Results 11 to 20 of about 1,400,417 (341)

Integrating single-cell RNA-Seq and machine learning to dissect tryptophan metabolism in ulcerative colitis

Journal of Translational Medicine
Background Ulcerative colitis (UC) is a persistent inflammatory bowels disease (IBD) characterized by immune response dysregulation and metabolic disruptions.
Guorong Chen, Hongying Qi, Li Jiang, Shijie Sun, Junhai Zhang, Jiali Yu, Fang Liu, Yanli Zhang, Shiyu Du   +8 more
doaj   +2 more sources

The Engagement of Cytochrome P450 Enzymes in Tryptophan Metabolism

Metabolites, 2023
Tryptophan is metabolized along three main metabolic pathways, namely the kynurenine, serotonin and indole pathways. The majority of tryptophan is transformed via the kynurenine pathway, catalyzed by tryptophan-2,3-dioxygenase or indoleamine-2,3 ...
Anna Haduch, Ewa Bromek, Wojciech Kuban, Władysława Anna Daniel   +3 more
doaj   +2 more sources

Seasonal Plasticity in Tryptophan Metabolism Provides New Insights Into Physiological Adaptation in Snake Hibernation [PDF]

Ecology and Evolution
Hibernation is a common behavioral strategy for snakes to cope with extreme environments. This phenomenon has raised important scientific questions regarding its physiological adaptation mechanisms. Although tryptophan and its metabolites have been widel
Yuting Wei, Zexiu Zhang, Xiaohong Lin, Gangning Wei, Pengyue Zhang, Huirong Mao, Biao Chen, Jianhao Ji, Yunlin Zheng, Zhiyi Luo, Xiaolong Hu   +10 more
doaj   +2 more sources

The Kynurenine Pathway and Indole Pathway in Tryptophan Metabolism Influence Tumor Progression. [PDF]

Cancer Med
Tryptophan (Trp), an essential amino acid, is solely acquired through dietary intake. It is vital for protein biosynthesis and acts as a precursor for numerous key bioactive compounds.
Lu Z, Zhang C, Zhang J, Su W, Wang G, Wang Z.   +5 more
europepmc   +2 more sources

Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis

Gut Microbes, 2022
Gut microbial disturbance affects allergic diseases including asthma, atopic dermatitis (AD) via the aberrant immune response. Some Bifidobacterial species and strains have been reported to improve AD via modulating immune-microbe interactions in ...
Zhifeng Fang, Tong Pan, Lingzhi Li, Hongchao Wang, Jinlin Zhu, Hao Zhang, Jianxin Zhao, Wei Chen, Wenwei Lu   +8 more
doaj   +2 more sources

New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis

Frontiers in Immunology
Arginine and tryptophan are pivotal in orchestrating cytokine-driven macrophage polarization and immune activation. Specifically, interferon-gamma (IFN-γ) stimulates inducible nitric oxide synthase (iNOS) expression), leading to the conversion of ...
Kangling Zhang, Abhishek Mishra, Chinnaswamy Jagannath   +2 more
doaj   +2 more sources

Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies

Gut, 2021
Objective Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites with incident type 2 diabetes (T2D), host genetics, diet ...
Qibin Qi, Jun Li, Bing Yu, Jee‐Young Moon, Jin Choul Chai, Jordi Merino, Jie Hu, Miguel Ruiz‐Canela, Casey M. Rebholz, Zheng Wang, Mykhaylo Usyk, Guo‐Chong Chen, Bianca Porneala, Wenshuang Wang, Ngoc Quynh Nguyen, Elena V. Feofanova, Megan L. Grove, Thomas J. Wang, Robert E. Gerszten, Josée Dupuis, Jordi Salas‐Salvadó, Wei Bao, David L. Perkins, Martha L. Daviglus, Bharat Thyagarajan, Jianwen Cai, Tao Wang, JoAnn E. Manson, Miguel Ángel Martínez‐González, Elizabeth Selvin, Kathryn M. Rexrode, Clary B. Clish, Frank B. Hu, James B. Meigs, Rob Knight, Robert D. Burk, Eric Boerwinkle, Robert C. Kaplan   +37 more
openalex   +3 more sources

The microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut

Cell Reports
Summary: Chronic stress disrupts microbiota-gut-brain axis function and is associated with altered tryptophan metabolism, impaired gut barrier function, and disrupted diurnal rhythms.
Cassandra E. Gheorghe, Sarah-Jane Leigh, Gabriel S.S. Tofani, Thomaz F.S. Bastiaanssen, Joshua M. Lyte, Elisa Gardellin, Ashokkumar Govindan, Conall Strain, Sonia Martinez-Herrero, Michael S. Goodson, Nancy Kelley-Loughnane, John F. Cryan, Gerard Clarke   +12 more
doaj   +2 more sources

Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs

Animal Nutrition, 2022
Intestinal microbes are closely associated with host health, depending on metabolic crosstalk between the microbiota and host. Tryptophan metabolism is one of the best examples of metabolic crosstalk between intestinal microbiota and host; however, our ...
Bingnan Liu, Dongming Yu, Jing Sun, Xiaoyan Wu, Zhongquan Xin, Baichuan Deng, Lijuan Fan, Jian Fu, Liangpeng Ge, Wenkai Ren   +9 more
doaj   +1 more source

Promising Gastric Cancer Biomarkers-Focus on Tryptophan Metabolism via the Kynurenine Pathway. [PDF]

Int J Mol Sci
Ożga K, Stepuch P, Maciejewski R, Sadok I.   +3 more
europepmc   +3 more sources