Results 21 to 30 of about 1,553 (208)

Mast cell tryptase and asthma [PDF]

Mediators of Inflammation, 1997
Recent physiological and pharmacological studies have indicated the potential importance of tryptase, the major protein component in mast cells, in inflammatory diseases (especially asthma). Being released at inflammatory sites after the activation of mast cells, tryptase is capable of causing bronchohyperresponsiveness and infiltration of eosinophils,
Zhang, M.Q., Timmerman, H.
openaire   +4 more sources

Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome

Gut and Liver, 2016
Background/AimsPrevious studies have revealed that mast cells (MCs) may activate the protease-activated receptors and release of neuropeptides involved in the pathogenesis of irritable bowel syndrome (IBS).
doaj   +1 more source

Tracing the Origins of IgE, Mast Cells, and Allergies by Studies of Wild Animals

Frontiers in Immunology, 2017
In most industrialized countries, allergies have increased in frequency quite dramatically during the past 50 years. Estimates show that 20–30% of the populations are affected.
Lars Torkel Hellman, Srinivas Akula, Michael Thorpe, Zhirong Fu   +3 more
doaj   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

In the presence of rmMCP-6 and rmMCP-7 the endothelial cells invade the Geltrex^®.

, 2015
SVEC4-10 cells were cultured for 5 hours at 37°C on Geltrex® in the presence of rmMCP-6, rmMCP-7 or in the absence of tryptases. In the absence of rmMCP-6 or -7, most of the SVEC4-10 cells remained rounded (arrows) and few cells spread on the substrate ...
Maria Célia Jamur (79424), Devandir Antonio de Souza Junior (833396), Constance Oliver (35853), Antonio Carlos Borges (833397), Ana Carolina Santana (833398)   +4 more
core   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Bovine tryptases. cDNA cloning, tissue specific expression and characterization of the lung isoform

, 2003
A complementary DNA encoding a new bovine tryptase isoform (here named BLT) was cloned and sequenced from lung tissue. Analysis of sequence indicates the presence of a 26-amino acid prepro-sequence and a 245 amino acid catalytic domain.
Amoresano, Angela, Basili, Paolo, Erba, Fulvio, Fiorucci, Laura, Gambacurta, Alessandra, Ascoli, Franca   +5 more
core   +1 more source

Coexistence of immunophenotypically normal and aberrant mast cells in patients with clonal mast cell diseases associates with more indolent subtypes and less severe disease characteristics

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Aberrant antigen expression on mast cells (MCs) is one of the most accurate diagnostic markers for clonal MC diseases (CMCD). Although the coexistence of normal and pathologic MCs is frequently seen, the disease characteristics associated with it have been minimally investigated.
Abdulrazzaq Alheraky, Kees Meijer, Marije Nijk, Saskia K. Klein, Hanneke N. G. Oude Elberink, Ido P. Kema, André B. Mulder   +6 more
wiley   +1 more source

The expression and activity of metalloprotease or gel compound of are not altered in the presence of mast cell tryptases.

, 2015
The cells were cultured for 5 hours at 37°C on Geltrex® in the presence of rmMCP-6, rmMCP-7 or in the absence of tryptases. After incubation, the culture supernatants were used for immunoblotting to analyze metalloprotease expression and for zymograms to
Maria Célia Jamur (79424), Devandir Antonio de Souza Junior (833396), Constance Oliver (35853), Antonio Carlos Borges (833397), Ana Carolina Santana (833398)   +4 more
core   +1 more source

World Allergy Organization survey on the diagnosis and management trends of perioperative anaphylaxis

World Allergy Organization Journal
Background: Perioperative anaphylaxis (POA) is a life-threatening condition with substantial variability in evaluation and management practices. Objective: To assess current practices, perceived barriers, and regional differences in POA management among ...
Alexei Gonzalez-Estrada, MD, Ricardo J. Estrada-Mendizabal, MD, Ignacio J. Ansotegui, MD, PhD, Dianne E. Campbell, MD, PhD, Stuart Carr, MD, PhD, Victoria Cardona, MD, PhD, Motohiro Ebisawa, MD, PhD, Mario Geller, MD, Margitta Worm, MD, PhD, Paul A. Greenberger, MD, PhD, Agnes S.Y. Leung, MD, PhD, Michael E. Levin, MD, PhD, Mario Morais-Almeida, MD, PhD, Antonella Muraro, MD, PhD, Jose A. Ortega-Martell, MD, PhD, Guillaume Pouessel, MD, Gianenrico Senna, MD, PhD, Paul J. Turner, MD, PhD, Luciana Kase Tanno, MD, PhD   +18 more
doaj   +1 more source