Results 11 to 20 of about 1,375,182 (353)
Tryptophan metabolism in alcoholism [PDF]
Nutrition Research Reviews, 2002 Studies of tryptophan (Trp) metabolism in relation to the serotonin status in alcoholism are of 2 types: (1) those related to the pharmacological effects of ethanol; (2) those concerning the serotonin status in the absence of alcohol intake. In experimental animals, acute and chronic ethanol administration and subsequent withdrawal exert a variety of ...
Abdulla A.‐B. Badawy
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Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer. [PDF]
Mol CancerTryptophan (Trp) metabolism involves three primary pathways: the kynurenine (Kyn) pathway (KP), the 5-hydroxytryptamine (serotonin, 5-HT) pathway, and the indole pathway.
Yan J +11 more
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Gut Microbes, 2022 Gut microbial disturbance affects allergic diseases including asthma, atopic dermatitis (AD) via the aberrant immune response. Some Bifidobacterial species and strains have been reported to improve AD via modulating immune-microbe interactions in ...
Zhifeng Fang +8 more
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Toll-like Receptor Activation Remodels the Polyamine and Tryptophan Metabolism in Porcine Macrophages [PDF]
MetabolitesBackground: The early nutritional metabolism of piglets is intimately associated with the regulation of immune function, and amino acids play a crucial role in modulating the fate and function of porcine immune cells, especially macrophages. However, the
Meimei Zhang +3 more
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New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis
Frontiers in ImmunologyArginine and tryptophan are pivotal in orchestrating cytokine-driven macrophage polarization and immune activation. Specifically, interferon-gamma (IFN-γ) stimulates inducible nitric oxide synthase (iNOS) expression), leading to the conversion of ...
Kangling Zhang +2 more
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Tryptophan Metabolism as a Pharmacological Target [PDF]
Trends in Pharmacological Sciences, 2021 L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many bioactive molecules acting in various organs through different action mechanisms.
Morgane Modoux +4 more
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Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs
Animal Nutrition, 2022 Intestinal microbes are closely associated with host health, depending on metabolic crosstalk between the microbiota and host. Tryptophan metabolism is one of the best examples of metabolic crosstalk between intestinal microbiota and host; however, our ...
Bingnan Liu +9 more
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Tryptophan metabolism is a physiological integrator regulating circadian rhythms
Molecular Metabolism, 2022 Objective: The circadian clock aligns physiology with the 24-hour rotation of Earth. Light and food are the main environmental cues (zeitgebers) regulating circadian rhythms in mammals.
Paul Petrus +17 more
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TrpNet: Understanding Tryptophan Metabolism across Gut Microbiome
Metabolites, 2021 Crosstalk between the gut microbiome and the host plays an important role in animal development and health. Small compounds are key mediators in this host–gut microbiome dialogue.
Yao Lu +5 more
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Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth
Advancement of science, 2023 Emerging evidence reveals that amino acid metabolism plays an important role in ferroptotic cell death. The conversion of methionine to cysteine is well known to protect tumour cells from ferroptosis upon cysteine starvation through transamination ...
Dong Liu +15 more
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