Toll-like Receptor Activation Remodels the Polyamine and Tryptophan Metabolism in Porcine Macrophages [PDF]
MetabolitesBackground: The early nutritional metabolism of piglets is intimately associated with the regulation of immune function, and amino acids play a crucial role in modulating the fate and function of porcine immune cells, especially macrophages. However, the
Meimei Zhang +3 more
doaj +2 more sources
New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis
Frontiers in ImmunologyArginine and tryptophan are pivotal in orchestrating cytokine-driven macrophage polarization and immune activation. Specifically, interferon-gamma (IFN-γ) stimulates inducible nitric oxide synthase (iNOS) expression), leading to the conversion of ...
Kangling Zhang +2 more
doaj +2 more sources
Aberrant Tryptophan Metabolism Manipulates Osteochondral Homeostasis [PDF]
ResearchTryptophan (Trp), an essential amino acid, performs as a precursor for synthesizing various bioactive molecules primarily metabolized through the kynurenine (Kyn), serotonin, and indole pathways. The diverse metabolites were deeply implicated in multiple
Tingwen Xiang +8 more
doaj +2 more sources
Integrating single-cell RNA-Seq and machine learning to dissect tryptophan metabolism in ulcerative colitis [PDF]
Journal of Translational MedicineBackground Ulcerative colitis (UC) is a persistent inflammatory bowels disease (IBD) characterized by immune response dysregulation and metabolic disruptions.
Guorong Chen +8 more
doaj +2 more sources
Identification of tryptophan metabolism-related biomarkers for nonalcoholic fatty liver disease through network analysis [PDF]
Endocrine ConnectionsBackground: Increasing evidence demonstrates that tryptophan metabolism is closely related to the development of nonalcoholic fatty liver disease (NAFLD). This study aimed to identify specific biomarkers of NAFLD associated with tryptophan metabolism and
Cuihua Jiang +12 more
doaj +2 more sources
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
Nature Reviews Drug Discovery, 2019 Michael Platten +2 more
exaly +2 more sources
Tryptophan Metabolism as a Pharmacological Target [PDF]
Trends in Pharmacological Sciences, 2021 L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many bioactive molecules acting in various organs through different action mechanisms.
Morgane Modoux +4 more
openaire +4 more sources
TrpNet: Understanding Tryptophan Metabolism across Gut Microbiome
Metabolites, 2021 Crosstalk between the gut microbiome and the host plays an important role in animal development and health. Small compounds are key mediators in this host–gut microbiome dialogue.
Yao Lu +5 more
doaj +1 more source
Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth
Advancement of science, 2023 Emerging evidence reveals that amino acid metabolism plays an important role in ferroptotic cell death. The conversion of methionine to cysteine is well known to protect tumour cells from ferroptosis upon cysteine starvation through transamination ...
Dong Liu +15 more
semanticscholar +1 more source
Aging and Disease, 2023 The metabolism of L-tryptophan (TRP) regulates homeostasis, immunity, and neuronal function. Altered TRP metabolism has been implicated in the pathophysiology of various diseases of the central nervous system. TRP is metabolized through two main pathways,
Yinrou Huang +12 more
semanticscholar +1 more source