Results 81 to 90 of about 17,739 (188)
Thymic stromal lymphopoietin in leukemia: A double-edged sword?
Leukemia Research ReportsThymic stromal lymphopoietin (TSLP) is a cytokine expressed by various cell types. It is involved in the development of allergies, autoimmune diseases, and cancers.
Xing Zou +6 more
doaj +1 more source
Cells, 2019 Mast cells (MCs) play critical roles in allergic and inflammatory reactions and contribute to multiple pathologies in the skin, in which they show increased numbers, which frequently correlates with severity. It remains ill-defined how MC accumulation is
Tarek Hazzan +3 more
doaj +1 more source
Structure and interaction of the TSLP-T6 complex.
(A) ELISA experiments determining the binding epitopes of AMG157 and T6 on TSLP. (B) Complex structure of TSLP (shown in aquamarine) and T6 (shown in light blue). The binding interface is depicted in wheat color. (C) Ligplot+ analysis of the interactions
Lei Xu (78676) +7 more
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TSLP-Stimulated T Helper 2 Cells Induce Senescence in Advanced Breast Cancer
, 2023 Thymic Stromal Lymphopoietin, or TSLP, has a prominent role in inducing type II immune response, which is commonly associated with a tumor promotion. However, our studies have shown that TSLP induction is capable of driving T helper (Th) 2 polarization ...
Pham, Quan Minh
core +2 more sources
Development of a novel humanized anti-TSLP monoclonal antibody HZ-1127 with anti-allergic diseases and cancer potential. [PDF]
Thymic stromal lymphopoietin (TSLP) is a member of the IL-2 cytokine family and has been widely recognized as a master regulator of type 2 inflammatory responses at barrier surfaces.
Han, Jianzhong +9 more
core +1 more source
International Journal of Cosmetic Science, EarlyView.In a cytokine‐challenged human epidermal model, trans‐resveratrol reduces inflammation (IL‐1α) and oxidative stress markers (CYP1A1, CYP1B1), while modulating the expression of barrier‐related genes (LOR, OCLN) and differentiation‐associated CASP14. This supports its role as a multifunctional active for sensitive and compromised skin.
Irini M. Dijkhoff +6 more
wiley +1 more source
Role of TSLP in Dendritic Cell Programming during Allergic Responses
, 2016 Allergic diseases such as atopic dermatitis (AD), asthma and allergic rhinitis are among the most common chronic illnesses around the world. Although they cause significant discomfort to those affected, effective treatments are currently not available ...
Ochiai, Sotaro
core
Immunology, EarlyView.This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann +7 more
wiley +1 more source
TSLP Expression: Cellular Sources, Triggers, and Regulatory Mechanisms
Allergology International, 2012 Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine initially identified in the culture supernatant of a thymic stromal cell line. Highly expressed in the epidermis in skin lesions of atopic dermatitis patients, TSLP was subsequently found to be
Toshiro Takai
doaj +1 more source
Journal of Asthma and AllergyAndrew W Lindsley,1 Njira Lugogo,2 Kaitlin AG Reeh,3 Joseph Spahn,3 Jane R Parnes1 1Amgen Inc., Thousand Oaks, CA, USA; 2Michigan Medicine Asthma Program, University of Michigan, Ann Arbor, MI, USA; 3AstraZeneca, Gaithersburg, MD, USACorrespondence ...
Lindsley AW +4 more
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