Results 81 to 90 of about 16,704 (236)
TSLP neutralization inhibits airway structural alterations.
, 2013 (A) The depth of peribronchial collagen deposition was significantly reduced in anti-TSLP-treated mice, compared with HDM-exposed and IgG isotype-treated controls.
Tian-Tuo Zhang (290781) +6 more
core +1 more source
Serum‐Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity‐Linked Signatures
Allergy, EarlyView.This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial enriched severity footprint linked to LDH‐associated tissue injury and Th2/Th22 inflammation.
Jag S. Lally +6 more
wiley +1 more source
The Biology of Thymic Stromal Lymphopoietin (TSLP) [PDF]
, 2013 Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic and nonhematopoietic cell lineages, including dendritic cells, basophils, eosinophils, mast cells, CD4⁺, CD8⁺ and natural killer T cells, B cells and epithelial cells. While TSLP's role in
Steven F, Ziegler +5 more
openaire +2 more sources
Food antigens induce esophageal epithelial TSLP expression.
, 2016 Quantification of TSLP mRNA expression following food antigen stimulation in undifferentiated (A) and differentiated (B) EPC2-hTERT cells. C) TSLP secretion (pg/mL) was quantified in undifferentiated and differentiated EPC2-hTERT cells. TSLP secretion in
Fiona Gambanga (3176286) +15 more
core +1 more source
Allergy, EarlyView.Nasal epithelial transcriptomics identified three cytokine‐associated epithelial immune programs linked to childhood asthma phenotypes. Age‐associated epithelial polarization shifted from IFN/type‐17‐associated toward type‐2‐associated programs after 3 years of age.
Constanze A. Jakwerth +71 more
wiley +1 more source
The External Exposome and Food Allergy: How Environmental Exposures Shape Disease Risk
Allergy, EarlyView.ABSTRACT IgE‐mediated food allergy is a global health issue with rising prevalence that cannot be explained by genetic change alone, strongly suggesting that environmental exposures are a key driver. The external exposome encompasses several exposures that influence the developing immune system and modify food allergy risk.
Johanna M. Smeekens +5 more
wiley +1 more source
Specificity evaluation of the TSLP and USLP.
, 2014 (A) PCR bands of miR-150 and miR-155 were detected by both TSLP and USLP methods. The PCR products were run on 3% agarose gel in 1X TBE stained with ethidium bromide. (B) Melting curve of the TSLP and USLP methods for detecting synthetic miR-155.
Si-lu Wang (680189) +8 more
core +1 more source
Allergy, EarlyView.ABSTRACT Among bacteria that are associated with the development and/or exacerbation of allergic/atopic diseases, several have been described to produce IgE‐binding components. However, only one bacterial protein, Bac s 1, is currently listed in the official database of the World Health Organization/International Union of Immunological Societies (WHO ...
Uta Jappe +24 more
wiley +1 more source
Targeting thymic stromal lymphopoietin in nasal type 2 inflammation
Eye & ENT ResearchEpithelial cell‐derived thymic stromal lymphopoietin (TSLP) plays a crucial role in mediating type 2 immune responses, which is one of the key underlying pathophysiological mechanisms of allergic rhinitis (AR) and most presentations of chronic ...
Xintong Li +3 more
doaj +1 more source
Thymic stromal lymphopoietin in leukemia: A double-edged sword?
Leukemia Research ReportsThymic stromal lymphopoietin (TSLP) is a cytokine expressed by various cell types. It is involved in the development of allergies, autoimmune diseases, and cancers.
Xing Zou +6 more
doaj +1 more source