Results 21 to 30 of about 23,999 (238)

Regulation of the mammalian target of rapamycin complex 2 (mTORC2) [PDF]

, 2006
The growth controlling mammalian Target of Rapamycin (mTOR) is a conserved Ser/Thr kinase found in two structurally and functionally distinct complexes, mTORC1 and mTORC2.
Molle, Klaus-Dieter
core   +1 more source

Clinical and Molecular Spectrum of Tuberous Sclerosis Complex Patients: Identification of Three Novel Mutations

Erciyes Medical Journal, 2020
Objective: Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous syndrome. TSC arises from mutations in either TSC1, at 9q34, or TSC2, at 16p13.3. Skin lesions, such as hypomelanotic macules, facial angiofibromas, shagreen patches, and
Esra Işık, Hüseyin Onay, Tahir Atık, Aslı Ece Solmaz, Demet Terek, Sarenur Gökben, Hasan Tekgül, Ertürk Levent, Mehmet Kantar, Nilgün Kültürsay, Özgür Çoğulu, Ferda Özkınay   +11 more
doaj   +1 more source

Akt phosphorylates both Tsc1 and Tsc2 in Drosophila, but neither phosphorylation is required for normal animal growth. [PDF]

PLoS ONE, 2009
Akt, an essential component of the insulin pathway, is a potent inducer of tissue growth. One of Akt's phosphorylation targets is Tsc2, an inhibitor of the anabolic kinase TOR. This could account for part of Akt's growth promoting activity.
Sibylle Schleich, Aurelio A Teleman
doaj   +1 more source

two variants of TSC2

, 2021
These're the raw sequencing results of two TSC2 ...
Chenchen Zhang
core   +1 more source

Phosphorylation and Functional Inactivation of TSC2 by Erk [PDF]

Cell, 2005
SummaryTuberous sclerosis (TSC) is a tumor syndrome caused by mutation in TSC1 or TSC2 genes. TSC tumorigenesis is not always accompanied by loss of heterozygosity (LOH).
Ma, Li, Chen, Zhenbang, Erdjument-Bromage, Hediye, Tempst, Paul, Pandolfi, Pier Paolo   +4 more
openaire   +2 more sources

Tuberous sclerosis complex: Clinical spectrum and epilepsy: A retrospective chart review study

Translational Neuroscience, 2018
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic neurocutaneous disorder, with heterogeneous manifestations. We aimed to review the clinical presentation of TSC and its association with epilepsy among Saudi population.
Almobarak Sulaiman, Almuhaizea Mohammad, Abukhaled Musaad, Alyamani Suad, Dabbagh Omar, Chedrawi Aziza, Khan Sameena, Aldhalaan Hesham   +7 more
doaj   +1 more source

Single giant mediastinal rhabdomyoma as a sole manifestation of TSC in foetus

Biomedical Papers, 2017
Background: Presence of multiple cardiac rhabdomyomas is one of the major features of Tuberous sclerosis (TSC), but isolated progressing single giant rhabdomyoma is very rare and not typical of TSC.
Marek Godava, Hana Filipova, Lubomir Dubrava, Radek Vrtel, Kamila Michalkova, Maria Janikova, Lenka Bakaj-Zbrozkova, Jiri Navratil   +7 more
doaj   +1 more source

Loss of Tuberous Sclerosis Complex 2 (TSC2) as a Predictive Biomarker of Response to mTOR Inhibitor Treatment in Patients with Hepatocellular Carcinoma

Translational Oncology, 2016
BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death globally. Mechanistic target of rapamycin (mTOR) is frequently up-regulated in HCC and plays an important role in HCC tumorigenesis.
Jinhyun Cho, Jeeyun Lee, Jusun Kim, Seung Tae Kim, Sujin Lee, Sun Young Kim, Sang Yun Ha, Cheol-Keun Park, Ho Yeong Lim   +8 more
doaj   +1 more source

Targeting SPHK1/S1PR3-regulated S-1-P metabolic disorder triggers autophagic cell death in pulmonary lymphangiomyomatosis (LAM)

Cell Death and Disease, 2022
Lymphangioleiomyomatosis (LAM), a progressive pulmonary disease exclusively affecting females, is caused by defects or mutations in the coding gene tuberous sclerosis complex 1 (TSC1) or TSC2, causing the mammalian target of rapamycin complex 1 (mTORC1 ...
Fei Li, Yifan Zhang, Zhoujun Lin, Lizhong Yan, Qiao Liu, Yin Li, Xiaolin Pei, Ya Feng, Xiao Han, Juan Yang, Fangxu Zheng, Tianjiao Li, Yupeng Zhang, Zhenkun Fu, Di Shao, Jane Yu, Chenggang Li   +16 more
doaj   +1 more source

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling [PDF]

, 2009
BackgroundMammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion ...
Trevor C F Tsang, Roberge, Michel, Bruno D Fonseca, Patrick Lajoie, Tsang, Trevor C. F., Lajoie, Patrick, Proud, Christopher G., Aruna D Balgi, Michel Roberge, Tsang Trevor C. F., Ivan R Nabi, Lajoie, P., Nabi Ivan R., Fonseca, B., Balgi, Aruna D., Fonseca, Bruno D., Proud, C., Tsang, T., Balgi, A., Nabi, Ivan R., Roberge, M., Balgi Aruna D., Proud Christopher G., Lajoie Patrick, Roberge Michel, Donohue, Elizabeth, Christopher G Proud, Donohue Elizabeth, Nabi, I., Fonseca Bruno D., Donohue, E., Elizabeth Donohue   +31 more
core   +1 more source