Results 201 to 210 of about 23,999 (238)
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Phosphorylation and binding partner analysis of the TSC1–TSC2 complex
Biochemical and Biophysical Research Communications, 2005Tuberous sclerosis complex (TSC) is an autosomal dominant benign tumour syndrome caused by mutations to either the TSC1 or TSC2 tumour suppressor gene. The TSC1 and TSC2 gene products, TSC1 and TSC2, form a protein complex that integrates inputs from multiple signalling cascades to inactivate the small GTPase rheb, and thereby inhibit mTOR-dependent ...
Mark Nellist +2 more
exaly +4 more sources
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
Cancer Cell, 2003 Inactivation of the TSC2 tumor suppressor protein causes tuberous sclerosis complex (TSC), a disease characterized by highly vascular tumors. TSC2 has multiple functions including inhibition of mTOR (mammalian target of Rapamycin).
Francisca Vazquez
exaly +2 more sources
TSC2 alterations in anaplastic ependymoma progression to ependymosarcoma
Clinical Neuropathology, 2020Ependymosarcomas are rare, biphasic tumors composed of ependymal and sarcomatous components. Due to their rarity, their biologic basis is not well understood. We report the case of a 38-year-old male with anaplastic ependymoma (WHO grade III) that progressed to ependymosarcoma in less than 2 years after multiple resections, chemoradiotherapy, and anti ...
Elisabet, Pujadas +6 more
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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Cell, 2003 Mutations in either the TSC1 or TSC2 tumor suppressor gene are responsible for Tuberous Sclerosis Complex. The gene products of TSC1 and TSC2 form a functional complex and inhibit the phosphorylation of S6K and 4EBP1, two key regulators of translation ...
Ken Inoki, Kun-Liang Guan
exaly +2 more sources
Analysis of the TSC2 gene in human medulloblastoma
Acta Neuropathologica, 2001Medulloblastoma (MB) represents the most frequent malignant brain tumor of childhood. Recent studies have shown that deregulation of developmental control genes may play an important role in its pathogenesis. Tuberous sclerosis is associated with hamartomas and cortical tubers, consisting of both glial and neuronal cellular components.
R, Przkora +9 more
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European Journal of Pediatrics, 2002
Tuberous sclerosis (TSC) is a multisystem disease with manifestations in the central nervous system, skin, kidneys, heart, and other visceral organs. The development of TSC is associated with alterations within a gene on chromosome 9q34 ( TSC1) and a gene on chromosome 16p13 ( TSC2).
Langkau, Nicola +11 more
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Tuberous sclerosis (TSC) is a multisystem disease with manifestations in the central nervous system, skin, kidneys, heart, and other visceral organs. The development of TSC is associated with alterations within a gene on chromosome 9q34 ( TSC1) and a gene on chromosome 16p13 ( TSC2).
Langkau, Nicola +11 more
openaire +3 more sources
Generation of a conditional disruption of the Tsc2 gene
genesis, 2007AbstractTuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in the TSC1 or TSC2 gene. Patients afflicted with TSC develop tumors in various organ systems, but cerebral pathology is particularly severe. Conventional gene disruption of the Tsc1 or Tsc2 gene in mice cause limited central nervous system pathology ...
Omar, Hernandez +3 more
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Evolution of the TSC1/TSC2-TOR Signaling Pathway
Science Signaling, 2010The TSC1/TSC2-TOR signaling pathway evolved from a primitive signaling pathway linking adenosine monophosphate abundance to cell growth.
Jaco, Serfontein +3 more
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