Results 51 to 60 of about 1,375,182 (353)

Microbial Tryptophan Metabolism Tunes Host Immunity, Metabolism, and Extraintestinal Disorders

Metabolites, 2022
The trillions of commensal microorganisms comprising the gut microbiota have received growing attention owing to their impact on host physiology. Recent advances in our understandings of the host–microbiota crosstalk support a pivotal role of microbiota ...
Moyan Liu, M. Nieuwdorp, W. D. de Vos, E. Rampanelli   +3 more
semanticscholar   +1 more source

Alterations in tryptophan metabolism and de novo NAD+ biosynthesis within the microbiota-gut-brain axis in chronic intestinal inflammation

Frontiers in Medicine
BackgroundInflammatory bowel disease is an incurable and idiopathic disease characterized by recurrent gastrointestinal tract inflammation. Tryptophan metabolism in mammalian cells and some gut microbes comprise intricate chemical networks facilitated by
Jeannie Devereaux, Ainsley M. Robinson, Ainsley M. Robinson, Ainsley M. Robinson, Rhian Stavely, Rhian Stavely, Majid Davidson, Narges Dargahi, Ramya Ephraim, Dimitros Kiatos, Vasso Apostolopoulos, Vasso Apostolopoulos, Vasso Apostolopoulos, Kulmira Nurgali, Kulmira Nurgali, Kulmira Nurgali   +15 more
doaj   +1 more source

Tryptophan Metabolism Disorder-Triggered Diseases, Mechanisms, and Therapeutic Strategies: A Scientometric Review

Nutrients
Background: Tryptophan is widely present in foods such as peanuts, milk, and bananas, playing a crucial role in maintaining metabolic homeostasis in health and disease.
Xue Chen, Dong Xu, Jie Yu, Xu-Jiao Song, Xue Li, Yuanlu Cui   +5 more
semanticscholar   +1 more source

Altered Tryptophan and Neopterin Metabolism In Cancer Patients

Pteridines, 1998
Plasma 5-hydroxytryptamine (serotonin), tryptophan and neopterin levels were measured in patients with depressive cancer cachexia and in healthy controls during the same time period.
Iwagaki Hiromi, Hizuta Akio, Nitta Yasuki, Tanaka Noriaki   +3 more
doaj   +1 more source

ERRFI1 induces apoptosis of hepatocellular carcinoma cells in response to tryptophan deficiency

Cell Death Discovery, 2021
Tryptophan metabolism is an essential regulator of tumor immune evasion. However, the effect of tryptophan metabolism on cancer cells remains largely unknown.
Mingqing Cui, Dan Liu, Wujun Xiong, Yugang Wang, Jun Mi   +4 more
doaj   +1 more source

BICC1 drives pancreatic cancer stemness and chemoresistance by facilitating tryptophan metabolism

Science Advances
Pancreatic adenocarcinoma is the fourth leading cause of malignancy-related deaths, with rapid development of drug resistance driven by pancreatic cancer stem cells.
Huizhi Sun, Hui Li, Yuqi Guan, Yudong Yuan, Chao Xu, Danqi Fu, Peng Xie, Jianming Li, Tiansuo Zhao, Xiuchao Wang, Yukuan Feng, Hongwei Wang, Song Gao, Shengyu Yang, Yi Shi, Jing Liu, Antao Chang, Chongbiao Huang, Jihui Hao   +18 more
semanticscholar   +1 more source

Decreased Gut Microbiome Tryptophan Metabolism and Serotonergic Signaling in Patients With Persistent Mental Health and Gastrointestinal Symptoms After COVID-19

Clinical and Translational Gastroenterology, 2022
INTRODUCTION: An estimated 15%–29% of patients report new gastrointestinal (GI) symptoms after coronavirus-19 disease (COVID-19) while 4%–31% report new depressive symptoms.
John W. Blackett, Yiwei Sun, L. Purpura, K. Margolis, M. Elkind, Sheila O'Byrne, M. Wainberg, J. Abrams, Harris H. Wang, Lin Chang, D. Freedberg   +10 more
semanticscholar   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Gut Microbiota−Tryptophan Metabolism−GLP-1 Axis Participates in β-Cell Regeneration Induced by Dapagliflozin

Diabetes
Sodium–glucose cotransporter 2 inhibitors, efficacious antidiabetic agents that have cardiovascular and renal benefits, can promote pancreatic β-cell regeneration in type 2 diabetic mice. However, the underlying mechanism remains unclear.
Yafei Jiang, Jin Yang, Li Xia, Tianjiao Wei, Xiaona Cui, Dandan Wang, Zirun Jin, Xiafang Lin, Fei Li, Kun Yang, Shan Lang, Ye Liu, Jing Hang, Zhe Zhang, T. Hong, Rui Wei   +15 more
semanticscholar   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source