Results 51 to 60 of about 22,323 (211)

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. [PDF]

, 2011
Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including ...
Abel, Rebekah A, Adkinson, N Franklin, Ampleford, Elizabeth J, Avila, Lydiana, Avila, Pedro C, Barnes, Kathleen C, Baurley, James W, Beaty, Terri H, Bleecker, Eugene R, Burchard, Esteban G, Busse, William W, Calhoun, William J, Capurso, Daniel, Castro, Mario, Celedón, Juan C, Chapela, Rocio, Childhood Asthma Management Program (CAMP), Childhood Asthma Research and Education (CARE) Network, Children's Health Study (CHS) and HARBORS study, Chiu, Grace Y, Chung, Kian Fan, Conti, David V, Deichmann, Klaus A, del Rio-Navarro, Blanca, Diette, Gregory B, Dunston, Georgia M, Eng, Celeste, Ezurum, Serpil C, Faruque, Mezbah U, Ford, Jean G, Galanter, Joshua, Gauderman, W James, Genetic Research on Asthma in African Diaspora (GRAAD) Study, Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Asthma, Genes & Environments (SAGE), Gern, James E, Gignoux, Christopher R, Gilliland, Frank D, Graves, Penelope E, Hancock, Dana B, Hansel, Nadia N, Heinzmann, Andrea, Hernandez, Ryan D, Himes, Blanca E, Hu, Donglei, Huntsman, Scott, Israel, Elliott, Lemanske, Robert F, Levin, Albert M, Li, Xia, Li, Xingnan, Liang, Liming, London, Stephanie J, Mantese, Vito J, Martinez, Fernando D, Mathias, Rasika A, Mexico City Childhood Asthma Study (MCAAS), Meyers, Deborah A, Myers, Rachel A, Nicolae, Dan L, Ober, Carole, Raby, Benjamin A, Rafaels, Nicholas, Rodriguez-Cintron, William, Rodriquez-Santana, Jose R, Romieu, Isabelle, Ross, Kevin D, Roth, Lindsey A, Ruczinski, Ingo, Salam, Muhammad T, Shi, Min, Sienra-Monge, Juan J, Soto-Quiros, Manuel, Stern, Debra A, Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE), Togias, Alkis, Torgerson, Dara G, Van Den Berg, David J, Vora, Hita, Watson, Harold R, Weiss, Scott T, Wenzel, Sally E, Williams, L Keoki   +81 more
core   +2 more sources

Synthetic small interfering RNAs selectively suppress the expression of proinflammatory cytokine genes (IL-25 and TSLP) in experiments in vitro

Медицинская иммунология
Allergic rhinitis (AR) is an inflammatory disease of the upper respiratory tract (nasal mucosa). AR affects up to 40% of the world’s population; in the Russian Federation, the incidence is 18% to 30%, depending on the region.
M. M. Kaganova, I. P. Shilovskiy, E. D. Timotievich, K. V. Yumashev, D. A. Gurskii, K. V. Vinogradova, M. V. Popova, M. R. Khaitov   +7 more
doaj   +1 more source

TSLP bronchoalveolar lavage levels at baseline are linked to clinical disease severity and reduced lung function in children with asthma

Frontiers in Pediatrics, 2022
RationaleThymic stromal lymphopoietin (TSLP) is increasingly recognized as a key molecule in asthma pathogenesis and as a promising therapeutic target in adults.
Elizabeth Chorvinsky, Gustavo Nino, Kyle Salka, Susana Gaviria, Maria J. Gutierrez, Dinesh K. Pillai   +5 more
doaj   +1 more source

Cytokine and Lipid Mediator Regulation of Group 2 Innate Lymphoid Cells (ILC2s) in Human Allergic Airway Disease. [PDF]

, 2017
The recent discovery of group 2 innate lymphoid cells (ILC2s) has caused a paradigm shift in the understanding of allergic airway disease pathogenesis.
Cavagnero, Kellen, Doherty, Taylor A
core   +2 more sources

