Results 21 to 30 of about 25,325 (232)
TSC1/TSC2 signaling in the CNS [PDF]
FEBS Letters, 2011 Over the past several years, the study of a hereditary tumor syndrome, tuberous sclerosis complex (TSC), has shed light on the regulation of cellular proliferation and growth. TSC is an autosomal dominant disorder that is due to inactivating mutations in TSC1 or TSC2 and characterized by benign tumors (hamartomas) involving multiple organ systems.
Han, Juliette M., Sahin, Mustafa
openaire +2 more sources
Hypo-Expression of Tuberin Promotes Adenomyosis via the mTOR1-Autophagy Axis
Frontiers in Cell and Developmental Biology, 2021 Adenomyosis (AM) is a disease in which endometrial tissue invades the myometrium and has a 10–60% prevalence in reproductive-aged women. TSC2 regulates autophagy via mTOR1 signalling in colorectal cancer and endometrial carcinoma.
Ni-Hao Gu +20 more
doaj +1 more source
Loss of myeloid Tsc2 predisposes to angiotensin II-induced aortic aneurysm formation in mice
Cell Death and Disease, 2022 Rationale Genetic studies have proved the involvement of Tuberous sclerosis complex subunit 2 (Tsc2) in aortic aneurysm. However, the exact role of macrophage Tsc2 in the vascular system remains unclear.
Xue Liu +4 more
doaj +1 more source
Regulation of the mammalian target of rapamycin complex 2 (mTORC2) [PDF]
, 2006 The growth controlling mammalian Target of Rapamycin (mTOR) is a conserved Ser/Thr kinase found in two structurally and functionally distinct complexes, mTORC1 and mTORC2.
Molle, Klaus-Dieter
core +1 more source
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling [PDF]
, 2009 BackgroundMammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion ...
Trevor C F Tsang +31 more
core +2 more sources
Tuberous sclerosis complex: Clinical spectrum and epilepsy: A retrospective chart review study
Translational Neuroscience, 2018 Tuberous sclerosis complex (TSC) is an autosomal dominant genetic neurocutaneous disorder, with heterogeneous manifestations. We aimed to review the clinical presentation of TSC and its association with epilepsy among Saudi population.
Almobarak Sulaiman +7 more
doaj +1 more source
Tsc2 shapes olfactory bulb granule cell molecular and morphological characteristics
Frontiers in Molecular Neuroscience, 2022 Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations that inactivate TSC1 or TSC2. Hamartin and tuberin are encoded by TSC1 and TSC2 which form a GTPase activating protein heteromer that inhibits the Rheb GTPase from ...
Victoria A. Riley +3 more
doaj +1 more source
Вавиловский журнал генетики и селекции, 2019 Pyrenophora tritici-repentis (Ptr) is the causative agent of tan spot, one of the yield limiting diseases of wheat, rapidly increasing in wheat growing countries including Kazakhstan.
A. М. Kokhmetova +3 more
doaj +1 more source
Akt phosphorylates both Tsc1 and Tsc2 in Drosophila, but neither phosphorylation is required for normal animal growth. [PDF]
PLoS ONE, 2009 Akt, an essential component of the insulin pathway, is a potent inducer of tissue growth. One of Akt's phosphorylation targets is Tsc2, an inhibitor of the anabolic kinase TOR. This could account for part of Akt's growth promoting activity.
Sibylle Schleich, Aurelio A Teleman
doaj +1 more source