Results 51 to 60 of about 22,102 (233)

TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes

Cell & Bioscience, 2022
Background Thymic stromal lymphopoietin (TSLP) is a Th2-like cytokine involved in asthma pathogenesis. Excessive reactive oxygen species (ROS) production can lead to airway inflammation, hyperresponsiveness and remodeling.
Yi-Ching Lin, Yu-Chih Lin, Mei-Lan Tsai, Wei-Ting Liao, Chih-Hsing Hung   +4 more
doaj   +1 more source

Chitin-Induced Airway Epithelial Cell Innate Immune Responses Are Inhibited by Carvacrol/Thymol. [PDF]

, 2016
Chitin is produced in large amounts by fungi, insects, and other organisms and has been implicated in the pathogenesis of asthma. Airway epithelial cells are in direct contact with environmental particles and serve as the first line of defense against ...
Erle, David J, Khosravi, Ali Reza
core   +3 more sources

TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand. [PDF]

, 2017
T follicular helper cells (Tfh) are important regulators of humoral responses. Human Tfh polarization pathways have been thus far associated with Th1 and Th17 polarization pathways. How human Tfh cells differentiate in Th2-skewed environments is unknown.
Alain Hovnanian, Alculumbre, Andrea Cavani, Andrea Chiricozzi, Ballesteros-Tato, Bernasconi, Bernhard Homey, Brandt, Briot, Bryant, Choi, Coline Trichot, Coquet, Crotty, Deenick, Elisabetta Volpe, Furio, Giacomin, Glatman Zaretsky, Gould, Grewe, Gringhuis, Hatzi, He, Hovnanian, Ito, Ito, Jacquemin, Kemeny, Kim, Kroenke, Kusam, Leyva-Castillo, Liang, Liu, Locci, Lonati, Lucia Pattarini, Ma, Ma, Marco Romanelli, Maximilien Grandclaudon, Melanie Durand, Morita, Nakazawa, Nies, Niu, O’Shea, Pène, Ramalingam, Schmitt, Schmitt, Schmitt, Shin, Sofia Bogiatzi, Soumelis, Stefania Madonna, Stephan Meller, Tangye, Toshiyuki Hori, Trinchieri, Ueno, Van Roey, Vassili Soumelis, Volpe, Volpe, Wang, Weinstein, Ying, Yusuf, Zela Keuylian, Ziegler   +71 more
core   +3 more sources

Synthetic small interfering RNAs selectively suppress the expression of proinflammatory cytokine genes (IL-25 and TSLP) in experiments in vitro

Медицинская иммунология
Allergic rhinitis (AR) is an inflammatory disease of the upper respiratory tract (nasal mucosa). AR affects up to 40% of the world’s population; in the Russian Federation, the incidence is 18% to 30%, depending on the region.
M. M. Kaganova, I. P. Shilovskiy, E. D. Timotievich, K. V. Yumashev, D. A. Gurskii, K. V. Vinogradova, M. V. Popova, M. R. Khaitov   +7 more
doaj   +1 more source

TSLP bronchoalveolar lavage levels at baseline are linked to clinical disease severity and reduced lung function in children with asthma

Frontiers in Pediatrics, 2022
RationaleThymic stromal lymphopoietin (TSLP) is increasingly recognized as a key molecule in asthma pathogenesis and as a promising therapeutic target in adults.
Elizabeth Chorvinsky, Gustavo Nino, Kyle Salka, Susana Gaviria, Maria J. Gutierrez, Dinesh K. Pillai   +5 more
doaj   +1 more source

Cytokine and Lipid Mediator Regulation of Group 2 Innate Lymphoid Cells (ILC2s) in Human Allergic Airway Disease. [PDF]

, 2017
The recent discovery of group 2 innate lymphoid cells (ILC2s) has caused a paradigm shift in the understanding of allergic airway disease pathogenesis.
Cavagnero, Kellen, Doherty, Taylor A
core   +2 more sources

Thymic stromal lymphopoietin (TSLP) secretion from human nasal epithelium is a function of TSLP genotype [PDF]

Mucosal Immunology, 2015
Recent candidate gene and genome-wide association studies have identified "protective" associations between the single-nucleotide polymorphism (SNP) rs1837253 in the TSLP gene and risk for allergy, asthma, and airway hyperresponsiveness. The absence of linkage disequilibrium of rs1837253 with other SNPs in the region suggests it is likely a causal ...
C C K, Hui, A, Yu, D, Heroux, L, Akhabir, A J, Sandford, H, Neighbour, J A, Denburg   +6 more
openaire   +2 more sources

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Tumor-derived thymic stromal lymphopoietin enhances lung metastasis through an alveolar macrophage-dependent mechanism

OncoImmunology, 2018
It is well-recognized that macrophages, which arise from circulating precursors, enhance tumor progression in patients and animal models. However, less is known regarding the role of tissue-resident macrophages in metastasis. Moreover, the identification
Lauren Burkard-Mandel, Rachel O'Neill, Sean Colligan, Mukund Seshadri, Scott I. Abrams   +4 more
doaj   +1 more source

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source