Results 71 to 80 of about 1,375,182 (353)

Identification of tryptophan metabolic gene-related subtypes, development of prognostic models, and characterization of tumor microenvironment infiltration in gliomas

Frontiers in Molecular Neuroscience, 2022
BackgroundEpigenetic regulation and immunotherapy of tumor microenvironment (TME) is a hot topic in recent years. However, the potential value of tryptophan metabolism genes in regulating TME and immunotherapy is still unclear.Materials and methodsA ...
Yi Liu, Yi Liu, Juan Xiang, Yiwei Liao, Gang Peng, Gang Peng, Chenfu Shen, Chenfu Shen   +7 more
doaj   +1 more source

Tryptophan Metabolism and COVID-19-Induced Skeletal Muscle Damage: Is ACE2 a Key Regulator?

Frontiers in Nutrition, 2022
The severity of coronavirus disease 2019 (COVID-19) is characterized by systemic damage to organs, including skeletal muscle, due to excessive secretion of inflammatory cytokines.
H. Takeshita, Koichi Yamamoto
semanticscholar   +1 more source

Differential Compartmentalization of Enzymatic Reactions for Lactate Signaling Across Protocells

Advanced Functional Materials, EarlyView.
Two populations of protocells consisting of giant unilamellar vesicles containing active species and distinct artificial organelles are competent of collective behavior by mimicking production, intercellular communication, and detection of the bioinspired signal molecule lactate. Enzymatic cascade reactions within artificial organelles demonstrate that
Arianna Balestri, Xinan Huang, Emanuel Lörtscher, Cora‐Ann Schoenenberger, Cornelia G. Palivan   +4 more
wiley   +1 more source

Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis

Biology Direct
Background Precision oncology’s implementation in clinical practice faces significant constraints due to the inadequacies in tools for detailed patient stratification and personalized treatment methodologies.
Fan Li, Haiyi Hu, Liyang Li, Lifeng Ding, Zeyi Lu, Xudong Mao, Ruyue Wang, Wenqin Luo, Yudong Lin, Yang Li, Xianjiong Chen, Ziwei Zhu, Yi Lu, Chenghao Zhou, Mingchao Wang, Liqun Xia, Gonghui Li, Lei Gao   +17 more
doaj   +1 more source

The microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut

Cell Reports
Summary: Chronic stress disrupts microbiota-gut-brain axis function and is associated with altered tryptophan metabolism, impaired gut barrier function, and disrupted diurnal rhythms.
Cassandra E. Gheorghe, Sarah-Jane Leigh, Gabriel S.S. Tofani, Thomaz F.S. Bastiaanssen, Joshua M. Lyte, Elisa Gardellin, Ashokkumar Govindan, Conall Strain, Sonia Martinez-Herrero, Michael S. Goodson, Nancy Kelley-Loughnane, John F. Cryan, Gerard Clarke   +12 more
doaj   +1 more source

Cancer immunotherapy by targeting IDO1/TDO and their downstream effectors

Frontiers in Immunology, 2015
The tryptophan to kynurenine metabolic pathway is now firmly established as a key regulator of innate and adaptive immunity. A plethora of preclinical models suggests that this immune tolerance pathway - driven by the key and rate-limiting enzymes ...
Michael ePlatten, Nikolaus evon Knebel Doeberitz, Iris eOezen, Wolfgang eWick, Katharina eOchs   +4 more
doaj   +1 more source

Tryptophan metabolite-regulated Treg responses contribute to attenuation of airway inflammation during specific immunotherapy in a mouse asthma model

Human Vaccines & Immunotherapeutics, 2020
In allergen-specific immunotherapy for asthma, antigens attached to dendritic cells increase the tryptophan metabolism in these cells and alter the Th17/Treg balance in the airways.
Qi Hu, Ling Jin, Jing Zeng, Jinyu Wang, Shimin Zhong, Wenting Fan, Wei Liao   +6 more
doaj   +1 more source

Aryl hydrocarbon receptor activation by Lactobacillus reuteri tryptophan metabolism alleviates Escherichia coli-induced mastitis in mice

PLoS Pathogens, 2021
The intestinal microbiota has been associated with the occurrence and development of mastitis, which is one of the most serious diseases of lactating women and female animals, but the underlying mechanism has not yet been elucidated.
Caijun Zhao, Xiaoyu Hu, Lijuan Bao, Keyi Wu, Lianjun Feng, Min Qiu, Haoyang Hao, Yunhe Fu, Nai-sheng Zhang   +8 more
semanticscholar   +1 more source

Catalytic TiO2 with Self‐Assembled Monolayer for Highly Sensitive, Selective, and Non‐Invasive Monitoring of Sweat L‐Cysteine

Advanced Functional Materials, EarlyView.
A self‐assembled monolayer of 3‐mercaptopropyltrimethoxysilane (MPTS) molecular receptor and titanium oxide‐modified carbon cloth (MPTS/TiO2/CC) was synthesized for the specific detection of sweat L‐cysteine, which is associated with the precision neutrition, cardiovascular system and neuro system.
Xiangjie Chen, Jia Zhu, Jian Shao, Taisong Pan, Guang Yao, Min Gao, Jian Yang, Rui Zhao, Libin Huang, Tao Li, Huanyu Cheng, Yuan Lin   +11 more
wiley   +1 more source

Sophisticated crosstalk of tryptophan-derived metabolites in plant stress responses

Plant Communications
Plants are frequently threatened by diverse stresses that severly impact their health and constrain crop productivity worldwide. Metabolic regulation serves as an important strategy for enhancing plant stress tolerance.
Shuang Wang, Xia Zhang, Dao-Hong Gong, Qiu-Qian Huang, W.M.W.W. Kandegama, Milen I. Georgiev, Yang-Yang Gao, Pan Liao, Ge-Fei Hao   +8 more
doaj   +1 more source