Results 131 to 140 of about 22,102 (233)

Biologics to Treat Atopic Dermatitis: Effectiveness, Safety, and Future Directions

Allergy, Volume 81, Issue 2, Page 326-344, February 2026.
ABSTRACT Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide. The clinical presentation of AD is heterogeneous and is characterized by a relapsing and remitting course. Most patients suffer from mild AD while approximately 5% to 20% experience severe disease activity, which often requires systemic treatment ...
Marjolein S. de Bruin‐Weller, Celeste M. Boesjes, Roselie A. Achten, Lisa A. Beck, Alan D. Irvine, Christian Vestergaard, Marlies de Graaf, Femke van Wijk, Daphne S. Bakker, Stephan Weidinger   +9 more
wiley   +1 more source

TSLP-Basophil axis

Folia Pharmacologica Japonica, 2014
Takahiro, Hatayama, Noriyasu, Hirasawa
openaire   +3 more sources

Oesophageal Epithelial Cell‐Intrinsic MHCII Regulates Food Antigen‐Dependent Eosinophilic Esophagitis in an IFNγ‐Dependent Manner

Clinical &Experimental Allergy, Volume 56, Issue 2, Page 124-136, February 2026.
We found that oesophageal epithelial cells upregulate MHCII expression during active EoE in humans and a mouse model. MHCII expression by EECs was governed by IFNγ‐inducible transcriptional elements. EEC‐intrinsic MHCII promoted regulatory T cell accumulation and attenuated eosinophilic oesophageal inflammation.
Eric M. Rodríguez‐López, Rachel L. Clement, Megha Lal, Yusen Zhou, Stephen D. Carro, Charles‐Antoine Assenmacher, Ravi Gautam, Jarad Beers, Amanda B. Muir, Jonathan M. Spergel, Melanie A. Ruffner, Laurence C. Eisenlohr, David A. Hill   +12 more
wiley   +1 more source

MSC‐Derived Secretome and Exosomes in Dermatology: Mechanisms, Therapeutic Opportunities, and Scientific Challenges—A Narrative Review

International Journal of Dermatology, Volume 65, Issue 2, Page 257-272, February 2026.
ABSTRACT Mesenchymal stromal cells (MSCs) exert their effects primarily through paracrine signaling via soluble factors and extracellular vesicles (EVs), especially exosomes. These acellular components offer regenerative and immunomodulatory benefits with fewer safety and logistical constraints than cell‐based therapies.
Marcela da Costa Pereira Cestari, Reinaldo Falavigna Tovo, Daniela Franco Bueno   +2 more
wiley   +1 more source

Bidirectional Communication Between Astrocytes and Neurons via Extracellular Vesicles: A Multi‐Omics Approach

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Schematic diagram illustrating the communication between mouse hippocampal astrocytes and neurons through extracellular vesicles (EVs). The illustration highlights unique proteins secreted by each cell type within EVs, with vesicle size proportional to the concentration of secreted proteins.
Daria Hajka, Paulina Żebrowska‐Różańska, Katarzyna Romańczuk, Jacek R. Wiśniewski, Łukasz Łaczmański, Norbert Łodej, Krzysztof J. Pawlik, Dariusz Rakus, Agnieszka Gizak   +8 more
wiley   +1 more source

LINFOPOYETINA ESTROMAL TÍMICA: REGULACIÓN DE LA RESPUESTA INMUNE Y LA ENFERMEDAD ALÉRGICA

Universitas Scientiarum, 2007
Recientemente se ha descrito una citocina similar a interleucina (IL) 7: Thymic Stromal Lymphopoietin (TSLP). La molécula TSLP es secretada por células epiteliales y en humanos estimula principalmente células de linaje mieloide, a diferencia del ratón ...
A. Cuéllar
doaj  

Thymic Stromal Lymphopoietin (TSLP)

Current allergy and asthma reports
Purpose of the Review: Thymic stromal lymphopoietin (TSLP) is increasingly recognized for its pivotal role in the pathogenesis of various epithelial-driven chronic inflammatory diseases. This review navigates the existing evidence on TSLP, with a particular focus on asthma, before delving into the current understanding of its role in chronic ...
de Corso, Eugenio, Hellings, Peter W., Fokkens, Wytske J., Klimek, Ludger, Peters, Anju T., Scadding, Glenis K., Desrosiers, Martin, Lee, Stella E., Mullol, Joaquim   +8 more
openaire   +1 more source

Thymic Stromal Lymphopoietin Activates Mouse Dendritic Cells Through the JAK/SYK Pathway in Promoting Th17 Response in Psoriasis

Balkan Medical Journal
Background: Psoriasis is a chronic inflammatory skin disease that has no cure. While the specific cause of psoriasis is unknown, interactions between immune cells and inflammatory cytokines are believed to be important in its pathogenesis. Thymic stromal
Cuihao Song, Jie Sun, Zhenkai Zhao, Xu Zhang, Xiangyu Ding, Xiaoqiang Liang, Jia Bai, Liyuan Xing, Lingling Gong, Chengxin Li, Biwen Lin   +10 more
doaj   +1 more source

Prolyl hydroxylase inhibition protects against murine MC903-induced skin inflammation by downregulating TSLP

Frontiers in Immunology
Previously, we reported an anti-inflammatory effect of mTORC1 in a mouse model of type 2 skin inflammation. TSLP, one of the epithelial cell-derived cytokines, was upregulated by Raptor deficiency or rapamycin treatment, which was inhibited by ...
Anupriya Gupta, Mi Hye Song, Dong Hyuk Youn, Dohyeon Ku, Varun Sasidharan Nair, Kwonik Oh, Kwonik Oh   +6 more
doaj   +1 more source

TSLP in bacterial skin infection [PDF]

Nature Immunology, 2016
openaire   +2 more sources