Results 11 to 20 of about 25,325 (232)

TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase [PDF]

Journal of Biological Chemistry, 2021
Tuberous sclerosis complex (TSC) is an autosomal dominant disease characterized by hamartoma formation in various organs. Two genes responsible for the disease, TSC1 and TSC2, have been identified.
Inoki, Ken, Zhu, Tianqing, Li, Yong, Guan, Kun-Liang, Garcia Gonzalo, Francesc, Rosa López, José Luis, Chong-Kopera, Huira   +6 more
core   +5 more sources

The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits [PDF]

BMC Biochemistry, 2012
Background: Mutations to the TSC1 and TSC2 genes cause the disease tuberous sclerosis complex. The TSC1 and TSC2 gene products form a protein complex that integrates multiple metabolic signals to regulate the activity of the target of rapamycin (TOR ...
Hoogeveen-Westerveld, M. (Marianne), Halley, Dicky, Leontine van Unen, Hoogeveen, Andre, Halley, D.J.J. (Dicky), Ans van den Ouweland, Nellist, M.D. (Mark), Unen, Leontine, Ouweland, A.M.W. (Ans) van den, Hoogeveen, A.T. (Andre), Hoogeveen - Westerveld, Marianne, Mark Nellist, Unen, L. (Leontine) van, Marianne Hoogeveen-Westerveld, Nellist, Mark, van den Ouweland, Ans, Dicky Halley, Andre Hoogeveen, Unen, Leontine; id_orcid   +18 more
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Lymphangioleiomyomatosis and TSC2-/- cells [PDF]

Lymphatic Research and Biology, 2010
The cells comprising pulmonary lymphangioleiomyomatosis (LAM) and renal angiomyolipomas (AMLs) are heterogeneous, with variable mixtures of cells exhibiting differentiation towards smooth muscle, melanocytic, and lymphatic or blood endothelial cells ...
G. Pacheco Rodriguez, T. N. Darling, J. Moss, E. Lesma, C. Walker, A. Gorio   +5 more
core   +3 more sources

Regulation of TSC2 lysosome translocation and mitochondrial turnover by TSC2 acetylation status

Scientific Reports
Sirtuin1 (SIRT1) activity decreases the tuberous sclerosis complex 2 (TSC2) lysine acetylation status, inhibiting the mechanistic target of rapamycin complex 1 (mTORC1) signalling and concomitantly, activating autophagy.
García, Gema, Iglesias Fortes, Sara, Jiménez, Beatriz, Marqués, Patricia, Lockwood, Ángela, Burillo Maldonado, Jesús, Guillén Viejo, Carlos, Guillén, Carlos, González Blanco, Carlos, García Aguilar, Ana   +9 more
core   +7 more sources

The methylation of the TSC2 promoter underlies the abnormal growth of TSC2 angiomyolipoma-derived smooth muscle cells [PDF]

The American Journal of Pathology, 2009
Tuberous sclerosis complex (TSC) is an autosomal-dominant disease that is caused by mutations in either the TSC1 or TSC2 gene. Smooth muscle-like cells (ASMs) were isolated from an angiomyolipoma of a patient with TSC.
F. Ghelma, S. Ancona, E. Montanari, SM. Sirchia, S. Bosari, AM. Di Giulio, S. Carelli, E. Lesma, A. Gorio   +8 more
core   +5 more sources

TSC2 (tuberous sclerosis 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2002
Review on TSC2 (tuberous sclerosis 2), with data on DNA, on the protein encoded, and where the gene is ...
Petri, Henske E, Astrinidis, A
core   +3 more sources

Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish

Disease Models & Mechanisms, 2013
SUMMARY Tuberous sclerosis complex (TSC) is a multi-organ disorder caused by mutations of the TSC1 or TSC2 genes. A key function of these genes is to inhibit mTORC1 (mechanistic target of rapamycin complex 1) kinase signaling. Cells deficient for TSC1 or
Seok-Hyung Kim, Marie L. Kowalski, Robert P. Carson, L. Richard Bridges, Kevin C. Ess   +4 more
doaj   +2 more sources

TSC2 gene characterization and mechanism of ammonia nitrogen stress inhibiting growth through AMPK/mTOR pathway mediated by TSC2 in Megalobrama amblycephala

Aquaculture Reports
This study was performed to evaluate the role of TSC2 (tuberous sclerosis complex 2) in the regulation of growth inhibition of fish exposed to chronic ammonia nitrogen.
Xiangyang Yuan, Qian Wang, Mengyang Dai, Hengjie Wang, Xinyu Xiong, Liang Pan, Canli Wang   +6 more
doaj   +2 more sources

Tsc2 coordinates neuroprogenitor differentiation

iScience, 2023
Neural stem cells (NSCs) of the ventricular-subventricular zone (V-SVZ) generate numerous cell types. The uncoupling of mRNA transcript availability and translation occurs during the progression from stem to differentiated states. The mTORC1 kinase pathway acutely controls proteins that regulate mRNA translation.
Victoria A. Riley, Vijay Shankar, Jennie C. Holmberg, Aidan M. Sokolov, Victoria N. Neckles, Kaitlyn Williams, Rachel Lyman, Trudy F.C. Mackay, David M. Feliciano   +8 more
openaire   +3 more sources

A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles [PDF]

Human Molecular Genetics, 2009
Tuberous sclerosis complex (TSC) is a tumor suppressor gene syndrome in which hamartomas develop in multiple organ systems. Knockout and conditional alleles of Tsc1 and Tsc2 have been previously reported. Here, we describe the generation of a novel hypomorphic allele of Tsc2 (del3), in which exon 3, encoding 37 amino acids near the N terminus of ...
Kristen, Pollizzi, Izabela, Malinowska-Kolodziej, Cheryl, Doughty, Charles, Betz, Jian, Ma, June, Goto, David J, Kwiatkowski   +6 more
openaire   +2 more sources