Results 31 to 40 of about 23,999 (238)
eLife, 2017 Increased mTORC1 signaling from TSC1/TSC2 inactivation is found in cancer and causes tuberous sclerosis complex (TSC). The role of mesenchymal-derived cells in TSC tumorigenesis was investigated through disruption of Tsc2 in craniofacial and limb bud ...
Peter J Klover +14 more
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Rapamycin regulates Transglutaminase 2 in Tsc2−/− MEFs.
, 2016 (A) Hypothetical Venn diagram of the two major changes in gene expression observed in this study. Rapamycin-regulated transcripts were classified as those that met all four criteria at a statistical cut-off *p 2) of the 39,000 probed genes comparing ...
Wenlong Huang (692950) +1 more
core +2 more sources
A Case of Tuberous Sclerosis Complex with Multiple Organ Involvement Caused by TSC2 Gene Mutation
罕见病研究Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder primarily caused by pathogenic variants in the TSC1 or TSC2 genes. It is characterized by multisystem hamartomatous lesions and neuropsychiatric manifestations.
ZHANG Hongli +11 more
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TSC2 Deficiency Increases PTEN via HIF1α [PDF]
Journal of Biological Chemistry, 2009 Substantial evidence suggests roles of TSC2 and PTEN in the development of cancer predisposition syndromes. Loss of TSC2 results in benign tumors, neurological disorders, and angiomyolipomas. We found that PTEN mRNA and protein levels are elevated in Tsc2(-/-) mouse embryo fibroblasts with concomitant reduction in Akt phosphorylation. Reconstitution of
Lenin, Mahimainathan +9 more
openaire +2 more sources
TSC2-CycB1 interaction is serum and Akt phosphorylation dependent.
, 2019 (A) HEK293 cells were transfected with Flag-TSC2 and CycB1-5xA. 18 hrs post-transfection, cells were washed with PBS and incubated for 2 hrs with different concentrations of serum (indicated as % serum).
Miranda A. Hanna (6194816) +4 more
core +1 more source
Sodium hydroxide enhances the efficacy of rapamycin to suppress proliferation of Tsc2-null mouse embryonic fibroblasts [PDF]
Jichu yixue yu linchuang, 2021 Objective To explore the effect of sodium hydroxide(NaOH) and rapamycin(Rapa) alone or their combination in treating Tsc2-null(Tsc2-/-) mouse embryonic fibroblasts.
LI Kai, WANG Ya-nan
doaj
npj Breast Cancer, 2023 HER2-positive breast cancer patients carrying the germline TSC2 nonsynonymous variant c.4349 C > G (p.Pro1450Arg) are resistant to anti-HER2 therapy. Multi-predictor in silico analysis reveals that this variant is deleterious.
Ziyan Yang +7 more
doaj +1 more source
Scientific Reports, 2018 Tuberous Sclerosis Complex (TSC), a rare genetic disorder with mechanistic target of rapamycin complex 1 (mTORC1) hyperactivation, is characterized by multi-organ hamartomatous benign tumors including brain, skin, kidney, and lung ...
Harilaos Filippakis +8 more
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Вавиловский журнал генетики и селекции, 2019 Pyrenophora tritici-repentis (Ptr) is the causative agent of tan spot, one of the yield limiting diseases of wheat, rapidly increasing in wheat growing countries including Kazakhstan.
A. М. Kokhmetova +3 more
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Microglial ASD-related genes are involved in oligodendrocyte differentiation
Scientific Reports, 2021 Autism spectrum disorders (ASD) are associated with mutations of chromodomain-helicase DNA-binding protein 8 (Chd8) and tuberous sclerosis complex 2 (Tsc2).
Yuta Takanezawa +7 more
doaj +1 more source