Results 201 to 210 of about 36,428 (236)

Lessons from Exceptional Responders with High-Grade Brain Tumors Treated with Precision Targeted Therapies. [PDF]

J Immunother Precis Oncol
Dişel U, Kato S, Shreenivas A, Danyeli AE, Ahluwalia MS, Kurzrock R.   +5 more
europepmc   +1 more source

High-throughput bioprinting to produce micropatterned neuroepithelial tissues and model TSC2-deficient brain malformations. [PDF]

Cell Rep Methods
Imani Farahani N, Wong KKL, Allen G, Minhas A, Lin L, Nazir S, Julian LM.   +6 more
europepmc   +1 more source

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Akt regulates growth by directly phosphorylating Tsc2

Nature Cell Biology, 2002
The direct mechanism by which the serine/threonine kinase Akt (also known as protein kinase B (PKB)) regulates cell growth is unknown. Here, we report that Drosophila melanogaster Akt/PKB stimulates growth by phosphorylating the tuberous sclerosis complex 2 (Tsc2) tumour suppressor and inhibiting formation of a Tsc1-Tsc2 complex.
Christopher J Potter, Tian Xu
exaly   +3 more sources

TSC2 alterations in anaplastic ependymoma progression to ependymosarcoma

Clinical Neuropathology, 2020
Ependymosarcomas are rare, biphasic tumors composed of ependymal and sarcomatous components. Due to their rarity, their biologic basis is not well understood. We report the case of a 38-year-old male with anaplastic ependymoma (WHO grade III) that progressed to ependymosarcoma in less than 2 years after multiple resections, chemoradiotherapy, and anti ...
Elisabet, Pujadas, Liam, Chen, Jon D, Weingart, Brent, Orr, Bryam H, Ozer, Matthias, Holdhoff, Fausto J, Rodriguez   +6 more
openaire   +2 more sources

Evolution of the TSC1/TSC2-TOR Signaling Pathway

Science Signaling, 2010
The TSC1/TSC2-TOR signaling pathway evolved from a primitive signaling pathway linking adenosine monophosphate abundance to cell growth.
Jaco, Serfontein, R Ellen R, Nisbet, Christopher J, Howe, Petrus J, de Vries   +3 more
openaire   +3 more sources

Measurements of TSC2 GAP Activity Toward Rheb

2006
Tuberous sclerosis complex (TSC) is a genetic disease caused by mutation in either the tsc1 or tsc2 tumor suppressor genes. TSC1 and TSC2 protein form a physical and functional complex in vivo. Recent studies have demonstrated that TSC2 displays GTPase activating protein (GAP) activity specifically toward the small G protein Rheb (Ras homolog enriched ...
Yong, Li, Ken, Inoki, Haris, Vikis, Kun-Liang, Guan   +3 more
openaire   +2 more sources

Analysis of the TSC2 gene in human medulloblastoma

Acta Neuropathologica, 2001
Medulloblastoma (MB) represents the most frequent malignant brain tumor of childhood. Recent studies have shown that deregulation of developmental control genes may play an important role in its pathogenesis. Tuberous sclerosis is associated with hamartomas and cortical tubers, consisting of both glial and neuronal cellular components.
R, Przkora, B, Meyer-Puttlitz, O, Schmitt, F, Berthold, M, Nöthen, J, Krauss, J C, Tonn, A, von Deimling, O D, Wiestler, T, Pietsch   +9 more
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TSC2/PKD1 Contiguous Gene Deletion Syndrome

Clinical Pediatrics, 2023
Javier Arredondo Montero, Mónica Bronte Anaut, María Velayos, María del Carmen Sarmiento, Carla Ramírez Amorós, Pedro López-Pereira   +5 more
openaire   +2 more sources

The TSC2 Gene and Tuberin

1999
Abstract When a novel gene such as TSC2 is identified, a fundamental point in the associated disease process is defined. Using the gene as a resource, many areas of research can move from descriptive to experimental phases. Analysis of the sequence of the predicted protein product may reveal clues to the molecular and cellular processes ...
openaire   +1 more source