Results 51 to 60 of about 1,553 (208)

rmMCP-6 and 7 induce tube formation by endothelial cells.

, 2015
SVEC4-10 cells were cultured for 5 hours at 37°C on Geltrex® in the presence of rmMCP-6 (A), rmMCP-7 (B) or in the absence of tryptases (C). (A) In the presence of rmMCP-6 most of the SVEC4-10 cells were spread on the substrate, tube formation was ...
Maria Célia Jamur (79424), Devandir Antonio de Souza Junior (833396), Constance Oliver (35853), Antonio Carlos Borges (833397), Ana Carolina Santana (833398)   +4 more
core   +1 more source

Human Lung Mast Cell Tryptase Isozymes: Separation and Examination of Structural and Functional Differences [PDF]

, 1993
Tryptases are trypsin-like enzymes found in mast cell granules. Although in vivo substrates have not been positively identified, tryptases cleave a limited number of potential physiological substrates in vitro, including high molecular weight kininogen ...
Little, Susan S.
core   +1 more source

Genetic, morphological and functional characteristics of human tryptase

Аллергология и Иммунология в Педиатрии
Introduction. Tryptase, a mast cell-derived protease, plays a significant role in the diagnosis and pathogenesis of allergic and inflammatory diseases.
N. E. Tarasova, A. A. Lebedenko, O. E. Semernik, N. M. Dobaeva, V. O. Skosar, N. Yu. Haygetyan, I. P. Krivokhlyabov, S. P. Shkilnyuk   +7 more
doaj   +1 more source

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Alpha tryptase: Potential roles in inflammation distinct from those of b-tryptase

, 2010
RATIONALE: Tryptases are among the most abundant products of the humanmast cell. Beta-tryptase has emerged as an important mediator of allergicinflammation.
Khedr, M.E.M.S., Holloway, John, Abdelmotelb, Ahmed, Pender, Sylvia, Walls, Andrew, Sommerhoff, Christian P., Zhou, Xiaoying, A.M. Abdelmotelb, C.P. Sommerhoff, S.L.F. Pender, A.F. Walls, X. Zhou, J.W. Holloway, M.E. Khedr   +13 more
core   +1 more source

Chronic Pruritic Papular Eruption in an Elderly Man

JEADV Clinical Practice, EarlyView.
Filipe Monteiro, Inês Tribolet‐Abreu, Gustavo Almeida‐Silva, Inês Amaral, Ivânia Soares, Sónia Fernandes, Joana Antunes   +6 more
wiley   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

Single‐Cell Profiling Links T‐Cell Accumulation and TH2/TH17 Dynamics to Eosinophilic Esophagitis (EoE) Activity in Children

Allergy, EarlyView.
Active EoE is associated with more and deeper epithelial eosinophil, mast cell, and T cell infiltration; inactive EoE resembles controls. During remission, PPI treatment leaves more tissue resident CD3+ T‐cells than TS. In active EoE, TH2 cells, IL‐10hi Tregs, and CD8+ cytotoxic T cells are enriched, while TH17 cells are relatively depleted.
Hannes Hoelz, Matthias Tobias Warkotsch, Simon Buehler, Tim Faro, Sabrina Wagner, Valeriia Andrieieva, Alisia Beckmann, Anja Jurk, Marie‐Luise Frank, Guido Piontek, Kolja Siebert, Sebastian Jarosch, Sibylle Koletzko, Helga Paula Török, Christoph Walz, Martina Rudelius, Katja Steiger, Dirk Busch, Tobias Schwerd   +18 more
wiley   +1 more source

rmMCP-7 is more effective in inducing tube formation by endothelial cells in vitro.

, 2015
SVEC4-10 cells were cultured for 5 hours at 37°C on Geltrex® in the presence of rmMCP-6, rmMCP-7 or in the absence of tryptases. The area covered by tubes, the tube length, number of tubes, loops and branching points, the average area occupied by the ...
Maria Célia Jamur (79424), Devandir Antonio de Souza Junior (833396), Constance Oliver (35853), Antonio Carlos Borges (833397), Ana Carolina Santana (833398)   +4 more
core   +1 more source

Diagnostic Delay in Eosinophilic Granulomatosis With Polyangiitis: Clinical Predictors and Implications for Earlier Recognition

Allergy, EarlyView.
This study aimed to assess diagnostic delay among patients with eosinophilic granulomatosis with polyangiitis (EGPA) and identify clinical characteristics associated with delayed recognition. EGPA diagnosis was delayed by nearly five years from symptom onset in this single‐center cohort.
Vani Mulkareddy, Kalena Liu, Shreya Mandloi, Kelsey Limage, Samuel R. Shing, Gurston G. Nyquist, Jessica Most, David Kennedy, Elina Toskala, Damaris Pena‐Evertz   +9 more
wiley   +1 more source