Results 1 to 10 of about 99,502 (307)

Deciphering tryptophan metabolism in colorectal cancer through multi-omics analysis [PDF]

Biochemistry and Biophysics Reports
Metabolic reprogramming is essential for colorectal cancer (CRC) progression, and recent studies have pointed to tryptophan metabolism as a crucial modulator of the tumor immune microenvironment.
Chengcheng Zhang, Zhijing Rao, Xiangyang Zhan, Jingru Qin, Lu Yang, Qianqian Yin, Junqing Ji, Xiaoxue Zhao, Yiyi Liu, Zhanhui Lu, Guoying Wang, Xingshuai Huang, Wenbo Shi, Wan Su, Zhongqi Wang   +14 more
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Toll-like Receptor Activation Remodels the Polyamine and Tryptophan Metabolism in Porcine Macrophages [PDF]

Metabolites
Background: The early nutritional metabolism of piglets is intimately associated with the regulation of immune function, and amino acids play a crucial role in modulating the fate and function of porcine immune cells, especially macrophages. However, the
Meimei Zhang, Lingfei Du, Yinhao Shen, Peng Bin   +3 more
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Aberrant Tryptophan Metabolism Manipulates Osteochondral Homeostasis [PDF]

Research
Tryptophan (Trp), an essential amino acid, performs as a precursor for synthesizing various bioactive molecules primarily metabolized through the kynurenine (Kyn), serotonin, and indole pathways. The diverse metabolites were deeply implicated in multiple
Tingwen Xiang, Chuan Yang, Langlang Xie, Shiyu Xiao, Yong Tang, Gang Huang, Dong Sun, Yueqi Chen, Fei Luo   +8 more
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Integrating single-cell RNA-Seq and machine learning to dissect tryptophan metabolism in ulcerative colitis [PDF]

Journal of Translational Medicine
Background Ulcerative colitis (UC) is a persistent inflammatory bowels disease (IBD) characterized by immune response dysregulation and metabolic disruptions.
Guorong Chen, Hongying Qi, Li Jiang, Shijie Sun, Junhai Zhang, Jiali Yu, Fang Liu, Yanli Zhang, Shiyu Du   +8 more
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Identification of tryptophan metabolism-related biomarkers for nonalcoholic fatty liver disease through network analysis [PDF]

Endocrine Connections
Background: Increasing evidence demonstrates that tryptophan metabolism is closely related to the development of nonalcoholic fatty liver disease (NAFLD). This study aimed to identify specific biomarkers of NAFLD associated with tryptophan metabolism and
Cuihua Jiang, Jianqi Liang, Kaibo Hu, Yanqing Ye, Jiajia Yang, Xiaozhi Zhang, Guilin Ye, Jing Zhang, Deju Zhang, Bin Zhong, Peng Yu, Liefeng Wang, Bin Zeng   +12 more
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Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs

Animal Nutrition, 2022
Intestinal microbes are closely associated with host health, depending on metabolic crosstalk between the microbiota and host. Tryptophan metabolism is one of the best examples of metabolic crosstalk between intestinal microbiota and host; however, our ...
Bingnan Liu, Dongming Yu, Jing Sun, Xiaoyan Wu, Zhongquan Xin, Baichuan Deng, Lijuan Fan, Jian Fu, Liangpeng Ge, Wenkai Ren   +9 more
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Tryptophan metabolism is a physiological integrator regulating circadian rhythms

Molecular Metabolism, 2022
Objective: The circadian clock aligns physiology with the 24-hour rotation of Earth. Light and food are the main environmental cues (zeitgebers) regulating circadian rhythms in mammals.
Paul Petrus, Marlene Cervantes, Muntaha Samad, Tomoki Sato, Alina Chao, Shogo Sato, Kevin B. Koronowski, Grace Park, Yasmine Alam, Niklas Mejhert, Marcus M. Seldin, José Manuel Monroy Kuhn, Kenneth A. Dyar, Dominik Lutter, Pierre Baldi, Peter Kaiser, Cholsoon Jang, Paolo Sassone-Corsi   +17 more
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TrpNet: Understanding Tryptophan Metabolism across Gut Microbiome

Metabolites, 2021
Crosstalk between the gut microbiome and the host plays an important role in animal development and health. Small compounds are key mediators in this host–gut microbiome dialogue.
Yao Lu, Jasmine Chong, Shiqian Shen, Joey-Bahige Chammas, Lorraine Chalifour, Jianguo Xia   +5 more
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Tryptophan metabolism: Mechanism-oriented therapy for neurological and psychiatric disorders

Frontiers in Immunology, 2022
Neurological and psychiatric disorders are a category of chronic diseases that are widespread and pose serious mental and physical health problems for patients.
Dan Li, Shuang Yu, Yu Long, Ai Shi, Jie Deng, Yin Ma, Jing Wen, Xiaoqiu Li, Songyu Liu, Yulu Zhang, Jinyan Wan, Nan Li, Rui Ao   +12 more
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Metabonomic Study of the Involvement of the Intestinal Microflora in the Improvement of Iron Deficiency Anemia (IDA) by Auricularia auricula Melanin in Mice [PDF]

Shipin Kexue, 2023
Iron deficiency anemia (IDA) is a common iron deficiency disease. IDA has become one of the major public health problems worldwide. Our previous studies have shown that Auricularia auricula melanin (AAM) can alleviate IDA, but the mechanism is not clear.
WANG Yuting, LI Yuanjing, CHU Fuying, SHI Shuliang, LEI Hong, FENG Lei
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