Results 101 to 110 of about 17,739 (188)

Inflammatory Signatures Beyond Th1/Th2 Endotypes Provide Insights Into Postoperative Recurrence in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, Volume 16, Issue 11, Page 1269-1279, November 2026.
ABSTRACT Background Chronic rhinosinusitis (CRS) represents a spectrum of inflammatory endotypes, driven by distinct T helper (Th) immune responses. The high rate of recurrent disease despite appropriate medical and surgical interventions highlights the need for improved characterization beyond the traditional type 2 and non‐type 2 phenotypes to better
Liyona Kampel, Narin N. Carmel, Shaun Edalati, Hen Chaushu, Forsan Jahshan, Yaniv Hadi, Timur Pestrikov, Leonor Leider Trejo, Nidal Muhanna, Avraham Abergel   +9 more
wiley   +1 more source

A Bispecific Antibody Blocking Both TSLP and IL-4Rα for the Treatment of Allergic Inflammatory Diseases

Cells
Thymic stromal lymphopoietin (TSLP) works synergistically with Th2 cytokines to regulate infection, inflammation, and metabolic homeostasis. However, their aberrant activities lead to the onset and sustaining of many types of allergic inflammatory ...
Mingcan Yu, Peng Chen, Ying Jin, Sheng Huang, Hao Jiang, Fulai Zhou, Mark L. Chiu, Di Zhang   +7 more
doaj   +1 more source

Evaluating the Impact of Prior Sponge and Lavage Sampling on Gene Expression of Nasal CMA1 and TSLP Collected With Brush

Clinical &Experimental Allergy, EarlyView.
Abigail Davis, Sophie Spicer, Lubnaa Hossenbaccus, Anne K. Ellis   +3 more
wiley   +1 more source

Efficacy and Predictors of Response to Biologic Therapy and Endoscopic Sinus Surgery in Patients With Nasal Polyps: A Systematic Review

International Forum of Allergy &Rhinology, Volume 16, Issue 11, Page 1342-1351, November 2026.
ABSTRACT Background Biologics and endoscopic sinus surgery (ESS) treat refractory chronic rhinosinusitis with nasal polyposis (CRSwNP), but direct comparisons are lacking. We synthesized efficacy and subgroup data across randomized controlled trials (RCTs) of biologics and ESS.
Arun Chakravorty, Matthew E. Lin, Rory Lubner, Jess C. Mace, Jeffrey Suh, Jivianne Lee, Marilene Wang, Sarah Wise, Naweed Chowdhury, Zachary M. Soler, Justin Turner, Timothy L. Smith, Myung Sim, Daniel M. Beswick   +13 more
wiley   +1 more source

Benralizumab Inhibits Upper Airway Expression of Thymic Stromal Lymphopoietin in Severe Asthma

Clinical &Experimental Allergy, EarlyView.
Hazel Marriott, Marc Duchesne, Jalal Moolji, Adil Adatia, Subhabrata Moitra, Paige Lacy   +5 more
wiley   +1 more source

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3819-3830, November 2026.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source

Targeting viral induced TSLP - an airway treatment opportunity

, 2014
Respiratory viral infections cause exacerbations of asthma and COPD that cannot be effectively treated today. Thymic Stromal Lymphopoietin (TSLP) is an upstream epithelial cytokine linking the innate and adaptive immune system.
Brandelius, Angelica,, Lund University.
core   +1 more source

Time‐of‐Day Variation in Airway Hyperresponsiveness in Asthma: Potential Circadian Mechanisms and Translational Implications

Clinical and Translational Allergy, Volume 16, Issue 11, November 2026.
Graphical abstract Biological time, time‐dependent airway hyperresponsiveness, and clinical translation. The external day–night cycle entrains the central clock in the suprachiasmatic nucleus and peripheral pulmonary clocks, whereas sleep and activity, posture, environmental exposures, and medication timing modify the airway state observed at a given ...
Chang Zhou, Xinyue Hu, Lijuan Zeng, Yi Tang, Chuxian Yi, Guomin Zhang, Sujuan Peng   +6 more
wiley   +1 more source

Blockade of thymic stromal lymphopoietin (TSLP) receptor inhibits TSLP-driven proliferation and signalling in lymphoblasts from a subset of B-precursor ALL patients

, 2016
PURPOSE: The cytokine thymic stromal lymphopoietin (TSLP) and its receptor TSLPR are involved in intercellular communication in the course of allergic inflammation and have recently been implicated in the development of various malignancies including
Ranjan, Nilabh, Tina Vetter, Oliver G. Ottmann, Nilabh Ranjan, Ottmann, Oliver, Susanne Badura, Friedrich, Karlheinz, Vetter, Tina, Andreas Wohlmann, Borowski, Andreas, Andreas Borowski, Karlheinz Friedrich, Wohlmann, Andreas, Kuepper, Michael, Michael Kuepper, Badura, Susanne   +15 more
core   +1 more source

From Biological Mechanisms to Causal Inference: Quantitative Systems Pharmacology and Causal Frameworks in Drug Development

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1255-1265, November 2026.
Digital patients and in silico clinical trials offer new opportunities to advance pharmacological research, clinical development, and regulatory decision‐making by enabling the simulation of treatment effects prior to testing in patients. Among the most promising of these opportunities is the combined use of quantitative systems pharmacology (QSP) and ...
Thomas Klabunde, Ramon Hernandez, Piet H. van der Graaf, Tommaso Andreani   +3 more
wiley   +1 more source