Results 211 to 220 of about 23,999 (238)
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TSC2: filling the GAP in the mTOR signaling pathway
Trends in Biochemical Sciences, 2004The tumor-suppressor proteins TSC1 and TSC2 are associated with an autosomal dominant disorder known as tuberous sclerosis complex (TSC). TSC1 and TSC2 function as a heterodimer to inhibit cell growth and proliferation. Another protein, mTOR (mammalian target of rapamycin), is regarded as a central controller of cell growth in response to growth ...
Yong, Li +3 more
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Akt regulates growth by directly phosphorylating Tsc2
Nature Cell Biology, 2002The direct mechanism by which the serine/threonine kinase Akt (also known as protein kinase B (PKB)) regulates cell growth is unknown. Here, we report that Drosophila melanogaster Akt/PKB stimulates growth by phosphorylating the tuberous sclerosis complex 2 (Tsc2) tumour suppressor and inhibiting formation of a Tsc1-Tsc2 complex.
Christopher J, Potter +2 more
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1999
Abstract When a novel gene such as TSC2 is identified, a fundamental point in the associated disease process is defined. Using the gene as a resource, many areas of research can move from descriptive to experimental phases. Analysis of the sequence of the predicted protein product may reveal clues to the molecular and cellular processes ...
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Abstract When a novel gene such as TSC2 is identified, a fundamental point in the associated disease process is defined. Using the gene as a resource, many areas of research can move from descriptive to experimental phases. Analysis of the sequence of the predicted protein product may reveal clues to the molecular and cellular processes ...
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Measurements of TSC2 GAP Activity Toward Rheb
2006Tuberous sclerosis complex (TSC) is a genetic disease caused by mutation in either the tsc1 or tsc2 tumor suppressor genes. TSC1 and TSC2 protein form a physical and functional complex in vivo. Recent studies have demonstrated that TSC2 displays GTPase activating protein (GAP) activity specifically toward the small G protein Rheb (Ras homolog enriched ...
Yong, Li +3 more
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Mild Expression in Familial TSC2
2004BACKGROUND: TS is an autosomal dominant disorder characterized by hamartomata in various organs, including the brain, and caused by mutations in the TSC1 (9q34) or TSC2 (16p13) genes. The disease phenotype was found to be more severe in sporadic TSC2 patients (Dabora et al, 2001).
Badhwar, Amanpreet +15 more
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TSC2/PKD1 Contiguous Gene Deletion Syndrome
Clinical Pediatrics, 2023Javier Arredondo Montero +5 more
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Neural Development in tsc2-Deficient Zebrafish
2011Abstract : This DOD-funded project Neural Development in tsc2-deficient zebrafish has made excellent progress over the first year of funding. We have essentially completed Task 1 of our Statement of Work with a focus on Neural Development. We have also begun Task 2 determining cell autonomous phenotypes. Using this zebrafish model of tuberous sclerosis
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TSC2 Happloinsufficiency Leads to a Mutator Phenotype
2007Abstract : Tuberous Sclerosis Complex (TSC) patients develop tumors of the brain, kidney, skin and heart upon loss of either the TSC1 or TSC2 gene, and we are interested in elucidating early molecular events that contribute to loss of TSC2 and in understanding how TSC2 heterozygosity might contribute to this process.
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