Results 91 to 100 of about 855,125 (282)

Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A

Angewandte Chemie, EarlyView.
Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham, Edward S. Hems, Daniel C. L. Van, Justin E. Clarke, Sergey Nepogodiev, Julius S. P. Adamson, Christian Bassi, Michael E. Webb, Glyn R. Hemsworth, Orde Q. Munro, Barrie Wilkinson, Ryan F. Seipke   +11 more
wiley   +2 more sources

Biomimetic Polymerization of Tellurocysteine: Breaking the Natural Amino Acid Radioprotection Limitation

Advanced Science, EarlyView.
Inspired by natural amino acid polymer‐melanin systems, this study strategically incorporated tellurocysteine to develop advanced radiation‐shielding materials. This approach transformed the primary interaction mechanism between melanin‐based materials and incident photons from Compton scattering to the photoelectric effect. Tellurocysteine‐polymerized
Wei Chen, Hanjie Zhu, Yue Zhang, Yuqing Qiao, Ruotong Deng, Huaping Xu, Wei Cao   +6 more
wiley   +1 more source

RATEX: A Scalable RNA‐Based Platform for Logical and Multi‐Layered Cellular Programming

Angewandte Chemie, EarlyView.
RATEX integrated ribosome‐mediated transcription control with synthetic RNA regulators, enabling simultaneous processing of RNA, metabolite, and small‐molecule inputs through complex logic operations within a single transcript. The platform achieves up to 1,492‐fold gene regulation, multi‐input hybrid logic gates, RNA‐programmed signaling cascades, and
Hyunseop Goh, Hansol Kang, Chaeri Kim, Jongmin Kim   +3 more
wiley   +2 more sources

Human gut microbiome composition and tryptophan metabolites were changed differently by fast food and Mediterranean diet in 4 days: a pilot study.

Nutrition Research, 2020
Diets rich in animal source foods vs plant-based diets have different macronutrient composition, and they have been shown to have differential effects on the gut microbiome.
Chenghao Zhu, L. Sawrey-Kubicek, Elizabeth Beals, Chris H. Rhodes, Hannah Houts, Romina Sacchi, Angela M. Zivkovic   +6 more
semanticscholar   +1 more source

Diabetogenic Metabolits of Tryptophan

Bulletin of the Karaganda University “Biology medicine geography Series”
The analysis of results investigations of mechanisms of diabetogenic activity of metabolits of abnormal tryptophan metabolism as Xanthurenic acid (XA) are presented in review. Among more than 30 diabetogenic chemicals widely known today XA only is formed in animals and elderly human as result of disturbances of tryptophan metabolism.
G.G. Meyramov, K.-D. Kohnert, A.S. Shaybek, O.-N. DuPont, A.G. Abdraimova   +4 more
openaire   +1 more source

Enzymatic Basis for the Oxidative Branch of Aromatic Amino Acid Fermentation Leading to p‐cresol Formation

Advanced Science, EarlyView.
In anaerobic bacteria, tyrosine serves as an electron donor in the oxidative Stickland fermentation branch, generating p‐hydroxyphenylacetate, ATP and reduced ferredoxin for decarboxylation into p‐cresol. ABSTRACT The phenolic metabolite p‐cresol is a byproduct of tyrosine fermentation by certain strictly anaerobic bacteria, including the human gut ...
Li Jiang, Yifeng Wei, Xumei Liu, Dazhi Liu, Zhenyu Liu, Yang Tong, Jinyu Yin, Ankanahalli N. Nanjaraj Urs, Meining Xing, Mark A. Harrison, Chuyuan Zhang, Sheng Yang, Yunzi Luo, Ee Lui Ang, Huimin Zhao, Yan Zhang   +15 more
wiley   +1 more source

Immune cells and tryptophan metabolism in the joint capsule tissue in rheumatoid arthritis

Acta Biomedica Scientifica
To the present day, many links in the pathogenesis of rheumatoid arthritis remain unclear, which leads to unsatisfactory results in its therapy.The aim.
E. A. Stepanov
doaj   +1 more source

Comprehensive assessment of multiple tryptophan metabolites as potential biomarkers for immune checkpoint inhibitors in patients with non-small cell lung cancer

Clinical and Translational Oncology, 2020
Purpose Tryptophan metabolites have immunomodulatory functions, suggesting possible roles in cancer immunity. Methods Plasma tryptophan metabolites were measured using liquid chromatography/mass spectrometry before immune checkpoint inhibitors (ICIs) in ...
M. Karayama, J. Masuda, K. Mori, H. Yasui, H. Hozumi, Y. Suzuki, K. Furuhashi, T. Fujisawa, N. Enomoto, Y. Nakamura, N. Inui, T. Suda, M. Maekawa, H. Sugimura, A. Takada   +14 more
semanticscholar   +1 more source

Chitosan‐Carbon Dot Composite Materials Form a Leaf Surface Barrier to Mitigate the Enrichment and Invasion of Nanoplastics: From Leaf Interface to Systemic Response

Advanced Science, EarlyView.
Foliar spraying of CS‐CDs can form a film on the leaves of Brassica rapa, effectively reducing the enrichment and absorption of PS in the leaves, while increasing the biomass and nutrient content of the plants. In addition, CS‐CDs can also enrich the interfoliar microbial community and activate the plant's own defense metabolic pathways.
Beibei Zhao, Mei Li, Mengjiao Fan, Chuanhuan Liu, Jie Jiang, Jia Song, Yingzhu Liu   +6 more
wiley   +1 more source

Tryptophan Metabolites Are Associated With Symptoms and Nigral Pathology in Parkinson's Disease

Movement Disorders, 2020
The objective of this study was to determine whether neurotoxic kynurenine metabolites, induced by inflammation, in plasma and cerebrospinal fluid (CSF) are associated with symptom severity and nigral pathology in Parkinson's disease (PD).
Patrick L Heilman, Ernest W Wang, M. Lewis, S. Krzyzanowski, Colt D. Capan, Amanda R Burmeister, G. Du, Martha L. Escobar Galvis, P. Brundin, Xuemei Huang, L. Brundin   +10 more
semanticscholar   +1 more source