Thymic stromal lymphopoietin (TSLP) secretion from human nasal epithelium is a function of TSLP genotype [PDF]

Mucosal Immunology, 2015
Recent candidate gene and genome-wide association studies have identified "protective" associations between the single-nucleotide polymorphism (SNP) rs1837253 in the TSLP gene and risk for allergy, asthma, and airway hyperresponsiveness. The absence of linkage disequilibrium of rs1837253 with other SNPs in the region suggests it is likely a causal ...
C C K, Hui, A, Yu, D, Heroux, L, Akhabir, A J, Sandford, H, Neighbour, J A, Denburg   +6 more
openaire   +2 more sources

Early and Sustained Improvements in Sense of Smell With Tezepelumab Treatment in Patients With Chronic Rhinosinusitis With Nasal Polyps (WAYPOINT)

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Loss of smell is a principal symptom of chronic rhinosinusitis with nasal polyps (CRSwNP), affecting health‐related quality of life and posing a safety hazard. Methods WAYPOINT (NCT04851964), a phase 3, multicenter trial in adults with uncontrolled CRSwNP, randomized patients 1:1 to receive tezepelumab 210 mg or placebo ...
Joaquim Mullol, Joseph K. Han, Tanya M. Laidlaw, Claire Hopkins, Anju T. Peters, Oliver Pfaar, Martin Desrosiers, Stella E. Lee, Andrew P. Lane, Claudia Chen, Yun Chon, Sandhia S. Ponnarambil, Andrew Foster, Andrew W. Lindsley, Christopher S. Ambrose   +14 more
wiley   +1 more source

Tumor-derived thymic stromal lymphopoietin enhances lung metastasis through an alveolar macrophage-dependent mechanism

OncoImmunology, 2018
It is well-recognized that macrophages, which arise from circulating precursors, enhance tumor progression in patients and animal models. However, less is known regarding the role of tissue-resident macrophages in metastasis. Moreover, the identification
Lauren Burkard-Mandel, Rachel O'Neill, Sean Colligan, Mukund Seshadri, Scott I. Abrams   +4 more
doaj   +1 more source

Dupilumab Beyond the Airway: Decreased Morbidity in a Real‐World Analysis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Post hoc analyses of clinical trials have characterized dupilumab's adverse effects, yet the real‐world impact in chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma is not well described. This study aims to characterize the risks of lymphoma, cardiovascular events, eosinophilia, joint pain, inflammatory arthritis, and ...
Emma J. Anisman, Spencer Short, Emma Tam, Benjamin F. Bitner, Abdulghafoor Alani, Marc Rosen, Mindy Rabinowitz, Damaris Pena Evertz, Elina Toskala, Gurston G. Nyquist   +9 more
wiley   +1 more source

A novel monoclonal antibody against human thymic stromal lymphopoietin for the treatment of TSLP-mediated diseases

Frontiers in Immunology
IntroductionThymic stromal lymphopoietin (TSLP) is a master regulator of allergic inflammation against pathogens at barrier surfaces of the lung, skin, and gut.
Lihua Shi, Mingcan Yu, Ying Jin, Peng Chen, Guangmao Mu, Susan H. Tam, Minseon Cho, Mark Tornetta, Chao Han, Man-Cheong Fung, Mark L. Chiu, Di Zhang   +11 more
doaj   +1 more source

Allergic Rhinitis Amplifies Asthma Risk in Patients With Chronic Rhinosinusitis: A Large‐Scale Retrospective Cohort Analysis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are two highly prevalent airway diseases in the United States. While the coexistence of CRS and asthma is well recognized, less is known about the development of new‐onset asthma in CRS, particularly in the context of comorbid AR. This study assessed the impact of CRS and AR on
Austin J. Lee, Mohamad R. Chaaban
wiley   +1 more source