Results 101 to 110 of about 25,279 (224)
Developmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1004-1025, August 2025.Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes +6 more
wiley +1 more source
International Journal of Cancer, Volume 157, Issue 2, Page 305-316, 15 July 2025.What's new? Cervical cancer screening programmes could benefit from an accurate triage test for human papillomavirus‐positive women based on self‐sampling. This epigenome‐wide association study examined a large number of cervical cancers and cervical intraepithelial neoplasias grade 3 (CIN3) compared to controls using the 850 k EPIC methylation array ...
Sarah J. Bowden +9 more
wiley +1 more source
TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms
Cellular and Molecular Life Sciences, 2018 Primary cilia are sensory organelles that coordinate multiple cellular signaling pathways, including Hedgehog (HH), Wingless/Int (WNT) and Transforming Growth Factor-β (TGF-β) signaling. Similarly, primary cilia have been implicated in regulation of mTOR
T. Rosengren +4 more
semanticscholar +1 more source
Advanced Science, Volume 12, Issue 26, July 10, 2025.Neural precursor cell expressed developmentally down‐regulated gene 4‐like (NEDD4L) prevents colorectal cancer liver metastasis through ubiquitination and degradation of protein arginine methyltransferase 5 (PRMT5). PRMT5 degradation attenuates the methylarginine of AKT1.
Zhewen Dong +8 more
wiley +1 more source
Clinical Cancer Research, 2018 Purpose: Genomic alterations in key components of PI3K/mTOR pathway have been proposed as candidate predictive markers for rapalog therapy in renal cell carcinoma (RCC). We tested this hypothesis in patients from a randomized phase II trial of everolimus
M. Voss +14 more
semanticscholar +1 more source
Interconnections of insulin/IGF‐1 signaling and autophagy abnormalities in Alzheimer's disease
Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.Abstract INTRODUCTION Impaired insulin (INS) and insulin‐like growth factor 1 (IGF‐1) signaling are features of both brain aging and late‐onset Alzheimer's disease (LOAD). However, their exact underlying mechanisms and cause‐and‐effect linkages, including the downstream regulation of endocytosis and autophagy, are still not well understood.
Wang Liao +13 more
wiley +1 more source
Neurobiology of Disease, 2017 Tuberous sclerosis complex (TSC) is a rare, genetic disease caused by loss-of-function mutations in either TSC1 or TSC2. Patients with TSC are neurologically characterized by the presence of abnormal brain structure, intractable epilepsy and TSC ...
Chloë Scheldeman +11 more
doaj
Identification of a nonsense mutation at the 5' end of the TSC2 gene in a family with a presumptive diagnosis of tuberous sclerosis complex. [PDF]
, 1996 Radek Vrtěl +14 more
openalex +1 more source
Cancer Medicine, Volume 14, Issue 13, July 2025.ABSTRACT Aim To investigate the mechanistic aspects of inflammation and oxidative stress and their association with thyroid cancer risk. Methods We have systematically searched the PubMed and Web of Science databases to perform a comprehensive analysis of the pathogenic mechanisms that link obesity, inflammation, and oxidative stress to thyroid cancer.
Bo‐Tao Zhang +4 more
wiley +1 more source