Results 21 to 30 of about 1,375,182 (353)
Metabonomic Study of the Involvement of the Intestinal Microflora in the Improvement of Iron Deficiency Anemia (IDA) by Auricularia auricula Melanin in Mice [PDF]
Shipin Kexue, 2023 Iron deficiency anemia (IDA) is a common iron deficiency disease. IDA has become one of the major public health problems worldwide. Our previous studies have shown that Auricularia auricula melanin (AAM) can alleviate IDA, but the mechanism is not clear.
WANG Yuting, LI Yuanjing, CHU Fuying, SHI Shuliang, LEI Hong, FENG Lei
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Aging and Disease, 2023 The metabolism of L-tryptophan (TRP) regulates homeostasis, immunity, and neuronal function. Altered TRP metabolism has been implicated in the pathophysiology of various diseases of the central nervous system. TRP is metabolized through two main pathways,
Yinrou Huang +12 more
semanticscholar +1 more source
Tryptophan metabolism in depression [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1970 Psychiatric patients suffering from endogenous depression and a control group without endogenous depression were given oral loads of L-tryptophan and urinary excretion determined of the tryptophan metabolites on the pyrrolase pathway: kynurenine, 3-hydroxykynurenine, and 3-hydroxyanthranilic acid.
P. K. Bridges, G. Curzon
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The Role of Tryptophan Metabolism in Alzheimer’s Disease
Brain Science, 2023 The need to identify new potentially druggable biochemical mechanisms for Alzheimer’s disease (AD) is an ongoing priority. The therapeutic limitations of amyloid-based approaches are further motivating this search.
Karl Savonije, D. Weaver
semanticscholar +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Tryptophan is metabolized by microorganisms into various indole derivatives that have been proven to alleviate diseases and promote human health. Lactic acid bacteria (LAB) are a broad microbial concept, some of which have been developed as probiotics ...
Tong Pan +8 more
semanticscholar +1 more source
Metformin reprograms tryptophan metabolism to stimulate CD8+ T cell function in colorectal cancer.
Cancer Research, 2023 Colorectal carcinogenesis coincides with immune cell dysfunction. Metformin has been reported to play a role in stimulating anti-tumor immunity, suggesting it could be used to overcome immunosuppression in colorectal cancer (CRC).
Xiaowen Huang +12 more
semanticscholar +1 more source
Nutrients, 2023 Evidence is emerging for the role of intestinal tryptophan metabolism in the development of inflammatory bowel disease (IBD). In order to identify the role of altered intestinal tryptophan metabolism in IBD pathogenesis, a meta-analysis of the ...
Sha Wang +4 more
semanticscholar +1 more source
Tryptophan metabolism in bipolar disorder
European Psychiatry, 2022 Introduction Immune mediated inflammatory processes are involved in the aetiopathogenesis of bipolar disorder (BD) and weight associated comorbidities. Tryptophan breakdown via indoleamine 2,3-dioxygenase-1 (IDO-1) along the kynurenine axis concomitant ...
F. Fellendorf +11 more
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Nutrients, 2023 (1) Background: L-tryptophan is a substrate for the synthesis of many biological compounds through the serotonin and kynurenine pathways. These compounds have a significant influence on gastrointestinal functions and mental processes.
C. Chojnacki +5 more
semanticscholar +1 more source
Biomolecules, 2022 Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several competing pathways of tryptophan ...
Knut Hestad +3 more
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