Results 91 to 100 of about 17,739 (188)

Microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases

Periodontology 2000, EarlyView.
Abstract Objectives To critically evaluate the current evidence on microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases, with emphasis on their biological relevance, potential clinical utility, and current translational limitations.
Su Sheng Quach, Ausra Ramanauskaite, Sašo Ivanovski, Pingping Han, Frank Schwarz, Emilio A. Cafferata   +5 more
wiley   +1 more source

IL-3 and TNFα increase Thymic Stromal Lymphopoietin Receptor (TSLPR) expression on eosinophils and enhance TSLP-stimulated degranulation [PDF]

, 2012
Background Thymic stromal lymphopoietin (TSLP) and eosinophils are prominent components of allergic inflammation. Therefore, we sought to determine whether TSLP could activate eosinophils, focusing on measuring the regulation of TSLPR expression on ...
Cook Ellen B, Elizabeth A Schwantes, Kristen E Fox, Stahl James L, Fox Kristen E, Ellen B Cook, Sameer K Mathur, Schwantes Elizabeth A, James L Stahl, Mathur Sameer K   +9 more
core   +1 more source

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

The Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck, Carlos Matellan, Cristina Bauset, Bella Raphael, Mary Nwaezeigwe, Emer Flynn, Kevin Okamoto, Desmond Winter, Colm Collins, Katie Doogan, Seán T. Martin, Glen Doherty, Seema S. Aceves, Mario C. Manresa   +13 more
wiley   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Regulation of IL‐13 Signaling by Retinoic Acid in Airway Epithelial Cells

The FASEB Journal, Volume 40, Issue 21, 15 November 2026.
Our proteomics and subsequent biochemical analyses reveal the effects of retinoic acid receptor (RAR) agonists, ATRA (pan‐RAR agonist), or CD1530 (RARγ agonist) in counteracting molecular changes induced by IL‐13 relevant to airway inflammation and remodeling, such as proteins involved in epithelial‐to‐mesenchymal transition (EMT) and extracellular ...
Vanshika Patel, Jianshi Yu, Mehari Weldemariam, Paul Shapiro, Deepak A. Deshpande, Maureen A. Kane   +5 more
wiley   +1 more source

TSLP and Immune Homeostasis

, 2012
In an immune system, dendritic cells (DCs) are professional antigen-presenting cells (APCs) as well as powerful sensors of danger signals. When DCs receive signals from infection and tissue stress, they immediately activate and instruct the initiation of
Norihiko Watanabe, Shino Hanabuchi, Yong-Jun Liu   +2 more
core   +1 more source

TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand [PDF]

, 2017
T follicular helper cells (Tfh) are important regulators of humoral responses. Human Tfh polarization pathways have been thus far associated with Th1 and Th17 polarization pathways. How human Tfh cells differentiate in Th2-skewed environments is unknown.
Maximilien Grandclaudon, Homey, B., Sofia Bogiatzi, Volpe, Elisabetta, Marco Romanelli, Romanelli, M., Lucia Pattarini, Toshiyuki Hori, Chiricozzi, A., Hovnanian, A., Hovnanian, Alain, Keuylian, Z., Bogiatzi, Sofia, Durand, Melanie, Vassili Soumelis, Meller, Stephan, Trichot, C., Cavani, A., Trichot, Coline, ROMANELLI, MARCO, Durand, M., Hori, T., Stephan Meller, Bogiatzi, S., Pattarini, L., Volpe, E., Stefania Madonna, Homey, Bernhard, Soumelis, Vassili, Grandclaudon, Maximilien, Elisabetta Volpe, Grandclaudon, M., Coline Trichot, Pattarini, Lucia, Hori, Toshiyuki, CHIRICOZZI, ANDREA, Andrea Chiricozzi, Madonna, Stefania, Cavani, Andrea, Andrea Cavani, Soumelis, V., Melanie Durand, Keuylian, Zela, Madonna, S., Alain Hovnanian, Bernhard Homey, Zela Keuylian, Meller, S., Pattarini L, Durand M, Meller S, Homey B, Grandclaudon M, Hovnanian A, Madonna S, Chiricozzi A, Keuylian Z, Cavani A, Romanelli M, Bogiatzi S, Volpe E, Soumelis V, Hori T, Trichot C   +63 more
core   +1 more source

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

International Forum of Allergy &Rhinology, Volume 16, Issue 11, Page 1309-1317, November 2026.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu, Houyong Li, Xicai Sun, Quan Liu, Yu Xu, Jiangang Fan, Andrew Foster, Claudia Chen, Yun Chon, Dehui Wang   +9 more
wiley   +1 more source

Directional secretory response of double stranded RNA-induced thymic stromal lymphopoetin (TSLP) and CCL11/eotaxin-1 in human asthmatic airways. [PDF]

, 2014
BACKGROUND:Thymic stromal lymphoproetin (TSLP) is a cytokine secreted by the airway epithelium in response to respiratory viruses and it is known to promote allergic Th2 responses in asthma.
Dinesh K Pillai, Eng, Stephen, Perez, Geovanny F., Geovanny F Perez, Mary C. Rose, Anamaris M. Colberg-Poley, Wang, Justin, Anamaris M Colberg-Poley, Colberg-Poley, Anamaris M., Gustavo Nino, Abeesi, Aleeza, Nino, Gustavo, Pancham, Krishna, Huseni, Shehlanoor, Dinesh K. Pillai, Stephen Eng, Rose, Mary C., Mubeen, Humaira, Krishna Pancham, Geovanny F. Perez, Justin Wang, Shehlanoor Huseni, Humaira Mubeen, Aleeza Abbasi, Mary C Rose, Huseni Shehlanoor, Wang Justin, Perez Geovanny F., Abbasi Aleeza, Colberg-Poley Anamaris M., Nino Gustavo, Pancham Krishna, Mubeen Humaira, Rose Mary C., Pillai Dinesh K., Eng Stephen   +35 more
core   +2 more sources

House dust mites stimulate thymic stromal lymphopoietin production in human bronchial epithelial cells and promote airway remodeling through activation of PAR2 and ERK signaling pathway

Scientific Reports
House dust mites (HDM) are common aeroallergens linked to airway inflammation and remodeling in asthma. Protease-activated receptor 2 (PAR2) and thymic stromal lymphopoietin (TSLP) may mediate these immune responses.
Yi-An Hsieh, Yi-Han Hsiao, Hsin-Kuo Ko, Yi-Luen Shen, Chien-Wen Huang, Diahn-Warng Perng, Kang-Cheng Su   +6 more
doaj   +1 more source