Results 1 to 10 of about 1,400,417 (341)
Immune regulation through tryptophan metabolism
Experimental and Molecular Medicine, 2023 Amino acids are fundamental units of molecular components that are essential for sustaining life; however, their metabolism is closely interconnected to the control systems of cell function.
Su-Kil Seo, Byungsuk Kwon
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Tryptophan metabolism is a physiological integrator regulating circadian rhythms
Molecular Metabolism, 2022 Objective: The circadian clock aligns physiology with the 24-hour rotation of Earth. Light and food are the main environmental cues (zeitgebers) regulating circadian rhythms in mammals.
Paul Petrus +17 more
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Dietary fibre directs microbial tryptophan metabolism via metabolic interactions in the gut microbiota [PDF]
Nature MicrobiologyTryptophan is catabolized by gut microorganisms resulting in a wide range of metabolites implicated in both beneficial and adverse host effects. How gut microbial tryptophan metabolism is directed towards indole, associated with chronic kidney disease ...
Anurag Kumar Sinha +8 more
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Metabolites, 2023 Tryptophan metabolism and gut microbiota form an integrated regulatory axis that impacts immunity, metabolism, and cancer. This review consolidated current knowledge on the bidirectional interactions between microbial tryptophan processing and the host ...
Yingjian Hou, Jing Li, Shuhuan Ying
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Tryptophan metabolism: Mechanism-oriented therapy for neurological and psychiatric disorders
Frontiers in Immunology, 2022 Neurological and psychiatric disorders are a category of chronic diseases that are widespread and pose serious mental and physical health problems for patients.
Dan Li +12 more
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Deciphering tryptophan metabolism in colorectal cancer through multi-omics analysis [PDF]
Biochemistry and Biophysics ReportsMetabolic reprogramming is essential for colorectal cancer (CRC) progression, and recent studies have pointed to tryptophan metabolism as a crucial modulator of the tumor immune microenvironment.
Chengcheng Zhang +14 more
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Frontiers in Cellular and Infection Microbiology, 2023 BackgroundsGut microbiota plays a critical role in the onset and development of depression, but the underlying molecular mechanisms are unclear. This study was conducted to explore the relationships between gut microbiota and host’s metabolism in ...
Jing Xie +8 more
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Tryptophan metabolism as a target in gut microbiota, ageing and kidney disease. [PDF]
Int J Biol SciAromatic amino acid tryptophan metabolism, particularly three main metabolism pathways including kynurenine, serotonin and indole-derived pathways are under the direct or indirect modulation of host-microbiota crosstalk in human physiology.
Miao H, Zhang SJ, Wu X, Li P, Zhao YY.
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Tryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico Analysis [PDF]
Frontiers in Neuroscience, 2019 The link between gut microbiome and brain is being slowly acknowledged due to the speculated role of resident gut microbial community in altering the functions of gut-brain axis (GBA).
Harrisham Kaur +2 more
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Interactions between gut microbiota and parkinson’s disease: the role of tryptophan metabolism [PDF]
Cell Communication and SignalingParkinson’s disease, a common neurodegenerative disorder in the elderly, is characterized by motor symptoms and non-motor symptoms such as anxiety, depression, sleep disturbances, and gastrointestinal dysfunction, highlighting its nature as a multisystem
Xuemei Fan +6 more
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