Results 31 to 40 of about 1,375,182 (353)
Nutritional Aspect of Tryptophan Metabolism [PDF]
International Journal of Tryptophan Research, 2013 Mammals, including humans, can synthesize the vitamin nicotinamide from tryptophan in the liver. The resultant nicotinamide is distributed to non-hepatic tissues. We have studied the effects of changes in tryptophan–nicotinamide metabolism on niacin nutritional status. The liver plays a critical role in nicotinamide supply.
Tsutomu Fukuwatari, Katsumi Shibata
openaire +3 more sources
Microorganisms, 2021 Akkermansia muciniphila, a potential probiotic, has been proven to lessen the effects of several diseases. As established, the relative abundance of Akkermansia is positively correlated with tryptophan metabolism.
Jia Yin +7 more
doaj +1 more source
Tryptophan Metabolism and Gut-Brain Homeostasis
International Journal of Molecular Sciences, 2021 Tryptophan is an essential amino acid critical for protein synthesis in humans that has emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the neurotransmitter serotonin, which is vital for the processing of emotional ...
W. Roth +4 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2023 Introduction: The 5-year survival of gastric cancer (GC) patients with advanced stage remains poor. Some evidence has indicated that tryptophan metabolism may induce cancer progression through immunosuppressive responses and promote the malignancy of ...
Peng Luo +6 more
doaj +1 more source
International Journal of Molecular Sciences, 2022 Depression is a common and serious disorder, characterized by symptoms like anhedonia, lack of energy, sad mood, low appetite, and sleep disturbances.
A. Correia, N. Vale
semanticscholar +1 more source
Tryptophan metabolites in depression: Modulation by gut microbiota
Frontiers in Behavioral Neuroscience, 2022 Clinical depression is a multifactorial disorder and one of the leading causes of disability worldwide. The alterations in tryptophan metabolism such as changes in the levels of serotonin, kynurenine, and kynurenine acid have been implicated in the ...
Iva Lukić +3 more
doaj +1 more source
Nature Communications, 2022 Honeybees are highly social insects with a rich behavioral repertoire and are a versatile model for neurobiological research. Their gut microbiota comprises a limited number of host-restricted bacterial phylotypes that are important for honeybee health ...
Zijing Zhang +5 more
semanticscholar +1 more source
USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer
Nature Communications, 2022 Indoleamine 2,3 dioxygenase 1 (IDO1) is an attractive target for cancer immunotherapy. However, IDO1 inhibitors have shown disappointing therapeutic efficacy in clinical trials, mainly because of the activation of the aryl hydrocarbon receptor (AhR ...
Dongni Shi +17 more
semanticscholar +1 more source
Gut, 2022 Objective The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is still unclear. However, several Trp metabolism end-products are essential to intestinal homeostasis.
C. Michaudel +35 more
semanticscholar +1 more source
Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity
Microbiome, 2022 Background Dysregulation of gut microbiota-associated tryptophan metabolism has been observed in patients with multiple sclerosis. However, defining direct mechanistic links between this apparent metabolic rewiring and individual constituents of the gut ...
T. Montgomery +8 more
semanticscholar +1 more source