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Neurotoxicity of tryptophan metabolites
Biochemical Society Transactions, 2007The metabolism of tryptophan by the kynurenine pathway leads to the production of several neurotoxic compounds, some of which have been associated with neurological disorders. Recent investigation of some relevant compounds in this pathway has provided further evidence of their neurotoxicity.
A J, Smith, T W, Stone, R A, Smith
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Activation of the Ah Receptor by Tryptophan and Tryptophan Metabolites
Biochemistry, 1998The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of a variety of hydrophobic natural and synthetic chemicals, including the environmental contaminant 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin). A variety of indole-containing chemicals, such as indole-3-
Heath-Pagliuso, S. +6 more
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Tryptophan Metabolites and Brain Disorders
Clinical Chemistry and Laboratory Medicine, 2003Tryptophan is metabolised primarily along the kynurenine pathway, of which two components are now known to have marked effects on neurons in the central nervous system. Quinolinic acid is an agonist at the population of glutamate receptors which are sensitive to N-methyl-D-aspartate (NMDA), and kynurenic acid is an antagonist at several glutamate ...
Trevor W, Stone +4 more
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Microanalysis of tryptophan metabolites in mice
Analytical Biochemistry, 1974Abstract Techniques were devised to quantitatively monitor a wide variety of tryptophan metabolites in a single mouse urine sample. Behavior of reference tryptophan standards on two-dimensional thin layer and DEAE-cellulose chromatography as well as fluorescence and color reactions were used to identify urinary tryptophan metabolites. The use of d,l
K M, Morris, R J, Moon
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Chromatographic separation of tryptophan metabolites
Analytical Biochemistry, 1970Abstract Separation of tryptophan and 15 metabolites by ion-exchange chromatography using Sephadex QAE-A25 and carboxymethyleellulose in a continuous system is reported. The system employs a complex NaCl gradient to elute the QAE-A25 column, and a simple linear NaCl gradient to elute the CMC column.
M, Bakri, J R, Carlson
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Tryptophan and indolic tryptophan metabolites in chronic renal failure
The American Journal of Clinical Nutrition, 1980Tryptophan and indolic tryptophan metabolites were measured in the serum of normal subjects and chronic renal failure patients. The tryptophan free/total ratio was 0.07 in the normal serum, but the other tryptophan metabolite values were below detectable levels.
A, Saito +5 more
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Kynurenine metabolites of tryptophan
Neurology, 1990Over the past 2 decades, a number of studies have demonstrated that amino acids act as precursors for the biosynthesis of a variety of neuroactive compounds, including catecholamines and indoleamines. For example, the aromatic amino acid L-tryptophan is a precursor for serotonin biosynthesis.
A, Freese +3 more
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Tryptophane Metabolites in Human Urine
Nature, 1953I HAVE already reported1 that some human urine specimens made strongly alkaline yield distillates presenting spectroscopic and polarographic properties of o-aminoacetophenone. This was interpreted as indicating the presence of kynurenine in human urine, since (1) o-aminoacetophenone is not present in untreated urine, and (2) no substance other than ...
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A method for the determination of urinary metabolites of tryptophan
Clinica Chimica Acta, 1971Abstract A method is described for the estimation of the urinary tryptophan metabolites, 3-hydroxy-anthranilic acid, l -kynurenine, 3-hydroxy-kynurenine and xanthurenic acid. They were separated by thin-layer chromatography and measured fluorimetrically.
E D, Bell, W I, Waring
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Determination of Tryptophan and Tryptophan Metabolites in Grape Must and Wine
1999Tryptophan (Trp) and its metabolites, especially indole-3-acetic acid (IAA), are considered as potential precursors of 2-aminoacetophenone (AAP), an aroma compound which causes the "untypical aging off-flavor" (UTA) in Vitis vinifera white wines. In this study RP-HPLC with fluorescence detection was used for the qualitative and quantitative analysis of
K, Hoenicke +5 more
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