Results 71 to 80 of about 17,739 (188)

Preferential Secretion of Thymic Stromal Lymphopoietin (TSLP) by Terminally Differentiated Esophageal Epithelial Cells: Relevance to Eosinophilic Esophagitis (EoE).

PLoS ONE, 2016
Eosinophilic esophagitis (EoE) is a chronic Th2 and food antigen-mediated disease characterized by esophageal eosinophilic infiltration. Thymic stromal lymphopoetin (TSLP), an epithelial derived cytokine which bridges innate and Th2-type adaptive immune ...
Prasanna M Chandramouleeswaran, Dawen Shen, Anna J Lee, Alain Benitez, Kara Dods, Fiona Gambanga, Benjamin J Wilkins, Jamie Merves, Yuliana Noah, Sarit Toltzis, Jennifer H Yearley, Jonathan M Spergel, Hiroshi Nakagawa, Rene deWaal Malefyt, Amanda B Muir, Mei-Lun Wang   +15 more
doaj   +1 more source

Molecular Heterogeneity in Clinically Ambiguous Atopic Dermatitis–Psoriasis Overlap: Compartment‐Resolved Transcriptomic Profiling

Allergy, EarlyView.
Compartment‐resolved transcriptomic profiling of AD, PsO, and clinically ambiguous AD‐PsO overlap lesions reveals molecular heterogeneity, with overlap lesions showing relative alignment toward AD‐like or PsO‐like patterns. AD‐like alignment is associated with epidermal barrier and dermal neural/sensory pathways, whereas PsO‐like alignment is ...
Jongeun Lee, Yookyung Sophie Chun, Hyo Jeong Nam, Yun Jung Huh, Jaehwan Kim, James G. Krueger, Seung Sam Paik, Hyun Je Kim, Seon‐Pil Jin, Jeong Eun Kim   +9 more
wiley   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

European Guidelines on Eosinophilic Esophagitis: Evidence‐Based Statements and Recommendations for Diagnosis and Management in Children and Adults. Part 1: Diagnosis, Epidemiology and Natural History

Allergy, EarlyView.
The European evidence‐based guidelines on eosinophilic esophagitis (Part 1). This infographic summarizes the methodological framework and core clinical outputs of the updated consensus developed by multidisciplinary experts from EUREOS, EAACI, ESPGHAN, and ESP.
Alfredo J. Lucendo, Javier Molina‐Infante, Ángel Arias, Ulrike von Arnim, Henrik Bergquist, Luc Biedermann, Albert J. Bredenoord, Marie Carlson, Javier Chahuan, Jorge Amil Dias, Thomas Eiwegger, Sara Feo‐Ortega, Sandra L. Garcia‐Dionisio, Matteo Ghisa, Jesús González‐Cervera, Thomas Greuter, Danila Guagnozzi, Carolina Gutiérrez‐Junquera, Lucía Gutiérrez‐Ramírez, Cord Langner, Helen Larsson, Anne Lund Krarup, Salvatore Oliva, Alexandra Papadopoulou, Francesca Racca, Cecilio Santander, Edoardo Vincenzo Savarino, Christoph Schlag, Alain M. Schoepfer, Martin A. Storr, Antonio Tejera‐Muñoz, Noam Zevit, Stephen E. Attwood, Alex Straumann   +33 more
wiley   +1 more source

Environmental Changes and Their Effect on the Airway Microbiome: Implications for Airway Diseases

Allergy, EarlyView.
ABSTRACT Obstructive airway diseases, including asthma and chronic obstructive pulmonary disease (COPD), represent the two major chronic airway inflammatory diseases. In both conditions, the airways are exposed to a variety of microbial and environmental stimuli.
Georgios Rentzos, Evangelia Fouka, Nikolaos Lazarinis, Theo Gülen, Patricia Ramos‐Ramirez, Lauren Flynn, Stelios Loukides, Paraskevi Xepapadaki, Nikolaos G. Papadopoulos, Anders Lindén, Apostolos Bossios   +10 more
wiley   +1 more source

TSLP is associated with asthma

, 2021
Background Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general).
Mathias, Rasika A., Choi, Augustine M.K., Wilk, Jemma B., Ruczinski, Ingo, Bush, Andrew, Soto-Quirós, Manuel E., Lasky‐Su, Jessica A., Hunninghake, Gary, Klanderman, Barbara, Liang, Catherine, Celedón, Juan C., Gauderman, W. James, Raby, Benjamin, Weiss, Scott, Baurley, James W., Sylvia, Jody, Vora, Hita, O’Connor, George T., Himes, Blanca E., Sharma, Sunita, Israel, Elliot, Beaty, Terry H., Bossley, Cara J., Avila, Lydiana, Kim, Hong P., Rafaels, Nicholas, Barnes, Kathleen C., Gilliland, Frank   +27 more
core   +1 more source

TSLP expression and high serum TSLP level indicate a poor prognosis in gastric cancer patients [PDF]

, 2015
鳥取大学博士(医学)Joji Watanabe, Hiroaki Saito, Kozo Miyatani, Masahide Ikeguchi and Yoshihisa Umekita. TSLP expression and high serum TSLP level indicate a poor prognosis in gastric cancer patients. Yonago acta medica.
渡邉, 淨司, 4168, ワタナベ, ジョウジ, Watanabe, Joji, 100000915   +4 more
core   +1 more source

Targeting thymic stromal lymphopoietin in nasal type 2 inflammation

Eye & ENT Research
Epithelial cell‐derived thymic stromal lymphopoietin (TSLP) plays a crucial role in mediating type 2 immune responses, which is one of the key underlying pathophysiological mechanisms of allergic rhinitis (AR) and most presentations of chronic ...
Xintong Li, Jingjing Guo, Jing Song, Ming Wang   +3 more
doaj   +1 more source

Thymic Stromal Lymphopoietin Signaling Pathway Inhibition Attenuates Airway Inflammation and Remodeling in Rats with Asthma

Cellular Physiology and Biochemistry, 2018
Background/Aims: Thymic stromal lymphopoietin (TSLP) is a cytokine that plays diverse roles in the regulation of immune responses. However, a detailed understanding of the TSLP signaling pathway in asthma remains elusive.
Zhe  Cheng, Xi Wang, Ling-Ling Dai, Liu-Qun Jia, Xiao-Gang Jing, Ying Liu, Huan Wang, Peng-Fei Li, Lin An, Meng Liu   +9 more
doaj   +1 more source

Inflammatory Mediators Associated With Corticosteroid Responsiveness During Asthma Attacks

Clinical &Experimental Allergy, EarlyView.
ABSTRACT Higher baseline sputum/serum eotaxin‐3 and serum IL‐5 levels were associated with greater FEV1 improvement following OCS during asthma attacks. Corticosteroid‐induced inflammatory modulation differed across T2 phenotypes during asthma attacks.
Carlos Celis‐Preciado, Elsa Ben Hamou Kuijpers, Mohamed‐Ilias Kourid, Simon Leclerc, Martine Duval, Dominic O. Cliche, Félix‐Antoine Vézina, Pierre Larivée, Samuel Lemaire‐Paquette, Philippe Lachapelle, Martin Klein, Simon Couillard   +11 more
wiley   +1 more source