Results 41 to 50 of about 1,553 (208)

Asthma: From Phenotypes to Endotypes—Beyond Type 2 Inflammation

Respirology, EarlyView.
ABSTRACT Asthma is a heterogeneous syndrome featuring variable pathophysiology, clinical presentation and treatment response. This review examines a comprehensive endotype‐phenotype framework for asthma assessment with an emphasis on characteristics beyond T2 inflammatory status alone.
Mario Fernando, Gregory G. King
wiley   +1 more source

Safety of Venom Immunotherapy in Pregnancy: A Multicentre Study

Allergy, EarlyView.
Venom immunotherapy (VIT) during pregnancy, when maintenance dose is well tolerated, can be continued. No increased risk of adverse effects to VIT or safety concerns for the pregnancy or the newborns were observed. No decreased efficacy of VIT, in case of re‐stings, was reported.
Matteo Martini, Giovanna Sfriso, Valerio Pravettoni, Marina Mauro, Donatella Preziosi, Francesca Vettorato, Giuseppe Lucchini, Mauro Pagani, Iuliana Badiu, Maria Pia Dolcher, Francesco Gaeta, Pietro Galati, Elisa Meucci, Elide Pastorello, Vincenzo Patella, Stefano Pucci, Chiara Roncallo, Eleonora Savi, Livio Simioni, Maria Beatrice Bilò, Patrizia Bonadonna   +20 more
wiley   +1 more source

Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens

, 2013
Mouse mast cell protease (mMCP)-6-null C57BL/6 mice lost less aggrecan proteoglycan from the extracellular matrix of their articular cartilage during inflammatory arthritis than wild-type (WT) C57BL/6 mice, suggesting that this mast cell (MC)-specific ...
Adachi, R, Fosang, AJ, Magarinos, NJ, Stevens, RL, Bryant, KJ, McNeil, HP   +5 more
core   +1 more source

Determinants of Poor Health‐Related Quality of Life in Patients With Food Allergy

Allergy, EarlyView.
Machine‐learning analysis of 502 well‐characterised food‐allergic patients was used to identify key determinants of poor FA‐HRQL, defined as FAQLQ ≥ 5. The most relevant predictors were adult age, female sex, multiple food allergies, severe reactions, need for urgent care, onset before 18 years, and longer disease duration.
Rosialzira Natasha Vera‐Berrios, Alejandro Gonzalo‐Fernández, Natalia Freundt‐Serpa, Guadalupe Marco‐Martín, Beatriz Fernández‐Parra, María Isabel Alvarado‐Izquierdo, Rocío Casas‐Saucedo, Cristina Stein‐Coronado, Ethel Ibáñez‐Echevarría, Tania Ramos‐García, María Dolores Alonso‐Díaz de Durana, Azahara López‐Raigada, Carlos Blanco‐Guerra, María Pía de Calzada‐Bustingorri, Teresa Carrillo‐Díaz, Hilda Rianec Hernández‐Suárez, Miguel Ángel Díaz‐Palacios, Sonsoles Infante‐Herrero, Ana María Nieto‐Nieto, Sonia Vázquez‐Cortés, Eloína González‐Mancebo, María M. Escribese, Pilar Rico‐Nieto, Domingo Barber, Montserrat Fernández‐Rivas   +24 more
wiley   +1 more source

High degree of conservation of the multigene tryptase locus over the past 150–200 million years of mammalian evolution

, 2010
Activated mast cells release a number of potent inflammatory mediators including histamine, proteoglycans, cytokines, and serine proteases. The proteases constitute the majority of the mast cell granule proteins, and they belong to either the chymase or ...
Paul B. Samollow, Reimer, Jenny,, Jenny M. Reimer, Lars Hellman, Hellman, Lars,, Samollow, Paul   +5 more
core   +1 more source

Heritable risk for severe anaphylaxis associated with increased α-tryptase–encoding germline copy number at TPSAB1

, 2020
Background: An elevated basal serum tryptase level is associated with severe systemic anaphylaxis, most notably caused by Hymenoptera envenomation. Although clonal mast cell disease is the culprit in some individuals, it does not fully explain this ...
Le, Quang T., DiMaggio, Tom, Rijavec, Matija, Kim, Jiwon, Bai, Yun, Korošec, Peter, Chovanec, Jack, Zanotti, Roberta, Šelb, Julij, Lyons, Jonathan J., Liu, Yihui, O\u27Connell, Michael P., Hirsh D. Komarow, Jonathan J. Lyons, Patrizia Bonadonna, Lawrence B. Schwartz, Yihui Liu, Dean D. Metcalfe, Michael P. O’Connell, Matija Rijavec, Jack Chovanec, Jiwon Kim, Melody C. Carter, Quang T. Le, Roberta Zanotti, Julij Šelb, Yun Bai, Peter Korošec, Tom DiMaggio, Joshua D. Milner   +29 more
core   +1 more source

Mast cells in oral lichen planus and oral lichenoid lesions related to dental amalgam contact

Brazilian Oral Research
The aim of this study was to analyze the expression of mast cell markers toluidine blue, c-kit, and tryptase and presence of mononuclear inflammatory cells in oral lichen planus (OLP) and oral lichenoid lesions related to dental amalgam.
Mariana Saturnino de NORONHA, Giovanna Ribeiro SOUTO, Fernanda Aragão FELIX, Lucas Guimarães ABREU, Maria Cássia Ferreira AGUIAR, Elismauro Francisco MENDONÇA, Ricardo Alves MESQUITA   +6 more
doaj   +1 more source

Time‐Resolved Multi‐Omics Identify Biomarkers of Immediate Reactions to mRNA Vaccination

Allergy, EarlyView.
We compared early vaccine‐induced immune and metabolic signatures and downstream immunity after second and booster BNT162b2 doses in participants with sARs, ISSRs, or no reactions. Neutrophil mobilization, antiviral programs, and robust anti‐S‐antibody responses occurred across reaction groups.
Ana Olivera, Benjamin Schwarz, Brittany Dulek, Ian S. LaCroix, Min Li, Lindsay Chatman, Muhammad B. Khalid, Ellen Zektser, Karen Laky, Stella Hartono, Eric Bohrnsen, Cole D. Kimzey, Eric Chu, Roa Harb, Pamela A. Frischmeyer‐Guerrerio   +14 more
wiley   +1 more source

Tryptase Is Not Cleared by the Kidneys into the Urine [PDF]

International Archives of Allergy and Immunology, 2009
<i>Background:</i> Patients with chronic kidney disease have been reported to have increased concentrations of blood tryptase. Detection of tryptase in the urine of healthy subjects has been reported. <i>Objective:</i> The objective is to determine whether tryptase is indeed cleared by the kidneys.
Michael R, Simon, Mindy, Jan, Jerry, Yee, Uday S, Nori, Jiang, Hu, Cem, Akin, Lawrence B, Schwartz   +6 more
openaire   +2 more sources

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source