Results 31 to 40 of about 1,400,417 (341)
Microorganisms, 2021 Akkermansia muciniphila, a potential probiotic, has been proven to lessen the effects of several diseases. As established, the relative abundance of Akkermansia is positively correlated with tryptophan metabolism.
Jia Yin +7 more
doaj +1 more source
Metformin reprograms tryptophan metabolism to stimulate CD8+ T cell function in colorectal cancer.
Cancer Research, 2023 Colorectal carcinogenesis coincides with immune cell dysfunction. Metformin has been reported to play a role in stimulating anti-tumor immunity, suggesting it could be used to overcome immunosuppression in colorectal cancer (CRC).
Xiaowen Huang +12 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2023 Introduction: The 5-year survival of gastric cancer (GC) patients with advanced stage remains poor. Some evidence has indicated that tryptophan metabolism may induce cancer progression through immunosuppressive responses and promote the malignancy of ...
Peng Luo +6 more
doaj +1 more source
Tryptophan metabolites in depression: Modulation by gut microbiota
Frontiers in Behavioral Neuroscience, 2022 Clinical depression is a multifactorial disorder and one of the leading causes of disability worldwide. The alterations in tryptophan metabolism such as changes in the levels of serotonin, kynurenine, and kynurenine acid have been implicated in the ...
Iva Lukić +3 more
doaj +1 more source
USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer
Nature Communications, 2022 Indoleamine 2,3 dioxygenase 1 (IDO1) is an attractive target for cancer immunotherapy. However, IDO1 inhibitors have shown disappointing therapeutic efficacy in clinical trials, mainly because of the activation of the aryl hydrocarbon receptor (AhR ...
Dongni Shi +17 more
semanticscholar +1 more source
The Role of Tryptophan Metabolism in Alzheimer’s Disease
Brain Science, 2023 The need to identify new potentially druggable biochemical mechanisms for Alzheimer’s disease (AD) is an ongoing priority. The therapeutic limitations of amyloid-based approaches are further motivating this search.
Karl Savonije, D. Weaver
semanticscholar +1 more source
Tryptophan metabolism in depression [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1970 Psychiatric patients suffering from endogenous depression and a control group without endogenous depression were given oral loads of L-tryptophan and urinary excretion determined of the tryptophan metabolites on the pyrrolase pathway: kynurenine, 3-hydroxykynurenine, and 3-hydroxyanthranilic acid.
G, Curzon, P K, Bridges
openaire +2 more sources
Frontiers in Cellular and Infection Microbiology, 2023 Tryptophan is metabolized by microorganisms into various indole derivatives that have been proven to alleviate diseases and promote human health. Lactic acid bacteria (LAB) are a broad microbial concept, some of which have been developed as probiotics ...
Tong Pan +8 more
semanticscholar +1 more source
Nutrients, 2023 Evidence is emerging for the role of intestinal tryptophan metabolism in the development of inflammatory bowel disease (IBD). In order to identify the role of altered intestinal tryptophan metabolism in IBD pathogenesis, a meta-analysis of the ...
Sha Wang +4 more
semanticscholar +1 more source
Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity
Microbiome, 2022 Background Dysregulation of gut microbiota-associated tryptophan metabolism has been observed in patients with multiple sclerosis. However, defining direct mechanistic links between this apparent metabolic rewiring and individual constituents of the gut ...
T. Montgomery +8 more
semanticscholar +1 more source