Results 91 to 100 of about 20,510 (176)

mTORC1 hampers Hedgehog signaling inTsc2deficient cells [PDF]

Life Science Alliance
The mTORC1-complex is negatively regulated by TSC1 and TSC2. Activation of Hedgehog signaling is strictly dependent on communication between Smoothened and the Hedgehog-signaling effector and transcription factor, GLI2, in the primary cilium. Details about this communication are not known, and we wanted to explore this further.
Lasse Jonsgaard Larsen, Elsebet Østergaard, Lisbeth Birk Møller   +2 more
openaire   +3 more sources

LKB1–AMPK Signaling Pathway in Cardiovascular and Other Diseases

MedComm, Volume 7, Issue 3, March 2026.
The LKB1–AMPK pathway has a central regulatory role in various diseases. Dysfunction of this pathway can lead to pathological processes in cardiovascular diseases (atrial fibrillation, myocardial infarction, myocardial hypertrophy, atherosclerosis), metabolic diseases (diabetes and kidney disease), neurodegenerative diseases (Alzheimer's disease ...
Zhuo Chen, Qin Yang, Guo‐Wei He
wiley   +1 more source

Comparison of three rapamycin dosing schedules in A/J Tsc2^+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors

Journal of Translational Medicine, 2010
Background Tuberous Sclerosis Complex (TSC) is an autosomal dominant tumor disorder characterized by the growth of hamartomas in various organs including the kidney, brain, skin, lungs, and heart.
Dabora Sandra L, Nobil Alison, Woodrum Chelsey   +2 more
doaj   +1 more source

Heterozygous Tsc2 (Tsc2+/–) mouse model to study induced renal cancer in response to ionizing radiation at low doses

Carcinogenesis, 2018
Abstract Kidneys are one of the main dose-limiting organs in radiotherapeutic procedures of lower abdomen. Likewise, the threat of exposure of radiosensitive organs such as kidneys in warfare or radiation accidents among military personal or due to terrorist activities in general public is of increasing concern.
Sureshkumar M A, Caroline R Delma, Krishnan Manickam, Sumathy Mohan, Samy L Habib, Mohan Natarajan   +5 more
openaire   +2 more sources

MicroRNAs in Methamphetamine: Addiction, Neurotoxicity, and Therapeutic Potential

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
The use of METH leads to the release of dopamine from the affected brain regions, including the nucleus accumbens (NAc), ventral tegmental area (VTA), prefrontal cortex (PFC), hippocampus (Hip), and striatum. This triggers signals that alter miRNA expression, which in turn leads to differential expression of target genes.
Yacoubou Abdoul Razak Mahaman, An‐Ping Ye, Ya‐Xian Zhang, Ming‐Yu Chen, Fang Huang, Rong Liu, Ying‐Yan Fang, Xiaochuan Wang   +7 more
wiley   +1 more source

mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis

Cellular & Molecular Biology Letters
Background Patients with tuberous sclerosis complex (TSC) develop renal cysts and/or angiomyolipomas (AMLs) due to inactive mutations of either TSC1 or TSC2 and consequential mTOR hyperactivation.
Shuyun Zhao, Shuai Hao, Jiasheng Zhou, Xinran Chen, Tianhua Zhang, Zhaolai Qi, Ting Zhang, Sajid Jalal, Chuanxin Zhai, Lu Yin, Yufei Bo, Hongming Teng, Yue Wang, Dongyan Gao, Hongbing Zhang, Lin Huang   +15 more
doaj   +1 more source

Genome‐wide Identification and expression analysis of TOR signaling pathway components in apple in response to low nitrogen

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Target of rapamycin (TOR) is an evolutionarily conserved serine/threonine kinase that plays a central role in regulating biological growth, development, and stress responses in eukaryotes. However, the TOR signaling pathway has not been thoroughly studied in apple (Malus domestica).
Dehai Liu, Siyuan Cheng, Yanghao Long, Qinyao Jin, Yujie Zhou, Fengwang Ma, Xuan Liu, Xiaoqing Gong   +7 more
wiley   +1 more source

mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis

Cell Reports, 2016
Hyperfunction of the mTORC1 pathway has been associated with idiopathic and syndromic forms of autism spectrum disorder (ASD), including tuberous sclerosis, caused by loss of either TSC1 or TSC2. It remains largely unknown how developmental processes and
Veronica Costa, Stefan Aigner, Mirko Vukcevic, Evelyn Sauter, Katharina Behr, Martin Ebeling, Tom Dunkley, Arno Friedlein, Sannah Zoffmann, Claas A. Meyer, Frédéric Knoflach, Sebastian Lugert, Christoph Patsch, Fatiha Fjeldskaar, Laurie Chicha-Gaudimier, Anna Kiialainen, Paolo Piraino, Marc Bedoucha, Martin Graf, Sebastian Jessberger, Anirvan Ghosh, Josef Bischofberger, Ravi Jagasia   +22 more
doaj   +1 more source

Toward chemotherapy for Tsc2-mutant renal tumor.

Proceedings of the Japan Academy, Series B, 2003
Recent genetic studies of Drosophila melanogaster and subsequent biochemical analysis in mammalian cells revealed that products of tuberous sclerosis genes, TSC1 and TSC2, regulate insulin signaling via suppression of p70 ribosomal S6 subunit-kinase (S6K) activity.
Toshiyuki KOBAYASHI, Hiroyuki ADACHI, Hiroaki MITANI, Youko HIRAYAMA, Okio HINO   +4 more
openaire   +2 more sources

Impact of prenatal sirolimus on cardiac rhabdomyomas and brain tubers

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 3, Page 350-359, March 2026.
ABSTRACT Objective To document the natural progression of fetal cardiac rhabdomyomas and evaluate the impact of prenatal sirolimus (PNS) on tumor size, cardiac complications and brain‐tuber size. Methods This was a single‐center retrospective cohort study of pregnancies with suspected fetal cardiac rhabdomyoma referred to our center from April 2013 to ...
S. Vergote, L. Van der Veeken, D. Chitayat, E. Jaeggi, G. Ryan, E. Miller, S. Shinar   +6 more
wiley   +1 more source