Results 61 to 70 of about 1,553 (208)
Mast cell proteases as pharmacological targets [PDF]
, 2016 Mast cells are rich in proteases, which are the major proteins of intracellular granules and are released with histamine and heparin by activated cells.
George H. Caughey, Caughey, George H
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The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis
Allergy, EarlyView.ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith +9 more
wiley +1 more source
Andrology, EarlyView.ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam +7 more
wiley +1 more source
Fibrinogenolysis by Human Lung Mast Cell Tryptase
, 1996 Tryptases are 31 kDa, glycosylated, trypsin-like enzymes that are stored in and released from mast cell granules. Tryptases exist as tetramers and bind heparin, which stabilizes their activity, but they are not inhibited by blood plasma proteinase ...
Carpenter, Marcus D. +2 more
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Alimentary Pharmacology &Therapeutics, EarlyView.A large data base of colonoscopies was analysed for mast cells. The data do not show a relationship between diarrhoea and elevated mast cells in the colonic mucosa. This study provides real‐world evidence against the routine diagnostic use of colonic mast cell quantification for the evaluation of diarrhoea.
Marlena Langreiter +2 more
wiley +1 more source
The fight of innate immunity and abnormal cannabinoids against Candida infection
British Journal of Pharmacology, EarlyView.Candida species represent the most clinically significant fungal pathogens in humans, with invasive candidiasis carrying a mortality of 30%–40% in critically ill patients despite modern antifungal therapy. The innate immune system – through the coordinated and specific activities of neutrophils, macrophages, NK cells, mast cells and eosinophils ...
Prince Ofori +2 more
wiley +1 more source
, 2001 Background Sudden Infant Death Syndrome, (SIDS) or cot death, remains the most common category of post-perinatal death in the UK. By definition, the cause of death is unknown, but a long-standing theory is that some of these deaths could be the result ...
A. F. Walls +5 more
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Mouse Mast Cell Proteases: Induction, Molecular Cloning, and Characterization [PDF]
, 1991 Tryptase, a mast cell-specific serine protease with trypsin-like specificity, has been identified in a mouse mast cell line (ABFTL-6) based on it\u27s enzymatic activity, inhibition properties, and cross-reactivity to a human mast cell tryptase antibody.
Chu, Wei
core +1 more source
, 2002 Human mast cell tryptases represent a subfamily of trypsin-like serine proteinases implicated in asthma. Unlike beta-tryptases, alpha-tryptases apparently are proteolytically inactive.
Bode, W. +4 more
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