Results 71 to 80 of about 1,400,417 (341)

Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis

Biology Direct
Background Precision oncology’s implementation in clinical practice faces significant constraints due to the inadequacies in tools for detailed patient stratification and personalized treatment methodologies.
Fan Li, Haiyi Hu, Liyang Li, Lifeng Ding, Zeyi Lu, Xudong Mao, Ruyue Wang, Wenqin Luo, Yudong Lin, Yang Li, Xianjiong Chen, Ziwei Zhu, Yi Lu, Chenghao Zhou, Mingchao Wang, Liqun Xia, Gonghui Li, Lei Gao   +17 more
doaj   +1 more source

Prognosis prediction and tumor immune microenvironment characterization based on tryptophan metabolism-related genes signature in brain glioma

Frontiers in Pharmacology, 2022
Glioma is the most common malignant tumor in the central nervous system with no significant therapeutic breakthrough in recent years. Most attempts to apply immunotherapy in glioma have failed.
Shuxin Zhang, Shuxin Zhang, Siliang Chen, Zhihao Wang, Junhong Li, Yunbo Yuan, Wentao Feng, Wenhao Li, Mina Chen, Yanhui Liu   +9 more
doaj   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Sophisticated crosstalk of tryptophan-derived metabolites in plant stress responses

Plant Communications
Plants are frequently threatened by diverse stresses that severly impact their health and constrain crop productivity worldwide. Metabolic regulation serves as an important strategy for enhancing plant stress tolerance.
Shuang Wang, Xia Zhang, Dao-Hong Gong, Qiu-Qian Huang, W.M.W.W. Kandegama, Milen I. Georgiev, Yang-Yang Gao, Pan Liao, Ge-Fei Hao   +8 more
doaj   +1 more source

Cancer immunotherapy by targeting IDO1/TDO and their downstream effectors

Frontiers in Immunology, 2015
The tryptophan to kynurenine metabolic pathway is now firmly established as a key regulator of innate and adaptive immunity. A plethora of preclinical models suggests that this immune tolerance pathway - driven by the key and rate-limiting enzymes ...
Michael ePlatten, Nikolaus evon Knebel Doeberitz, Iris eOezen, Wolfgang eWick, Katharina eOchs   +4 more
doaj   +1 more source

Tryptophan metabolite-regulated Treg responses contribute to attenuation of airway inflammation during specific immunotherapy in a mouse asthma model

Human Vaccines & Immunotherapeutics, 2020
In allergen-specific immunotherapy for asthma, antigens attached to dendritic cells increase the tryptophan metabolism in these cells and alter the Th17/Treg balance in the airways.
Qi Hu, Ling Jin, Jing Zeng, Jinyu Wang, Shimin Zhong, Wenting Fan, Wei Liao   +6 more
doaj   +1 more source

Identification of tryptophan metabolic gene-related subtypes, development of prognostic models, and characterization of tumor microenvironment infiltration in gliomas

Frontiers in Molecular Neuroscience, 2022
BackgroundEpigenetic regulation and immunotherapy of tumor microenvironment (TME) is a hot topic in recent years. However, the potential value of tryptophan metabolism genes in regulating TME and immunotherapy is still unclear.Materials and methodsA ...
Yi Liu, Yi Liu, Juan Xiang, Yiwei Liao, Gang Peng, Gang Peng, Chenfu Shen, Chenfu Shen   +7 more
doaj   +1 more source

Microbial Tryptophan Metabolism Tunes Host Immunity, Metabolism, and Extraintestinal Disorders

Metabolites, 2022
The trillions of commensal microorganisms comprising the gut microbiota have received growing attention owing to their impact on host physiology. Recent advances in our understandings of the host–microbiota crosstalk support a pivotal role of microbiota ...
Moyan Liu, M. Nieuwdorp, W. D. de Vos, E. Rampanelli   +3 more
semanticscholar   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

The Kynurenine Pathway: a Proposed Mechanism Linking Diabetes and Periodontal Disease in Diabetic Patients

Dental Hypotheses, 2011
Introduction: Diabetes mellitus is a metabolic disease characte-rized by dysregulation of carbohydrate, protein and lipid metabolism. Diabetes could result, in part, in activation of tryptophan metabolism.
Rishabh Kapila, KS Nagesh, Asha R. Iyengar, Subash BV. Adiga   +3 more
doaj