Emek Kocaturk   +15 more
wiley   +1 more source

Cutting Edge – Cleavage Specificity and Biochemical Characterization of Mast Cell Serine Proteases [Elektronisk resurs]

, 2003
It is well established that mast cells (MC) are key players in airway pathologies such as allergic asthma, but they are also known to contribute to host defense and tissue remodeling.
Hellman, Lars, Gullberg, Urban,, Karlson, Ulrika,   +2 more
core   +4 more sources