Results 91 to 100 of about 18,157 (223)

Data from Plk1-Mediated Phosphorylation of TSC1 Enhances the Efficacy of Rapamycin

, 2023
Zhiguo Li, Yifan Kong, Longzhen Song, Qian Luo, Jinghui Liu, Chen Shao, Xianzeng Hou, Xiaoqi Liu   +7 more
openalex   +1 more source

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source

TSC1 Sets the Rate of Ribosome Export and Protein Synthesis through Nucleophosmin Translation [PDF]

, 2007
Corey Pelletier, Leonard B. Maggi, Suzanne N. Brady, Danielle K. Scheidenhelm, David H. Gutmann, Jason D. Weber   +5 more
openalex   +1 more source

Regulatory mechanism of O‐linked N‐acetylglucosamine protein modification on autophagy in cancer

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
O‐GlcNAcylation serves as a nutrient and stress sensor that dynamically regulates autophagy at multiple stages in cancer cells. It fine‐tunes autophagy initiation, maturation and fusion by modifying key proteins such as ULK1, ATG4B and SNAP‐29. Context‐dependent O‐GlcNAcylation promotes tumour adaptation and therapy resistance via autophagy remodelling.
Yizhan Li, Ling Gao, Shaoming Li, Jingjing Zheng, Keqian Zhi, Wenhao Ren   +5 more
wiley   +1 more source

Erratum: Novel TSC1 mutation associated with variable phenotypes in tuberous sclerosis (DOI: 10.1556/OH.2013.29634) [PDF]

, 2013
Erzsébet Kövesdi, Kinga Hadzsiev, Katalin Komlósi, Mária Kassay, Péter Barsi, Béla Melegh   +5 more
openalex   +1 more source

TFE3‐Rearranged PEComa(‐Like Neoplasm) of the Chest Wall Diagnosed by Fine‐Needle Aspiration: A Case Report

Diagnostic Cytopathology, Volume 54, Issue 1, Page E1-E5, January 2026.
ABSTRACT We report a rare TFE3‐rearranged perivascular epithelioid cell tumor (PEComa) of the parasternal chest wall diagnosed preoperatively by fine‐needle aspiration (FNA) cytology. The smears and cell block showed epithelioid cells with clear to granular cytoplasm and prominent nucleoli.
Shah Dev, Matthew Miller, Tom Hu, Cindy McGrath, Roseann I. Wu   +4 more
wiley   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

Obestatin Treatment Counteracts Muscle Wasting by Reactivation of Autophagy in Duchenne Muscular Dystrophy

MedComm, Volume 7, Issue 1, January 2026.
Obestatin signaling reactivates autophagy by NEDD4‐L activation under DMD conditions. Tyrosine switch on NEDD4‐L activates autoubiquitination that serves as a scaffold to recruit USP10 to form a deubiquitination complex, which stabilizes VPS34 to promote autophagy by activation of the Beclin1 complex. In parallel, NEDD4‐L favors AMPK exposure to CaMKKß
Icía Santos‐Zas, Silvia Costas‐Abalde, Andrea C. Lodeiro, Fátima Fernández‐Barreiro, Tania Cid‐Díaz, Saúl Leal‐López, Jessica González‐Sánchez, Mar García‐Lamela, Lucía Debasa‐Corral, Carlos S. Mosteiro, Kamel Mamchaoui, Vincent Mouly, Xesús Casabiell, Rosalía Gallego, José Luis Relova, Yolanda Pazos, Jesus P. Camiña   +16 more
wiley   +1 more source

Identification of a complex intrachromosomal inverted insertion in the long arm of chromosome 9 as a cause of tuberous sclerosis complex in a Korean family

Molecular Genetics & Genomic Medicine
Background Tuberous sclerosis complex (TSC) is an autosomal dominant multisystem disorder, caused by a loss‐of‐function of either TSC1 or TSC2 gene. However, in 10%–15% TSC patients there is no pathogenic variant identified in either TSC1 or TSC2 genes ...
Seung Woo Ryu, Ji‐Hee Yoon, Dong‐wook Kim, Beomman Han, Heonjong Han, Joohyun Han, Hane Lee, Go Hun Seo, Beom Hee Lee   +8 more
doaj   +1 more source

A brain proteomic investigation of rapamycin effects in the Tsc1 +/− mouse model

Molecular Autism, 2017
Background Tuberous sclerosis complex (TSC) is a rare monogenic disorder characterized by benign tumors in multiple organs as well as a high prevalence of epilepsy, intellectual disability and autism.
Hendrik Wesseling, Ype Elgersma, Sabine Bahn   +2 more
doaj   +1 more source